Search Results - "Heunks, L"

Computational physiological models for individualised mechanical ventilation: a systematic literature review focussing on quality, availability, and clinical readiness by Warnaar, R S P, Mulder, M P, Fresiello, L, Cornet, A D, Heunks, L M A, Donker, D W, Oppersma, E

“…Individualised optimisation of mechanical ventilation (MV) remains cumbersome in modern intensive care medicine. Computerised, model-based support systems…”
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Absence of COVID-19 associated mucormycosis in a tertiary intensive care unit in the Netherlands by Schippers, J. R., Verweij, P. E., Heunks, L. M. A., van Dijk, K.

“…Mucormycosis is a severe complication in critically ill COVID-19 patients. Throughout the pandemic, a notable prevalence of mucormycosis has been observed in…”
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Analysis and applications of respiratory surface EMG: report of a round table meeting by Jonkman, A H, Warnaar, R S P, Baccinelli, W, Carbon, N M, D'Cruz, R F, Doorduin, J, van Doorn, J L M, Elshof, J, Estrada-Petrocelli, L, Graßhoff, J, Heunks, L M A, Koopman, A A, Langer, D, Moore, C M, Nunez Silveira, J M, Petersen, E, Poddighe, D, Ramsay, M, Rodrigues, A, Roesthuis, L H, Rossel, A, Torres, A, Duiverman, M L, Oppersma, E

“…Surface electromyography (sEMG) can be used to measure the electrical activity of the respiratory muscles. The possible applications of sEMG span from patients…”
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Three bedside techniques to quantify dynamic pulmonary hyperinflation in mechanically ventilated patients with chronic obstructive pulmonary disease by Roesthuis, L. H., van der Hoeven, J. G., Guérin, C., Doorduin, J., Heunks, L. M. A.

“…Background Dynamic pulmonary hyperinflation may develop in patients with chronic obstructive pulmonary disease (COPD) due to dynamic airway collapse and/or…”
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Recruitment pattern of the diaphragm and extradiaphragmatic inspiratory muscles in response to different levels of pressure support by Roesthuis, L. H., van der Hoeven, J. G., van Hees, H. W. H., Schellekens, W.-J. M., Doorduin, J., Heunks, L. M. A.

“…Background Inappropriate ventilator assist plays an important role in the development of diaphragm dysfunction. Ventilator under-assist may lead to muscle…”
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Lung ultrasound to predict gas-exchange response to prone positioning in COVID-19 patients: A prospective study in pilot and confirmation cohorts by Heldeweg, M.L.A., Mousa, A., van Ekeren, J., Lieveld, A.W.E., Walburgh-Schmidt, R.S., Smit, J.M., Haaksma, M.E., de Grooth, H.J., Heunks, L.M.A., Tuinman, P.R.

“…To examine whether lung ultrasound prior to prone positioning can predict the resulting gas-exchange response. This is a prospective observational study on…”
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The effect of metabolic alkalosis on the ventilatory response in healthy subjects by Oppersma, E., Doorduin, J., van der Hoeven, J.G., Veltink, P.H., van Hees, H.W.H., Heunks, L.M.A.

“…•Plasma bicarbonate increased in healthy subjects by ingesting sodium bicarbonate.•With increasing inspiratory CO2 pressure, breathing parameters…”
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The effect of immunosuppressive therapies on the endothelial host response in critically ill COVID-19 patients by Slim, M. A., Lim, E. H. T., van Vught, L. A., Boer, A. M. Tuip-de, Rademaker, E., Mulier, J. L. G. Haitsma, Engel, J. J., Pickkers, P., van de Veerdonk, F. L., Vlaar, A. P. J., Derde, L. P. G., Juffermans, N. P.

“…While several effective therapies for critically ill patients with COVID-19 have been identified in large, well-conducted trials, the mechanisms underlying…”
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Levosimendan: current data, clinical use and future development by Nieminen, M S, Fruhwald, S, Heunks, L M A, Suominen, P K, Gordon, A C, Kivikko, M, Pollesello, P

“…Levosimendan is an inodilator indicated for the short-term treatment of acutely decompensated severe chronic heart failure, and in situations where…”
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Multi-organ point-of-care ultrasound for detection of pulmonary embolism in critically ill COVID-19 patients – A diagnostic accuracy study by Lieveld, Arthur, Heldeweg, M.L.A., Smit, J.M., Haaksma, M.E., Veldhuis, L., Walburgh-Schmidt, R.S., Twisk, J., Nanayakkara, P.W.B., Heunks, L., Tuinman, P.R.

“…Critically ill COVID-19 patients have an increased risk of developing pulmonary embolism (PE). Diagnosis of PE by point-of-care ultrasound (POCUS) might reduce…”
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Levosimendan improves calcium sensitivity of diaphragm muscle fibres from a rat model of heart failure by van Hees, HWH, Andrade Acuña, GL, Linkels, M, Dekhuijzen, PNR, Heunks, LMA

“…BACKGROUND AND PURPOSE Diaphragm muscle weakness occurs in patients with heart failure (HF) and is associated with exercise intolerance and increased…”
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Levosimendan in intensive care and emergency medicine: literature update and expert recommendations for optimal efficacy and safety by Girardis, M, Bettex, D, Bojan, M, Demponeras, C, Fruhwald, S, Gál, J, Groesdonk, H V, Guarracino, F, Guerrero-Orriach, J L, Heringlake, M, Herpain, A, Heunks, L, Jin, J, Kindgen-Milles, D, Mauriat, P, Michels, G, Psallida, V, Rich, S, Ricksten, S-E, Rudiger, A, Siegemund, M, Toller, W, Treskatsch, S, Župan, Ž, Pollesello, P

“…The inodilator levosimendan, in clinical use for over two decades, has been the subject of extensive clinical and experimental evaluation in various clinical…”
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Heart failure decreases passive tension generation of rat diaphragm fibers by van Hees, H.W.H, Ottenheijm, C.A.C, Granzier, H.L, Dekhuijzen, P.N.R, Heunks, L.M.A

“…Abstract Background Diaphragm dysfunction is well-known to limit quality of life and prognosis of patients with heart failure (HF), but its underlying…”
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Respiratory muscle function and free radicals: from cell to COPD by Heunks, Leo M A, Dekhuijzen, P N Richard

“…Free radicals and antioxidants in striated muscle contractility Free radicals are molecules capable of independent existence which contain one or more single…”
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Ventilation Strategies for Acute Lung Injury and Acute Respiratory Distress Syndrome by Heunks, L. M. A, van der Hoeven, J. G

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Resveratrol attenuates NF-[kappa]B-binding activity but not cytokine production in mechanically ventilated mice by Wal, S E I, Vaneker, M, Kox, M, Braak, G, Hees, H W H, Brink, I A, Pol, F M, Heunks, L M, Hoeven, J G, Joosten, L A B, Vissers, K C P, Scheffer, G J

“…Background Mechanical ventilation (MV) can result in inflammation and subsequent lung injury. Toll-like receptor (TLR)4 and NF-[kappa]B are proposed to play a…”
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Diaphragm dysfunction in chronic obstructive pulmonary disease: a role for heparan sulphate? by Ottenheijm, C. A. C, Jenniskens, G. J, Geraedts, M. C. P, Hafmans, T, Heunks, L. M. A, van Kuppevelt, T. H, Dekhuijzen, P. N. R

“…In the present study, phage display-derived antibodies were used to investigate the topology of glycosaminoglycan epitopes in the diaphragm of chronic…”
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Resveratrol attenuates NF-κB-binding activity but not cytokine production in mechanically ventilated mice by VAN DER WAL, S. E. I., VANEKER, M., KOX, M., BRAAK, G., VAN HEES, H. W. H., VAN DEN BRINK, I. A., VAN DE POL, F. M., HEUNKS, L. M., VAN DER HOEVEN, J. G., JOOSTEN, L. A. B., VISSERS, K. C. P., SCHEFFER, G. J.

“…Background Mechanical ventilation (MV) can result in inflammation and subsequent lung injury. Toll‐like receptor (TLR)4 and NF‐κB are proposed to play a…”
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Isoflurane attenuates pulmonary interleukin-1β and systemic tumor necrosis factor-α following mechanical ventilation in healthy mice by VANEKER, M., SANTOSA, J. P., HEUNKS, L. M., HALBERTSMA, F. J., SNIJDELAAR, D. G., VAN EGMOND, J., VAN DEN BRINK, I. A., VAN DE POL, F. M., VAN DER HOEVEN, J. G., SCHEFFER, G. J.

“…Background: Mechanical ventilation (MV) induces an inflammatory response in healthy lungs. The resulting pro‐inflammatory state is a risk factor for…”
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Role of nitric oxide in isometric contraction properties of rat diaphragm during hypoxia by Zhu, Xiaoping, Heunks, L M A, Ennen, L, Machiels, H A, Dekhuijzen, P N R

“…Hypoxia disturbs Ca(2+) regulation and increases the intracellular Ca(2+) concentration ([Ca(2+)](i)), which may in turn activate the nitric oxide synthase…”
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