Search Results - "Heubach, Jürgen F."

Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score by De Jager, Philip L, MD, Chibnik, Lori B, PhD, Cui, Jing, PhD, Reischl, Joachim, PhD, Lehr, Stephan, PhD, Simon, K Claire, PhD, Aubin, Cristin, BS, Bauer, David, PhD, Heubach, Jürgen F, MD, Sandbrink, Rupert, MD, Tyblova, Michaela, MD, Lelkova, Petra, MD, Havrdova, Eva, MD, Pohl, Christoph, MD, Horakova, Dana, MD, Ascherio, Alberto, MD, Hafler, David A, MD, Karlson, Elizabeth W, MD

“…Summary Background Prediction of susceptibility to multiple sclerosis (MS) might have important clinical applications, either as part of a diagnostic algorithm…”
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Role of IKur in controlling action potential shape and contractility in the human atrium: Influence of chronic atrial fibrillation by WETTWER, Erich, HALA, Otto, CHRIST, Torsten, HEUBACH, Jürgen F, DOBREV, Dobromir, KNAUT, Michael, VARRO, Andras, RAVENS, Ursula

“…The ultrarapid outward current I(Kur) is a major repolarizing current in human atrium and a potential target for treating atrial arrhythmias. The effects of…”
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Electrophysiological properties of human mesenchymal stem cells by Heubach, Jürgen F., Graf, Eva M., Leutheuser, Judith, Bock, Manja, Balana, Bartosz, Zahanich, Ihor, Christ, Torsten, Boxberger, Sabine, Wettwer, Erich, Ravens, Ursula

“…Human mesenchymal stem cells (hMSC) have gained considerable interest due to their potential use for cell replacement therapy and tissue engineering. One…”
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Molecular and Functional Expression of Voltage‐Operated Calcium Channels During Osteogenic Differentiation of Human Mesenchymal Stem Cells by Zahanich, Ihor, Graf, Eva M, Heubach, Jürgen F, Hempel, Ute, Boxberger, Sabine, Ravens, Ursula

“…We used the patch‐clamp technique and RT‐PCR to study the molecular and functional expression of VOCCs in undifferentiated hMSCs and in cells undergoing…”
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Specific β2AR blocker ICI 118,551 actively decreases contraction through a Gi-Coupled form of the β2AR in myocytes from failing human heart by GONG, Haibin, HONG SUN, KOCH, Walter J, RAU, Thomas, ESCHENHAGEN, Thomas, RAVENS, Ursula, HEUBACH, Jürgen F, ADAMSON, Dawn L, HARDING, Sian E

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Recovery of microarray-quality RNA from frozen EDTA blood samples by Beekman, Johanna M., Reischl, Joachim, Henderson, David, Bauer, David, Ternes, Rainer, Peña, Carol, Lathia, Chetan, Heubach, Jürgen F.

“…The availability of blood collection systems with RNA stabilizing additives (e.g. PAXgene) has opened the field for gene expression profiling in large…”
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Reduction of hERG potassium currents by hyperosmolar solutions by Yabuuchi, Fumie, Beckmann, Rolf, Wettwer, Erich, Hegele-Hartung, Christa, Heubach, Jürgen F.

“…We investigated the effects of hyperosmolar solutions on human ether-a-go-go related gene (hERG) potassium currents in chinese hamster ovary (CHO) cells. The…”
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Increased Expression of Wnt5a in Psoriatic Plaques by Reischl, Joachim, Schwenke, Susanne, Beekman, Johanna M., Mrowietz, Ulrich, Stürzebecher, Steffen, Heubach, Jürgen F.

“…Psoriasis vulgaris is characterized by hyperproliferation and incomplete terminal differentiation of epidermal keratinocytes. Despite the established role of…”
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Aconitum sp. alkaloids: the modulation of voltage-dependent Na + channels, toxicity and antinociceptive properties by Friese, Jutta, Gleitz, Johannes, Gutser, Ulrike T, Heubach, Jürgen F, Matthiesen, Theo, Wilffert, Bob, Selve, Norma

“…Alkaloids from Aconitum sp., used as analgesics in traditional Chinese medicine, were investigated to elucidate their antinociceptive and toxic properties…”
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The effect of Gi‐protein inactivation on basal, and β1‐ and β2AR‐stimulated contraction of myocytes from transgenic mice overexpressing the β2‐adrenoceptor by Gong, Haibin, Adamson, Dawn L, Ranu, Hardeep K, Koch, Walter J, Heubach, Jürgen F, Ravens, Ursula, Zolk, Oliver, Harding, Sian E

“…The atria and ventricles of transgenic mice (TGβ2) with cardiac overexpression of the human β2‐adrenoceptor (β2AR) were initially reported to show maximum…”
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Biological response genes after single dose administration of interferon β-1b to healthy male volunteers by Hilpert, Jan, Beekman, Johanna M, Schwenke, Susanne, Kowal, Kristin, Bauer, David, Lampe, Johannes, Sandbrink, Rupert, Heubach, Jürgen F, Stürzebecher, Steffen, Reischl, Joachim

“…Abstract Treatment with interferon β-1b (IFNB-1b) is clinically effective in multiple sclerosis patients. However, the mechanism of action is only partially…”
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Physiological antagonism between ventricular β1‐adrenoceptors and α1‐adrenoceptors but no evidence for β2‐ and β3‐adrenoceptor function in murine heart by Heubach, Jürgen F, Rau, Thomas, Eschenhagen, Thomas, Ravens, Ursula, Kaumann, Alberto J

“…Murine left atrium lacks inotropic β2‐adrenoceptor function. We investigated whether β2‐adrenoceptors are involved in the cardiostimulant effects of…”
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Cardiostimulant and cardiodepressant effects through overexpressed human β2-adrenoceptors in murine heart: regional differences and functional role of β1-adrenoceptors by Heubach, Jürgen F., Blaschke, Marianne, Harding, Sian E., Ravens, Ursula, Kaumann, Alberto J.

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Signals from Embryonic Fibroblasts Induce Adult Intestinal Epithelial Cells to Form Nestin‐Positive Cells with Proliferation and Multilineage Differentiation Capacity In Vitro by Wiese, Cornelia, Rolletschek, Alexandra, Kania, Gabriela, Navarrete‐Santos, Anne, Anisimov, Sergey V., Steinfarz, Barbara, Tarasov, Kirill V., Brugh, Sheryl A., Zahanich, Ihor, Rüschenschmidt, Christiane, Beck, Heinz, Blyszczuk, Przemyslaw, Czyz, Jaroslaw, Heubach, Jürgen F., Ravens, Ursula, Horstmann, Olaf, St‐Onge, Luc, Braun, Thomas, Brüstle, Oliver, Boheler, Kenneth R., Wobus, Anna M.

“…The intestinal epithelium has one of the greatest regenerative capacities in the body; however, neither stem nor progenitor cells have been successfully…”
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T-Type and tetrodotoxin-sensitive Ca(2+) currents coexist in guinea pig ventricular myocytes and are both blocked by mibefradil by Heubach, J F, Köhler, A, Wettwer, E, Ravens, U

“…Under Na(+)-free conditions, low-voltage-activated Ca(2+) currents in cardiomyocytes from various species have been described either as Ni(2+)-sensitive T-type…”
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T-Type and Tetrodotoxin-Sensitive Ca2 Currents Coexist in Guinea Pig Ventricular Myocytes and Are Both Blocked by Mibefradil by Heubach, Jürgen F, Köhler, Arndt, Wettwer, Erich, Ravens, Ursula

“…ABSTRACTUnder Na-free conditions, low-voltage–activated Ca currents in cardiomyocytes from various species have been described either as Ni-sensitive T-type Ca…”
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Rivaroxaban compared with standard anticoagulants for the treatment of acute venous thromboembolism in children: a randomised, controlled, phase 3 trial by Palumbo, Joseph S, Nurmeev, Ildar, Hege, Kerry, Bonnet, Damien, Connor, Philip, Hooimeijer, Hélène L, Torres, Marcela, Kenet, Gili, Holzhauer, Susanne, Santamaría, Amparo, Amedro, Pascal, Chalmers, Elizabeth, Simioni, Paolo, Beyer-Westendorf, Jan, Biss, Tina T, Martinelli, Ida, Saracco, Paola, Peters, Marjolein, Kállay, Krisztián, Gauger, Cynthia A, Massicotte, M Patricia, Young, Guy, Majumder, Madhurima, Smith, William T, Berkowitz, Scott D, Thelen, Kirstin, Kubitza, Dagmar, Crowther, Mark, Prins, Martin H, Monagle, Paul, Nowak Göttl, Ulrike, Robertson, Jeremy, Thom, Katharina, Streif, Werner, Schwarz, Rudolf, Schmitt, Klaus, Grangl, Gernot, Van Damme, An, Maes, Philip, Labarque, Veerle, Petrilli, Antonio, Azeka, Estela, Brandao, Leonardo, Le, Doan, Giordano, Paola, Ding, Jie, Huang, Wenyan, Mao, Jianhua, Lähteenmäki, Päivi, Amedro, Pascal, Decramer, Stephane, Bernig, Toralf, Chada, Martin, Chan, Godfrey, Kally, Krisztian, Nolan, Beatrice, Revel-Vilk, Shoshana, Tamary, Hannah, Levin, Carina, Abbattista, Maria, Inuzuka, Ryo, Morales Soto, Michelle, Solis Labastida, Karina A, Suijker, Monique H, Bartels, Marike, Tamminga, Rienk Y, Te Loo, D. Maroeska, Anjos, Rui, Zubarovskaya, Lyudmila, Popova, Natalia, Svirin, Pavel, Koh, Pei L, Mei, Joyce C, Berrueco, Ruben, Fernandez, Maria F, Frisk, Tony, Albisetti-Pedroni, Manuela, Antmen, Ali, Karakas, Zeynep, Chalmers, Elizabeth, Motwani, Jayashree, Williams, Michael, Grainger, John, Richards, Mike, Baird, Susan, Bhatnagar, Neha, Aramburo, Angela, Crary, Shelley, Wynn, Tung, Hege, Kerry, Ahuja, Sanjay, Goldenberg, Neil, Godder, Kamar, Scott-Emuakpor, Ajovi, Roach, Gavin, Raffini, Leslie, Shah, Nirmish, Shah, Sanjay, Thornburg, Courtney, Zia, Ayesha

“…Treatment of venous thromboembolism in children is based on data obtained in adults with little direct documentation of its efficacy and safety in children…”
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Effects of azelastine on contractility, action potentials and L-type Ca2+ current in guinea pig cardiac preparations by SHENGNAN LI, BLASCHKE, Marianne, HEUBACH, Jürgen F, WETTWER, Erich, RAVENS, Ursula

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Murine ventricular L‐type Ca2+ current is enhanced by zinterol viaβ1‐adrenoceptors, and is reduced in TG4 mice overexpressing the human β2‐adrenoceptor by Heubach, Jürgen F, Graf, Eva M, Molenaar, Peter, Jäger, Andreas, Schröder, Frank, Herzig, Stefan, Harding, Sian E, Ravens, Ursula

“…The functional coupling of β2‐adrenoceptors (β2‐ARs) to murine L‐type Ca2+ current (ICa(L)) was investigated with two different approaches. The β2‐AR…”
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Role of I Kur in Controlling Action Potential Shape and Contractility in the Human Atrium: Influence of Chronic Atrial Fibrillation by Wettwer, Erich, Hála, Ottó, Christ, Torsten, Heubach, Jürgen F., Dobrev, Dobromir, Knaut, Michael, Varró, András, Ravens, Ursula

“…Background— The ultrarapid outward current I Kur is a major repolarizing current in human atrium and a potential target for treating atrial arrhythmias. The…”
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