Search Results - "Hettich, Moritz M."

The anti-diabetic drug metformin reduces BACE1 protein level by interfering with the MID1 complex by Hettich, Moritz M, Matthes, Frank, Ryan, Devon P, Griesche, Nadine, Schröder, Susanne, Dorn, Stephanie, Krauβ, Sybille, Ehninger, Dan

“…Alzheimer's disease (AD), the most common form of dementia in the elderly, is characterized by two neuropathological hallmarks: senile plaques, which are…”
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Role of Wnt-5a in the Determination of Human Mesenchymal Stem Cells into Preadipocytes by Bilkovski, Roman, Schulte, Dominik M., Oberhauser, Frank, Gomolka, Matthias, Udelhoven, Michael, Hettich, Moritz M., Roth, Bernhard, Heidenreich, Axel, Gutschow, Christian, Krone, Wilhelm, Laudes, Matthias

“…Increasing adipocyte size as well as numbers is important in the development of obesity and type 2 diabetes, with adipocytes being generated from mesenchymal…”
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Adult-Onset Fluoxetine Treatment Does Not Improve Behavioral Impairments and May Have Adverse Effects on the Ts65Dn Mouse Model of Down Syndrome by Paesler, Katharina, Schnell, Susanne, Ryan, Devon P., Hettich, Moritz M., Heinen, Markus, Ehninger, Dan

“…Down syndrome is caused by triplication of chromosome 21 and is associated with neurocognitive phenotypes ranging from severe intellectual disability to…”
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Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex by Schweiger, Susann, Matthes, Frank, Posey, Karen, Kickstein, Eva, Weber, Stephanie, Hettich, Moritz M., Pfurtscheller, Sandra, Ehninger, Dan, Schneider, Rainer, Krauß, Sybille

“…The formation of paired helical filaments (PHF), which are composed of hyperphosphorylated Tau protein dissociating from microtubules, is one of the…”
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Limited Effects of an eIF2αS51A Allele on Neurological Impairments in the 5xFAD Mouse Model of Alzheimer’s Disease by Müller, Ralf, Garthe, Alexander, Kempermann, Gerd, Weiergräber, Marco, Ehninger, Dan, Broich, Karl, Papazoglou, Anna, Schröder, Susanne, Ryan, Devon P., Siwek, Magdalena Elisabeth, Hettich, Moritz M., Xie, Kan, Paesler, Katharina, Trog, Astrid

“…Alzheimer’s disease (AD) has been associated with increased phosphorylation of the translation initiation factor 2α (eIF2α) at serine 51. Increased…”
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Inhibition of the MID1 protein complex: a novel approach targeting APP protein synthesis by Matthes, Frank, Hettich, Moritz M., Schilling, Judith, Flores-Dominguez, Diana, Blank, Nelli, Wiglenda, Thomas, Buntru, Alexander, Wolf, Hanna, Weber, Stephanie, Vorberg, Ina, Dagane, Alina, Dittmar, Gunnar, Wanker, Erich, Ehninger, Dan, Krauss, Sybille

“…Alzheimer’s disease (AD) is characterized by two neuropathological hallmarks: senile plaques, which are composed of amyloid-β (Aβ) peptides, and…”
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The anti-diabetic drug metformin improves cognitive impairment and reduces amyloid-beta in a mouse model of Alzheimer’s disease by Matthes, Frank, Hettich, Moritz M, Ryan, Devon P, Ehninger, Dan, Krauss, Sybille

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IRS-2 branch of IGF-1 receptor signaling is essential for appropriate timing of myelination by Freude, Susanna, Leeser, Uschi, Müller, Marita, Hettich, Moritz M, Udelhoven, Michael, Schilbach, Katharina, Tobe, Kazuyuki, Kadowaki, Takashi, Köhler, Christoph, Schröder, Hannsjörg, Krone, Wilhelm, Brüning, Jens C, Schubert, Markus

“…Insulin-like growth factor (IGF)-1 increases proliferation, inhibits apoptosis and promotes differentiation of oligodendrocytes and their precursor cells,…”
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Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer’s disease by Stöhr, Oliver, Schilbach, Katharina, Moll, Lorna, Hettich, Moritz M., Freude, Susanna, Wunderlich, F. Thomas, Ernst, Marianne, Zemva, Johanna, Brüning, Jens C., Krone, Wilhelm, Udelhoven, Michael, Schubert, Markus

“…In brains from patients with Alzheimer’s disease (AD), expression of insulin receptor (IR), insulin-like growth factor-1 receptor (IGF-1R), and insulin…”
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Neuronal IGF‐1 resistance reduces Aβ accumulation and protects against premature death in a model of Alzheimer's disease by Freude, Susanna, Hettich, Moritz M., Schumann, Christina, Stöhr, Oliver, Koch, Linda, Köhler, Christoph, Udelhoven, Michael, Leeser, Uschi, Müller, Marita, Kubota, Naoto, Kadowaki, Takashi, Krone, Wilhelm, Schroder, Hannsjörg, Brüning, Jens C., Schubert, Markus

“…ABSTRACT Alzheimer's disease (AD) is characterized by progressive neurodegeneration leading to loss of cognitive abilities and ultimately to death. Postmortem…”
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P4‐173: The anti‐diabetic drug metformin improves cognitive impairment and reduces amyloid‐beta in a mouse model of Alzheimer's disease by Matthes, Frank, Hettich, Moritz M., Ryan, Devon P., Ehninger, Dan, Krauss, Sybille

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Insulin receptor signaling mediates APP processing and [beta]-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer's disease by Stöhr, Oliver, Schilbach, Katharina, Moll, Lorna, Hettich, Moritz M

“…In brains from patients with Alzheimer's disease (AD), expression of insulin receptor (IR), insulin-like growth factor-1 receptor (IGF-1R), and insulin…”
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Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease by Freude, Susanna, Hettich, Moritz M, Schumann, Christina, Stöhr, Oliver, Koch, Linda, Köhler, Christoph, Udelhoven, Michael, Leeser, Uschi, Müller, Marita, Kubota, Naoto, Kadowaki, Takashi, Krone, Wilhelm, Schröder, Hannsjörg, Brüning, Jens C, Schubert, Markus

“…Alzheimer's disease (AD) is characterized by progressive neurodegeneration leading to loss of cognitive abilities and ultimately to death. Postmortem…”
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