Search Results - "Hewagama, Anura"

Diversity in Hapten Recognition: Structural Study of an Anti-cocaine Antibody M82G2 by Pozharski, Edwin, Moulin, Aaron, Hewagama, Anura, Shanafelt, Armen B., Petsko, Gregory A., Ringe, Dagmar

“…Antibodies against cocaine and other drugs of abuse are the basis for diagnostic tests for the presence of those drugs in human serum. The 1.7 Å resolution…”
Get full text

The genetics and epigenetics of autoimmune diseases by Hewagama, Anura, Richardson, Bruce

“…Abstract Self tolerance loss is fundamental to autoimmunity. While understanding of immune regulation is expanding rapidly, the mechanisms causing loss of…”
Get full text

Overexpression of X-Linked genes in T cells from women with lupus by Hewagama, Anura, Gorelik, Gabriela, Patel, Dipak, Liyanarachchi, Punsisi, Joseph McCune, W, Somers, Emily, Gonzalez-Rivera, Tania, The Michigan Lupus Cohort, Strickland, Faith, Richardson, Bruce

“…Abstract Women develop lupus more frequently than men and the reason remains incompletely understood. Evidence that men with Klinefelter's Syndrome (XXY)…”
Get full text

Stronger inflammatory cytotoxic T-cell response in women identified by microarray analysis by Hewagama, A, Patel, D, Yarlagadda, S, Strickland, F M, Richardson, B C

“…Women develop chronic inflammatory autoimmune diseases more often than men. The mechanisms causing the increased susceptibility are incompletely understood…”
Get full text

Diet Influences Expression of Autoimmune‐Associated Genes and Disease Severity by Epigenetic Mechanisms in a Transgenic Mouse Model of Lupus by Strickland, Faith M., Hewagama, Anura, Wu, Ailing, Sawalha, Amr H., Delaney, Colin, Hoeltzel, Mark F., Yung, Raymond, Johnson, Kent, Mickelson, Barbara, Richardson, Bruce C.

“…Objective Lupus flares occur when genetically predisposed individuals encounter appropriate environmental agents. Current evidence indicates that the…”
Get full text

Functional Linkage between the Glutaminase and Synthetase Domains of Carbamoyl-phosphate Synthetase by Hewagama, Anura, Guy, Hedeel I., Vickrey, John F., Evans, David R.

“…Mammalian carbamoyl-phosphate synthetase is part of carbamoyl-phosphate synthetase-aspartate carbamoyltransferase-dihydroorotase (CAD), a multifunctional…”
Get full text

Environmental exposure, estrogen and two X chromosomes are required for disease development in an epigenetic model of lupus by Strickland, Faith M, Hewagama, Anura, Lu, Qianjian, Wu, Ailing, Hinderer, Robert, Webb, Ryan, Johnson, Kent, Sawalha, Amr H, Delaney, Colin, Yung, Raymond, Richardson, Bruce C

“…Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease primarily afflicting women. The reason for the gender bias is unclear, but genetic…”
Get full text

Stimulatory and Inhibitory Killer Ig-Like Receptor Molecules Are Expressed and Functional on Lupus T Cells by Basu, Dhiman, Liu, Ying, Wu, Ailing, Yarlagadda, Sushma, Gorelik, Gabriela J, Kaplan, Mariana J, Hewagama, Anura, Hinderer, Robert C, Strickland, Faith M, Richardson, Bruce C

“…T cells from lupus patients have hypomethylated DNA and overexpress genes normally suppressed by DNA methylation that contribute to disease pathogenesis. We…”
Get full text

Overexpression of X-Linked genes in T cells from women with lupus: Epigenetics: The Host and the immune response in autoimmunity by HEWAGAMA, Anura, GORELIK, Gabriela, PATEL, Dipak, LIYANARACHCHI, Punsisi, MCCUNE, W. Joseph, SOMERS, Emily, GONZALEZ-RIVERA, Tania, LUPUS COHORT, The Michigan, STRICKLAND, Faith, RICHARDSON, Bruce

Get full text

Evaluation of gender differences in methylation‐sensitive immune gene expression in T cells by cDNA microarray by Hewagama, Anura, Patel, Dipak, Yarlagadda, Sushma, Strickland, Faith M., Richardson, Bruce C.

“…Abstract only Previous studies in our laboratory have demonstrated that DNA methylation inhibitor 5‐aza‐2′‐deoxycytidine (5‐aza) demethylates DNA. T cell DNA…”
Get full text

Stimulatory and Inhibitory Killer Immunoglobulin-Like Receptor Molecules are Expressed and Functional on Lupus T Cells1 by Basu, Dhiman, Liu, Ying, Wu, Ailing, Yarlagadda, Sushma, Gorelik, Gabriela J., Kaplan, Mariana J., Hewagama, Anura, Hinderer, Robert C., Strickland, Faith M., Richardson, Bruce C.

“…T cells from lupus patients have hypomethylated DNA and overexpress genes normally suppressed by DNA methylation that contribute to disease pathogenesis. We…”
Get full text

Environmental exposure, estrogen and two X chromosomes are required for disease development in an epigenetic model of lupus: Gender, Sex Hormones, Pregnancy and Autoimmunity by STRICKLAND, Faith M, HEWAGAMA, Anura, RICHARDSON, Bruce C, QIANJIAN LU, AILING WU, HINDERER, Robert, WEBB, Ryan, JOHNSON, Kent, SAWALHA, Amr H, DELANEY, Colin, YUNG, Raymond

Get full text

Computational Prediction of c-MYC Binding and Action by Integration of Multiple Data Sources by Chen, Yili, Blackwell, Thomas W., Gao, Jing, Hewagama, Anura, Grifka, Heather M., Lee, Angel W., States, David J.

“…c-MYC is an important proto-oncogene. Its actions are mediated by sequence specific binding of the c-MYC protein to genomic DNA. While many c-MYC recognition…”
Get full text

Anchoring a Cationic Ligand: The Structure of the Fab Fragment of the Anti-morphine Antibody 9B1 and its Complex with Morphine by Pozharski, Edwin, Wilson, Mark A., Hewagama, Anura, Shanafelt, Armen B., Petsko, Gregory, Ringe, Dagmar

“…The crystal structures of an anti-morphine antibody 9B1 (to 1.6 Å resolution) and its complex with morphine (to 2.0 Å resolution) are reported. The…”
Get full text

Mechanism of glutamine hydrolysis and interdomain communication by mammalian carbamoyl phosphate synthetase by Hewagama, Anura

“…The synthesis of carbamoyl phosphate by the mammalian multifunctional protein, CAD, involves the concerted action of the 40-kDa amidotransferase domain (GLN),…”
Get full text

Functional linkage between the glutaminase and synthetase domains of carbamoyl-phosphate synthetase. Role of serine 44 in carbamoyl-phosphate synthetase-aspartate carbamoyltransferase-dihydroorotase (cad) by Hewagama, A, Guy, H I, Vickrey, J F, Evans, D R

“…Mammalian carbamoyl-phosphate synthetase is part of carbamoyl-phosphate synthetase-aspartate carbamoyltransferase-dihydroorotase (CAD), a multifunctional…”
Get full text

Diet Influences Expression of Autoimmune Associated Genes and Disease Severity By Epigenetic Mechanisms in a Transgenic Lupus Model by Strickland, Faith M., Hewagama, Anura, Wu, Ailing, Sawalha, Amr H., Delaney, Colin, Hoeltzel, Mark F., Yung, Raymond, Johnson, Kent, Mickelson, Barbara, Richardson, Bruce C.

Get full text

The function of Glu338 in the catalytic triad of the carbamoyl phosphate synthetase amidotransferase domain by Hewagama, Anura, Guy, Hedeel I., Chaparian, Michael, Evans, David R.

Get full text

The function of Glu 338 in the catalytic triad of the carbamoyl phosphate synthetase amidotransferase domain by Hewagama, Anura, Guy, Hedeel I., Chaparian, Michael, Evans, David R.

“…The synthesis of carbamoyl phosphate by the mammalian multifunctional protein, CAD, involves the concerted action of the 40 kDa amidotransferase domain (GLN),…”
Get full text