Search Results - "Hewawasam, Rukshika"
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Chemical Modification of Human Decellularized Extracellular Matrix for Incorporation into Phototunable Hybrid-Hydrogel Models of Tissue Fibrosis
Published in ACS applied materials & interfaces (29-03-2023)“…Tissue fibrosis remains a serious health condition with high morbidity and mortality rates. There is a critical need to engineer model systems that better…”
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Urea and Thiourea H‑Bond Donating Catalysts for Ring-Opening Polymerization: Mechanistic Insights via (Non)linear Free Energy Relationships
Published in Macromolecules (24-04-2018)“…Hammett-style free energy studies of (thio)urea/MTBD mediated ring-opening polymerization (ROP) of δ-valerolactone reveal the complicated interplay of…”
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Engineering Dynamic 3D Models of Lung
Published in Advances in experimental medicine and biology (2023)“…The lung parenchyma-consisting of gas-filled alveoli, vasculature, and connective tissue-is the site for gas exchange in the lung and plays a critical role in…”
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Bisurea and Bisthiourea H‑Bonding Organocatalysts for Ring-Opening Polymerization: Cues for the Catalyst Design
Published in Macromolecules (10-12-2019)“…A series of conformationally flexible bis(thio)urea H-bond donors plus base cocatalyst were applied to the ring-opening polymerization (ROP) of lactones. The…”
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Alveolar epithelial cells and microenvironmental stiffness synergistically drive fibroblast activation in three-dimensional hydrogel lung models
Published in Biomaterials science (06-12-2022)“…Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease that progressively and irreversibly alters the lung parenchyma, eventually leading to…”
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Engineering Hybrid-Hydrogels Comprised of Healthy or Diseased Decellularized Extracellular Matrix to Study Pulmonary Fibrosis
Published in Cellular and molecular bioengineering (01-10-2022)“…Idiopathic pulmonary fibrosis is a chronic disease characterized by progressive lung scarring that inhibits gas exchange. Evidence suggests fibroblast-matrix…”
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Development of Organocatalysts for Ring-Opening Polymerization (ROP) of Lactones
Published 01-01-2020“…Organocatalysis for Ring-Opening Polymerization (ROP) has come a long way in recent developments to afford precisely tailored and highly adorned biodegradable…”
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Dissertation