Search Results - "Hetz, Claudio"

ER stress and the unfolded protein response in neurodegeneration by Hetz, Claudio, Saxena, Smita

“…Key Points Many neurodegenerative diseases involve the accumulation of protein aggregates Endoplasmic reticulum (ER) stress triggers activation of the unfolded…”
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Mechanisms, regulation and functions of the unfolded protein response by Hetz, Claudio, Zhang, Kezhong, Kaufman, Randal J.

“…Cellular stress induced by the abnormal accumulation of unfolded or misfolded proteins at the endoplasmic reticulum (ER) is emerging as a possible driver of…”
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Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases by Hetz, Claudio, Mollereau, Bertrand

“…Key Points Equilibrated protein homeostasis (referred to as proteostasis) requires the dynamic coordination of efficient folding of newly synthesized proteins,…”
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Emerging roles of ER stress in the etiology and pathogenesis of Alzheimer's disease by Gerakis, Yannis, Hetz, Claudio

“…Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by synaptic dysfunction and accumulation of abnormal aggregates formed by…”
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Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases by Ren, Jun, Bi, Yaguang, Sowers, James R., Hetz, Claudio, Zhang, Yingmei

“…Cardiovascular diseases (CVDs), such as ischaemic heart disease, cardiomyopathy, atherosclerosis, hypertension, stroke and heart failure, are among the leading…”
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BCL-2 family: integrating stress responses at the ER to control cell demise by Pihán, Philippe, Carreras-Sureda, Amado, Hetz, Claudio

“…In the last decade, the endoplasmic reticulum (ER) has emerged as a central organelle regulating the core mitochondrial apoptosis pathway. At the ER membrane,…”
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Calcium signaling at the endoplasmic reticulum: fine-tuning stress responses by Carreras-Sureda, Amado, Pihán, Philippe, Hetz, Claudio

“…[Display omitted] Endoplasmic reticulum (ER) calcium signaling is implicated in a myriad of coordinated cellular processes. The ER calcium content is tightly…”
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Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis by Chevet, Eric, Hetz, Claudio, Samali, Afshin

“…Stress induced by the accumulation of unfolded proteins in the endoplasmic reticulum (ER) is observed in many human diseases, including cancers. Cellular…”
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Pharmacological targeting of the unfolded protein response for disease intervention by Hetz, Claudio, Axten, Jeffrey M., Patterson, John B.

“…Accumulation of unfolded proteins at the endoplasmic reticulum (ER) is a salient attribute of many human diseases including obesity, liver disorders, cancer,…”
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ER Proteostasis Control of Neuronal Physiology and Synaptic Function by Martínez, Gabriela, Khatiwada, Sanjeev, Costa-Mattioli, Mauro, Hetz, Claudio

“…Neuronal proteostasis is maintained by the dynamic integration of different processes that regulate the synthesis, folding, quality control, and localization…”
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A chosen STING with a PERKy trail by Hazari, Younis, Hetz, Claudio

“…Cytosolic DNA sensing by the cGAS–STING pathway is critical for sustaining an innate immune defense program. A new study shows that the cGAS–STING pathway…”
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Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 1. An overview by Dufey, Estefanie, Sepúlveda, Denisse, Rojas-Rivera, Diego, Hetz, Claudio

“…Increased demand on the protein folding capacity of the endoplasmic reticulum (ER) engages an adaptive reaction known as the unfolded protein response (UPR)…”
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Endoplasmic reticulum proteostasis impairment in aging by Martínez, Gabriela, Duran‐Aniotz, Claudia, Cabral‐Miranda, Felipe, Vivar, Juan P., Hetz, Claudio

“…Summary Perturbed neuronal proteostasis is a salient feature shared by both aging and protein misfolding disorders. The proteostasis network controls the…”
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The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease by Oñate, Maritza, Catenaccio, Alejandra, Salvadores, Natalia, Saquel, Cristian, Martinez, Alexis, Moreno-Gonzalez, Ines, Gamez, Nazaret, Soto, Paulina, Soto, Claudio, Hetz, Claudio, Court, Felipe A.

“…Parkinson’s disease (PD) is the second most common neurodegenerative condition, characterized by motor impairment due to the progressive degeneration of…”
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Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat by Rodriguez, Diego, Rojas-Rivera, Diego, Hetz, Claudio

“…The assembling of distinct signaling protein complexes at the endoplasmic reticulum (ER) membrane controls several stress responses related to calcium…”
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Preventing brain aging by the artificial enforcement of the unfolded protein response: future directions by Cabral-Miranda, Felipe, Hetz, Claudio

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Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response by Dufey, Estefanie, Bravo-San Pedro, José Manuel, Eggers, Cristian, González-Quiroz, Matías, Urra, Hery, Sagredo, Alfredo I., Sepulveda, Denisse, Pihán, Philippe, Carreras-Sureda, Amado, Hazari, Younis, Sagredo, Eduardo A., Gutierrez, Daniela, Valls, Cristian, Papaioannou, Alexandra, Acosta-Alvear, Diego, Campos, Gisela, Domingos, Pedro M., Pedeux, Rémy, Chevet, Eric, Alvarez, Alejandra, Godoy, Patricio, Walter, Peter, Glavic, Alvaro, Kroemer, Guido, Hetz, Claudio

“…The molecular connections between homeostatic systems that maintain both genome integrity and proteostasis are poorly understood. Here we identify the…”
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ER stress signaling and the BCL-2 family of proteins: from adaptation to irreversible cellular damage by Hetz, Claudio A

“…Programmed cell death is essential for the development and maintenance of cellular homeostasis, and its deregulation results in a variety of pathologic…”
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Targeting PERK signaling with the small molecule GSK2606414 prevents neurodegeneration in a model of Parkinson's disease by Mercado, Gabriela, Castillo, Valentina, Soto, Paulina, López, Nélida, Axten, Jeffrey M., Sardi, Sergio P., Hoozemans, Jeroen J.M., Hetz, Claudio

“…Parkinson's disease (PD) is the second most common neurodegenerative disorder, leading to the progressive decline of motor control due to the loss of…”
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Cell death regulation by MAMs: from molecular mechanisms to therapeutic implications in cardiovascular diseases by Li, Yiran E., Sowers, James R., Hetz, Claudio, Ren, Jun

“…The endoplasmic reticulum (ER) and mitochondria are interconnected intracellular organelles with vital roles in the regulation of cell signaling and function…”
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