Search Results - "Heward, Christopher B"

A survey of genetic human cortical gene expression by Myers, Amanda J, Gibbs, J Raphael, Webster, Jennifer A, Rohrer, Kristen, Zhao, Alice, Marlowe, Lauren, Kaleem, Mona, Leung, Doris, Bryden, Leslie, Nath, Priti, Zismann, Victoria L, Joshipura, Keta, Huentelman, Matthew J, Hu-Lince, Diane, Coon, Keith D, Craig, David W, Pearson, John V, Holmans, Peter, Heward, Christopher B, Reiman, Eric M, Stephan, Dietrich, Hardy, John

“…It is widely assumed that genetic differences in gene expression underpin much of the difference among individuals and many of the quantitative traits of…”
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Disparate LDL Phenotypic Classification among 4 Different Methods Assessing LDL Particle Characteristics by Ensign, Wayne, Hill, Nicole, Heward, Christopher B

“…Our study seeks to clarify the extent of differences in analytical results, from a clinical perspective, among 4 leading technologies currently used in…”
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A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease by COON, Keith D, MYERS, Amanda J, HALPERIN, Rebecca F, MARLOWE, Lauren, KALEEM, Mona, WALKER, Douglas G, RAVID, Rivka, HEWARD, Christopher B, ROGERS, Joseph, PAPASSOTIROPOULOS, Andreas, REIMAN, Eric M, HARDY, John, CRAIG, David W, STEPHAN, Dietrich A, WEBSTER, Jennifer A, PEARSON, John V, HU LINCE, Diane, ZISMANN, Victoria L, BEACH, Thomas G, LEUNG, Doris, BRYDEN, Leslie

“…While the apolipoprotein E (APOE) epsilon allele is a well-established risk factor for late-onset Alzheimer's disease (AD), initial genome scans using…”
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Genetic Control of Human Brain Transcript Expression in Alzheimer Disease by Webster, Jennifer A., Gibbs, J. Raphael, Clarke, Jennifer, Ray, Monika, Zhang, Weixiong, Holmans, Peter, Rohrer, Kristen, Zhao, Alice, Marlowe, Lauren, Kaleem, Mona, McCorquodale, Donald S., Cuello, Cindy, Leung, Doris, Bryden, Leslie, Nath, Priti, Zismann, Victoria L., Joshipura, Keta, Huentelman, Matthew J., Hu-Lince, Diane, Coon, Keith D., Craig, David W., Pearson, John V., Heward, Christopher B., Reiman, Eric M., Stephan, Dietrich, Hardy, John, Myers, Amanda J.

“…We recently surveyed the relationship between the human brain transcriptome and genome in a series of neuropathologically normal postmortem samples. We have…”
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CR1 is associated with amyloid plaque burden and age-related cognitive decline by Chibnik, Lori B., Shulman, Joshua M., Leurgans, Sue E., Schneider, Julie A., Wilson, Robert S., Tran, Dong, Aubin, Cristin, Buchman, Aron S., Heward, Christopher B., Myers, Amanda J., Hardy, John A., Huentelman, Matthew J., Corneveaux, Jason J., Reiman, Eric M., Evans, Denis A., Bennett, David A., De Jager, Philip L.

“…Objective Recently, genome‐wide association studies have identified 3 new susceptibility loci for Alzheimer's disease (AD), CLU, CR1, and PICALM. We leveraged…”
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Tart cherry juice decreases oxidative stress in healthy older men and women by Traustadóttir, Tinna, Davies, Sean S, Stock, Anthoney A, Su, Yali, Heward, Christopher B, Roberts, 2nd, L Jackson, Harman, S Mitchell

“…Compared with young adults, older adults have significantly impaired capacities to resist oxidative damage when faced with acute stress such as…”
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Discrimination of Breast Cancer by Anti-Malignin Antibody Serum Test in Women Undergoing Biopsy by HARMAN, S. Mitchell, GUCCIARDO, Frank, HEWARD, Christopher B, GRANSTROM, Per, BARCLAY-WHITE, Belinda, ROGERS, Lowell W, IBARRA, Julio A

“…Purpose: The anti-malignin antibody serum (AMAS) test (Oncolab, Boston, MA) has been reported as 97% sensitive and 95% specific for malignancies. To…”
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The Women's Health Initiative could not have detected cardioprotective effects of starting hormone therapy during the menopausal transition by Naftolin, Frederick, Taylor, Hugh S, Karas, Richard, Brinton, Eliot, Newman, Isadore, Clarkson, Thomas B, Mendelsohn, Michael, Lobo, Rogerio A, Judelson, Debra R, Nachtigall, Lila E, Heward, Christopher B, Hecht, Harvey, Jaff, Michael R, Harman, S Mitchell

“…The Women's Health Initiative (WHI) randomized controlled trial failed to show cardioprotection by estrogen plus progestin treatment of postmenopausal women…”
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Quantification of 8-iso-prostaglandin-F2α and 2,3-dinor-8-iso-prostaglandin-F2α in human urine using liquid chromatography-tandem mass spectrometry by Liang, Yuanling, Wei, Ping, Duke, Russell W, Reaven, Peter D, Harman, S.Mitchell, Cutler, Richard G, Heward, Christopher B

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Urinary excretion of three nucleic acid oxidation adducts and isoprostane F2α measured by liquid chromatography-mass spectrometry in smokers, ex-smokers, and nonsmokers by Harman, S.Mitchell, Liang, Lynn, Tsitouras, Panayiotis D, Gucciardo, Frank, Heward, Christopher B, Reaven, Peter D, Ping, Wei, Ahmed, Alaa, Cutler, Richard G

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Time to Talk SENS: Critiquing the Immutability of Human Aging by DE GREY, AUBREY D. N. J., AMES, BRUCE N., ANDERSEN, JULIE K., BARTKE, ANDRZEJ, CAMPISI, JUDITH, HEWARD, CHRISTOPHER B., McCARTER, ROGER J. M., STOCK, GREGORY

“…Aging is a three‐stage process: metabolism, damage, and pathology. The biochemical processes that sustain life generate toxins as an intrinsic side effect…”
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The Effects of Aging on Hormone and Reproductive Cycles in Female Chimpanzees (Pan troglodytes) by Videan, Elaine N, Fritz, Jo, Heward, Christopher B, Murphy, James

“…In contrast to those for human females, observational cycle data available for chimpanzees suggest that menstrual cycling, and thus reproductive potential,…”
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Comparison of Biomarkers of Oxidative Stress and Cardiovascular Disease in Humans and Chimpanzees (Pan troglodytes) by Videan, Elaine N, Heward, Christopher B, Chowdhury, Kajal, Plummer, John, Su, Yali, Cutler, Richard G

“…In the oxidative stress hypothesis of aging, the aging process is the result of cumulative damage by reactive oxygen species. Humans and chimpanzees are…”
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Negligible senescence: how will we know it when we see it? by Heward, Christopher B

“…The recent public claim that "SENS is a practical, foreseeable approach to curing aging" has stirred considerable controversy among bio-gerontologists. Testing…”
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Sorl1 as an Alzheimer's disease predisposition gene? by Webster, Jennifer A, Myers, Amanda J, Pearson, John V, Craig, David W, Hu-Lince, Diane, Coon, Keith D, Zismann, Victoria L, Beach, Thomas, Leung, Doris, Bryden, Leslie, Halperin, Rebecca F, Marlowe, Lauren, Kaleem, Mona, Huentelman, Matthew J, Joshipura, Keta, Walker, Douglas, Heward, Christopher B, Ravid, Rivka, Rogers, Joseph, Papassotiropoulos, Andreas, Hardy, John, Reiman, Eric M, Stephan, Dietrich A

“…Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressively disabling impairments in memory, cognition, and non-cognitive…”
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Is the WHI relevant to HRT started in the perimenopause? by Harman, S Mitchell, Brinton, Eliot A, Clarkson, Thomas, Heward, Christopher B, Hecht, Harvey S, Karas, Richard H, Judelson, Debra R, Naftolin, Frederick

“…The Women's Health Initiative (WHI) hormone replacement therapy (HRT) estrogen plus progestin (E+P) and estrogen-only arms are part of a large NIH-sponsored…”
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Is human aging still mysterious enough to be left only to scientists? by de Grey, Aubrey D.N.J., Baynes, John W., Berd, David, Heward, Christopher B., Pawelec, Graham, Stock, Gregory

“…The feasibility of reversing human aging within a matter of decades has traditionally been dismissed by all professional biogerontologists, on the grounds that…”
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Is there an antiaging medicine? by Butler, Robert N, Fossel, Michael, Harman, S Mitchell, Heward, Christopher B, Olshansky, S Jay, Perls, Thomas T, Rothman, David J, Rothman, Sheila M, Warner, Huber R, West, Michael D, Wright, Woodring E

“…In spite of considerable hype to the contrary, there is no convincing evidence that currently existing so-called "antiaging" remedies promoted by a variety of…”
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Relationship between Sunlight Exposure, Housing Condition, and Serum Vitamin D and Related Physiologic Biomarker Levels in Captive Chimpanzees (Pan troglodytes) by Videan, E.N, Heward, C.B, Fritz, J, Murphy, J, Cortez, C, Su, Y

“…In primates, the primary source of vitamin D is synthesis in the skin through sun exposure. Decreased sun exposure may lead to vitamin D deficiency and…”
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Whole genome association analysis shows that ACE is a risk factor for Alzheimer's disease and fails to replicate most candidates from Meta-analysis by Webster, Jennifer, Reiman, Eric M, Zismann, Victoria L, Joshipura, Keta D, Pearson, John V, Hu-Lince, Diane, Huentelman, Matthew J, Craig, David W, Coon, Keith D, Beach, Thomas, Rohrer, Kristen C, Zhao, Alice S, Leung, Doris, Bryden, Leslie, Marlowe, Lauren, Kaleem, Mona, Mastroeni, Diego, Grover, Andrew, Rogers, Joseph, Heun, Reinhard, Jessen, Frank, Kölsch, Heike, Heward, Christopher B, Ravid, Rivka, Hutton, Michael L, Melquist, Stacey, Petersen, Ron C, Caselli, Richard J, Papassotiropoulos, Andreas, Stephan, Dietrich A, Hardy, John, Myers, Amanda

“…For late onset Alzheimer's disease (LOAD), the only confirmed, genetic association is with the apolipoprotein E (APOE) locus on chromosome 19. Meta-analysis is…”
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