Search Results - "Heufler, C"

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10 by Koch, F, Stanzl, U, Jennewein, P, Janke, K, Heufler, C, Kämpgen, E, Romani, N, Schuler, G

“…We have shown previously that dendritic cells (DC) produce IL-12 upon interaction with CD4+ T cells. Here we ask how this IL-12 production is induced and…”
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Production of IL-12 by Human Monocyte-Derived Dendritic Cells Is Optimal When the Stimulus Is Given at the Onset of Maturation, and Is Further Enhanced by IL-4 by Ebner, Susanne, Ratzinger, Gudrun, Krosbacher, Beate, Schmuth, Matthias, Weiss, Angelika, Reider, Daniela, Kroczek, Richard A, Herold, Manfred, Heufler, Christine, Fritsch, Peter, Romani, Nikolaus

“…Dendritic cells produce IL-12 both in response to microbial stimuli and to T cells, and can thus skew T cell reactivity toward a Th1 pattern. We investigated…”
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Expression of the C-C chemokine MIP-3α/CCL20 in human epidermis with impaired permeability barrier function by Schmuth, M., Neyer, S., Rainer, C., Grassegger, A., Fritsch, P., Romani, N., Heufler, C.

“…: External assault to the skin is followed by an epidermal response including synthesis of DNA, lipids, cytokines and migration of antigen presenting cells…”
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In vitro treatment of dendritic cells with tacrolimus: impaired T-cell activation and IP-10 expression by Tiefenthaler, Martin, Hofer, Susanne, Ebner, Susanne, Ivarsson, Lennart, Neyer, Susanne, Herold, Manfred, Mayer, Gert, Fritsch, Peter, Heufler, Christine

“…Background. High doses (10–6–10–8 M) of tacrolimus (FK506) were reported to induce a type-2 T-helper cell (Th2)-promoting function in developing dendritic…”
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236 Disrupted keratinocyte differentiation and increased chemokine and antimicrobial peptide expression in palmoplantar keratoderma due to keratin 9 mutation by Ortner-Tobider, D., Trafoier, T., Mildner, M., Heufler, C., Schmuth, M.

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Interleukin 7 is produced by murine and human keratinocytes by HEUFLER, C, TOPAR, G, GRASSEGER, A, STANZL, U, KOCH, F, ROMANI, N, NAMEN, A. E, SCHULER, G

“…Interleukin 7 (IL-7) was originally identified as a growth factor for B cell progenitors, and subsequently has been shown to exert proliferative effects on T…”
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159 CRISPR/Cas9 nickase mediated gene therapy in primary keratinocytes derived from patients with EPPK by Trafoier, T., Hainzl, S., Kocher, T., Koller, U., Reichelt, J., Tiefenthaler, C Heufler, Schmuth, M.

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Substance P and Vasoactive Intestinal Polypeptide in the Streptozotocin-Induced Diabetic Rat Retina by Troger, Josef, Neyer, Susanne, Heufler, Christine, Huemer, Hartwig, Schmid, Eduard, Griesser, Ute, Kralinger, Martina, Kremser, Bernhard, Baldissera, Ivo, Kieselbach, Gerhard

“…Little knowledge exists about how neurotransmitters behave in the diabetic retina. In this study, the authors measured the concentration of two neuropeptides,…”
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Cytokine gene expression in murine epidermal cell suspensions : interleukin 1β and macrophage inflammatory protein 1α are selectively expressed in Langerhans cells but are differentially regulated in culture by HEUFLER, C, TOPAR, G, KOCH, F, TROCKENBACHER, B, KÄMPGEN, E, ROMANI, N, SCHULER, G

“…Epidermal Langerhans cells (LC) are considered direct yet immature precursors of dendritic cells (DC) in the draining lymph nodes. Although the development of…”
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GTP cyclohydrolase I mRNA: novel splice variants in the slime mould Physarum polycephalum and in human monocytes (THP-1) indicate conservation of mRNA processing by Golderer, G, Werner, E R, Heufler, C, Strohmaier, W, Gröbner, P, Werner-Felmayer, G

“…GTP cyclohydrolase I (EC 3.5.4.16) is the first enzyme in the biosynthesis of tetrahydrobiopterin [(6R)-5,6,7,8-tetrahydro-L-biopterin, H(4)-biopterin] in…”
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803 Editing a missense to a nonsense keratin 9 gene mutation restores intermediate filament integrity by Trafoier, T., Ortner-Tobider, D., Hainzl, S., Kocher, T., Koller, U., Bauer, J., Rhiel, M., Andrieux, G., Cornu, T., Cathomen, T., Reichelt, J., Tiefenthaler, C. Heufler, Schmuth, M.

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Disappearance of certain acidic organelles (endosomes and langerhans cell granules) accompanies loss of antigen processing capacity upon culture of epidermal langerhans cells by STOÊSSEL, H, KOCH, F, KAÊMPGEN, E, STOÊGER, P, LENZ, A, HEUFLER, C, ROMANI, N, SCHULER, G

“…Freshly isolated epidermal Langerhans cells (LC) can actively process native protein antigens, but are weak in sensitizing helper T cells. During culture, when…”
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Class II Major Histocompatibility Complex Molecules of Murine Dendritic Cells: Synthesis, Sialylation of Invariant Chain, and Antigen Processing Capacity are Down-Regulated Upon Culture by Kampgen, Eckhart, Koch, Norbert, Koch, Franz, Stoger, Peter, Heufler, Christine, Schuler, Gerold, Romani, Nikolaus

“…Dendritic cells (DCs), such as Langerhans cells (LCs) of the epidermis and the DCs of lymphoid organs such as spleen, are potent antigen presenting cells. DCs…”
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293 Identification of amino acids that equip lipocalins with allergenic potential by Klaver, D.D., Posch, B., Geisler, A., Reider, N., Redl, B., Heufler, C.

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The immunomodulator FTY720 interferes with effector functions of human monocyte‐derived dendritic cells by Müller, Hansgeorg, Hofer, Susanne, Kaneider, Nicole, Neuwirt, Hannes, Mosheimer, Birgit, Mayer, Gert, Konwalinka, Günther, Heufler, Christine, Tiefenthaler, Martin

“…The potent immunomodulator FTY720 elicits immunosuppression via acting on sphingosine 1‐phosphate receptors (S1PR), thereby leading to an entrapment of…”
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Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells by Heufler, C, Koch, F, Stanzl, U, Topar, G, Wysocka, M, Trinchieri, G, Enk, A, Steinman, R M, Romani, N, Schuler, G

“…Interleukin-12 (IL-12), a 70-kDa heterodimeric cytokine composed of covalently linked p35 and p40 chains, is to date the most critical factor for skewing the…”
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A molecular strategy to identify molecules that are specific for dendritic cells and/or critical to their unique immunostimulatory function by Heufler, C, Humborg, C, Steinman, R M, Schuler, G, Nussenzweig, M

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Murine Epidermal Langerhans Cells Express Significant Amounts of Class I Major Histocompatibility Complex Antigens by Lenz, Angela, Heufler, Christine, Rammensee, Hans-Georg, Glassl, Herta, Koch, Franz, Romani, Nikolaus, Schuler, Gerold

“…Epidermal Langerhans cells (LC) are leukocytes that express major histocompatibility complex (MHC) class II antigens and function as antigen-presenting and…”
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The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing by Jiang, Wanping, Swiggard, William J, Heufler, Christine, Peng, Michael, Mirza, Asra, Steinman, Ralph M, Nussenzweig, Michel C

“…Dendritic cells and thymic epithelial cells perform important immunoregulatory functions by presenting antigens in the form of peptides bound to cell-surface…”
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A Novel Role for IL-3: Human Monocytes Cultured in the Presence of IL-3 and IL-4 Differentiate into Dendritic Cells That Produce Less IL-12 and Shift Th Cell Responses Toward a Th2 Cytokine Pattern by Ebner, Susanne, Hofer, Susanne, Nguyen, Van Anh, Furhapter, Christina, Herold, Manfred, Fritsch, Peter, Heufler, Christine, Romani, Nikolaus

“…Dendritic cells (DC) derived from plasmacytoid precursors depend on IL-3 for survival and proliferation in culture, and they induce preferentially Th2…”
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