Search Results - "Heuberger, A"

Effect of sustained high buprenorphine plasma concentrations on fentanyl-induced respiratory depression: A placebo-controlled crossover study in healthy volunteers and opioid-tolerant patients by Moss, Laurence M, Algera, Marijke Hyke, Dobbins, Robert, Gray, Frank, Strafford, Stephanie, Heath, Amy, van Velzen, Monique, Heuberger, Jules A A C, Niesters, Marieke, Olofsen, Erik, Laffont, Celine M, Dahan, Albert, Groeneveld, Geert Jan

“…Opioid-induced respiratory depression driven by ligand binding to mu-opioid receptors is a leading cause of opioid-related fatalities. Buprenorphine, a partial…”
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EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis by Hidalgo, Daniel, Bejder, Jacob, Pop, Ramona, Gellatly, Kyle, Hwang, Yung, Maxwell Scalf, S., Eastman, Anna E., Chen, Jane-Jane, Zhu, Lihua Julie, Heuberger, Jules A. A. C., Guo, Shangqin, Koury, Mark J., Nordsborg, Nikolai Baastrup, Socolovsky, Merav

“…The erythroid terminal differentiation program couples sequential cell divisions with progressive reductions in cell size. The erythropoietin receptor (EpoR)…”
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Repeatability and predictive value of lactate threshold concepts in endurance sports by Heuberger, Jules A A C, Gal, Pim, Stuurman, Frederik E, de Muinck Keizer, Wouter A S, Mejia Miranda, Yuri, Cohen, Adam F

“…Blood lactate concentration rises exponentially during graded exercise when muscles produce more lactate than the body can remove, and the blood…”
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The Frailty Syndrome: A Comprehensive Review by Heuberger, Roschelle A.

“…The frailty syndrome is defined as unintentional weight and muscle loss, exhaustion, and declines in grip strength, gait speed, and activity. Evidence with…”
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Nonalcoholic fatty liver disease: an independent risk factor for colorectal neoplasia by Stadlmayr, A., Aigner, E., Steger, B., Scharinger, L., Lederer, D., Mayr, A., Strasser, M., Brunner, E., Heuberger, A., Hohla, F., Steinwendner, J., Patsch, W., Datz, C.

“…Stadlmayr A, Aigner E, Steger B, Scharinger L, Lederer D, Mayr A, Strasser M, Brunner E, Heuberger A, Hohla F, Steinwendner J, Patsch W, Datz C (Oberndorf…”
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Inappropriate Study Design Produces Spurious Effects of Autologous Blood Transfusion by HEUBERGER, JULES A. A C, COHEN, ADAM F

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A leucine‐rich repeat kinase 2 (LRRK2) pathway biomarker characterization study in patients with Parkinson's disease with and without LRRK2 mutations and healthy controls by Vissers, Maurits F. J. M., Troyer, Matthew D., Thijssen, Eva, Pereira, Diana R., Heuberger, | Jules A. A. C., Groeneveld, Geert Jan, Huntwork‐Rodriguez, Sarah

“…Increased leucine‐rich repeat kinase 2 (LRRK2) kinase activity is an established risk factor for Parkinson's disease (PD), and several LRRK2 kinase inhibitors…”
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Targeting for Success: Demonstrating Proof-of-Concept with Mechanistic Early Phase Clinical Pharmacology Studies for Disease-Modification in Neurodegenerative Disorders by Vissers, Maurits F J M, Heuberger, Jules A A C, Groeneveld, Geert Jan

“…The clinical failure rate for disease-modifying treatments (DMTs) that slow or stop disease progression has been nearly 100% for the major neurodegenerative…”
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Population Pharmacokinetic Model of THC Integrates Oral, Intravenous, and Pulmonary Dosing and Characterizes Short- and Long-term Pharmacokinetics by Heuberger, Jules A. A. C., Guan, Zheng, Oyetayo, Olubukayo-Opeyemi, Klumpers, Linda, Morrison, Paul D., Beumer, Tim L., van Gerven, Joop M. A., Cohen, Adam F., Freijer, Jan

“…Δ 9 -Tetrahydrocannobinol (THC), the main psychoactive compound of Cannabis, is known to have a long terminal half-life. However, this characteristic is often…”
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Transcranial magnetic stimulation as a translational biomarker for AMPA receptor modulation by O’Donnell, Patricio, Dijkstra, Francis M., Damar, Ugur, Quanhong, Lei, de Goede, Annika A., Xu, Lin, Pascual-Leone, Andres, Buhl, Derek L., Zuiker, Rob, Ruijs, Titia Q., Heuberger, Jules A. A. C., MacMullin, Paul, Lubell, Martin, Asgharnejad, Mahnaz, Murthy, Venkatesha, Rotenberg, Alexander, Jacobs, Gabriel E., Rosen, Laura

“…TAK-653 is a novel α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-positive allosteric modulator being developed as a potential…”
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Muscle velocity recovery cycles as pharmacodynamic biomarker: Effects of mexiletine in a randomized double‐blind placebo‐controlled cross‐over study by Ruijs, Titia Q., Koopmans, Ingrid W., Kam, Marieke L., Tannemaat, Martijn R., Groeneveld, Geert Jan, Heuberger, Jules A. A. C.

“…Measuring muscle velocity recovery cycles (MVRCs) is a method to obtain information on muscle cell excitability, independent of neuromuscular transmission. The…”
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Companion-Animal Caregiver Knowledge, Attitudes, and Beliefs Regarding End-of-Life Care by Heuberger, Roschelle A., Pierce, Jessica

“…Although awareness of end-of-life care is growing within the veterinary field and there appears to be consumer demand for these services, it is unclear exactly…”
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Erythropoietin doping in cycling: lack of evidence for efficacy and a negative risk–benefit by Heuberger, Jules A. A. C., Cohen Tervaert, Joost M., Schepers, Femke M. L., Vliegenthart, Adriaan D. B., Rotmans, Joris I., Daniels, Johannes M. A., Burggraaf, Jacobus, Cohen, Adam F.

“…Imagine a medicine that is expected to have very limited effects based upon knowledge of its pharmacology and (patho)physiology and that is studied in the…”
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Additive effect of erythropoietin use on exercise-induced endothelial activation and hypercoagulability in athletes by Heuberger, Jules A. A. C., Posthuma, Jelle J., Ziagkos, Dimitrios, Rotmans, Joris I., Daniels, Johannes M. A., Gal, Pim, Stuurman, Frederik E., Spronk, Henri M. H., Ten Cate, Hugo, Burggraaf, Jacobus, Moerland, Matthijs, Cohen, Adam F.

“…Purpose Recombinant human erythropoietin (rHuEPO) is known to increase thrombotic risk in patients and might have similar effects in athletes abusing the drug…”
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Metabolomic profile of embryo culture medium on day 3 is associated with subsequent blastocyst development by Krisher, R.L, Greene, A.F, Stevens, J, Heuberger, A, Schoolcraft, W.B

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Elevated maternal BMI results in severely disrupted blastocyst metabolism by Krisher, R.L, Greene, A.F, Stevens, J, Heuberger, A, Schoolcraft, W.B

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Acute retigabine‐induced effects on myelinated motor axons in amyotrophic lateral sclerosis by Sleutjes, Boudewijn T. H. M., Stikvoort García, Diederik J. L., Kovalchuk, Maria O., Heuberger, Jules A. A. C., Groeneveld, Geert Jan, Franssen, Hessel, Berg, Leonard H.

“…Altered motor neuron excitability in patients with amyotrophic lateral sclerosis (ALS) has been suggested to be an early pathophysiological mechanism…”
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Gender‐ and site‐specific differences of colorectal neoplasia relate to vitamin D by Aigner, E., Stadlmayr, A., Huber‐Schönauer, U., Zwerina, J., Husar‐Memmer, E., Niederseer, D., Trauner, M., Heuberger, A., Hohla, F., Schett, G., Patsch, W., Datz, C.

“…Summary Background The effect of vitamin D on colorectal adenomas may vary with regard to gender, localisation and histological type of the lesion. Aim To…”
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315. Diverting ileostomy versus no diversion after low anterior resection for rectal cancer: A prospective, randomized, multicenter trial by Mrak, K, Uranitsch, S, Pedross, F, Heuberger, A, Klingler, A, Jagoditsch, M, Weihs, D, Eberl, T, Tschmelitsch, J

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Recombinant human erythropoietin does not affect several microvascular parameters in well‐trained cyclists by Birkhoff, Willem A. J., Heuberger, Jules A. A. C., Post, Titiaan E., Gal, Pim, Stuurman, Frederik E., Burggraaf, Jacobus, Cohen, Adam F.

“…Recombinant human erythropoietin (rHuEPO) has been used as a performance‐enhancing agent by athletes in a variety of sports. The resulting increase in…”
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