Search Results - "Hettige, Nuwan C"

FOXG1 Dose in Brain Development by Hettige, Nuwan C, Ernst, Carl

“…Brain development is a highly regulated process that involves the precise spatio-temporal activation of cell signaling cues. Transcription factors play an…”
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A biopsychosocial evaluation of the risk for suicide in schizophrenia by Hettige, Nuwan C., Bani-Fatemi, Ali, Sakinofsky, Isaac, De Luca, Vincenzo

“…The risk of suicide is greatly increased in individuals with schizophrenia. Previous research has identified several potential risk factors for suicidal…”
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FOXG1 targets BMP repressors and cell cycle inhibitors in human neural progenitor cells by Hettige, Nuwan C, Fleming, Peter, Semenak, Amelia, Zhang, Xin, Peng, Huashan, Hagel, Marc-Daniel, Théroux, Jean-François, Zhang, Ying, Ni, Anjie, Jefri, Malvin, Antonyan, Lilit, Alsuwaidi, Shaima, Schuppert, Andreas, Stumpf, Patrick S, Ernst, Carl

“…Abstract FOXG1 is a critical transcription factor in human brain where loss-of-function mutations cause a severe neurodevelopmental disorder, while increased…”
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Polygenic risk score prediction of antipsychotic dosage in schizophrenia by Hettige, Nuwan C, Cole, Christopher B, Khalid, Sarah, De Luca, Vincenzo

“…Abstract Objective Genetic variants have yet to be identified as reliable predictors of antipsychotic dosage. The purpose of this study is to quantify…”
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Strategies to Advance Drug Discovery in Rare Monogenic Intellectual Disability Syndromes by Hettige, Nuwan C, Manzano-Vargas, Karla, Jefri, Malvin, Ernst, Carl

“…Some intellectual disability syndromes are caused by a mutation in a single gene and have been the focus of therapeutic intervention attempts, such as Fragile…”
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Classification of suicide attempters in schizophrenia using sociocultural and clinical features: A machine learning approach by Hettige, Nuwan C, Nguyen, Thai Binh, Yuan, Chen, Rajakulendran, Thanara, Baddour, Jermeen, Bhagwat, Nikhil, Fatemi, Ali Bani, Voineskos, Aristotle, Mallar Chakravarty, M, De Luca, Vincenzo

“…Abstract Objective Suicide is a major concern for those afflicted by schizophrenia. Identifying patients at the highest risk for future suicide attempts…”
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BDNF Val66Met polymorphism and clinical response to antipsychotic treatment in schizophrenia and schizoaffective disorder patients: a meta-analysis by Huang, Eric, Hettige, Nuwan C., Zai, Gwyneth, Tomasi, Julia, Huang, Justin, Zai, Clement C., Pivac, Nela, Nikolac Perkovic, Matea, Tiwari, Arun K., Kennedy, James L.

“…Brain-derived neurotrophic factor (BDNF) plays an important role in dopaminergic and serotonergic neurotransmission by modulating dopaminergic neuron…”
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Validating a research ethnicity questionnaire using genomic markers by Hettige, Nuwan C, Bani-Fatemi, Ali, Luca, Vincenzo De

“…Population stratification is a confounding factor in genetic association studies. Self-report measures, the most common method of collecting ethnicity, may be…”
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FOXG1 dose tunes cell proliferation dynamics in human forebrain progenitor cells by Hettige, Nuwan C., Peng, Huashan, Wu, Hanrong, Zhang, Xin, Yerko, Volodymyr, Zhang, Ying, Jefri, Malvin, Soubannier, Vincent, Maussion, Gilles, Alsuwaidi, Shaima, Ni, Anjie, Rocha, Cecilia, Krishnan, Jeyashree, McCarty, Vincent, Antonyan, Lilit, Schuppert, Andreas, Turecki, Gustavo, Fon, Edward A., Durcan, Thomas M., Ernst, Carl

“…Heterozygous loss-of-function mutations in Forkhead box G1 (FOXG1), a uniquely brain-expressed gene, cause microcephaly, seizures, and severe intellectual…”
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Does a history of suicide attempt predict higher antipsychotic dosage in schizophrenia? by Hettige, Nuwan C., Kennedy, James L., De Luca, Vincenzo

“…Rationale Antipsychotic dosage is generally adjusted by physicians depending on the stability of the patient and the response to that particular drug. Our…”
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Assessing the risk for suicide in schizophrenia according to migration, ethnicity and geographical ancestry by Hettige, Nuwan C, Bani-Fatemi, Ali, Kennedy, James L, De Luca, Vincenzo

“…Suicide is a leading cause of mortality among those afflicted by schizophrenia. Previous studies demonstrated that the stressors associated with immigration…”
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Differentiation of Human Induced Pluripotent Stem Cells (iPSCs) into an Effective Model of Forebrain Neural Progenitor Cells and Mature Neurons by Bell, Scott, Hettige, Nuwan C, Silveira, Heika, Peng, Huashan, Wu, Hanrong, Jefri, Malvin, Antonyan, Lilit, Zhang, Ying, Zhang, Xin, Ernst, Carl

“…Induced Pluripotent Stem Cells (iPSCs) are pluripotent stem cells that can be generated from somatic cells, and provide a way to model the development of…”
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Candidate gene analysis of pharmacodynamic targets for antipsychotic dosage by Hettige, Nuwan C, de Moraes, Gustavo HF, Kennedy, James L, De Luca, Vincenzo

“…In order to administer antipsychotic medication with the most beneficial outcome, the appropriate drug and dose needs to be identified. Though often not…”
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Use of candidate gene markers to guide antipsychotic dosage adjustment by Hettige, Nuwan C., Zai, Clement, Hazra, Monica, Borlido, Carol, Kennedy, James L., Strauss, John, Le Foll, Bernard, Wong, Albert, Remington, Gary, De Luca, Vincenzo

“…To improve antipsychotic treatment in schizophrenia patients, many studies have investigated genetic polymorphisms associated with antipsychotic metabolizing…”
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