Search Results - "Hett, Erik C."

Microenvironment mapping via Dexter energy transfer on immune cells by Geri, Jacob B, Oakley, James V, Reyes-Robles, Tamara, Wang, Tao, McCarver, Stefan J, White, Cory H, Rodriguez-Rivera, Frances P, Parker, Jr, Dann L, Hett, Erik C, Fadeyi, Olugbeminiyi O, Oslund, Rob C, MacMillan, David W C

“…Many disease pathologies can be understood through the elucidation of localized biomolecular networks, or microenvironments. To this end, enzymatic proximity…”
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Bacterial Growth and Cell Division: a Mycobacterial Perspective by HETT, Erik C, RUBIN, Eric J

“…Article Usage Stats Services MMBR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors by Lanning, Bryan R, Whitby, Landon R, Dix, Melissa M, Douhan, John, Gilbert, Adam M, Hett, Erik C, Johnson, Theodore O, Joslyn, Chris, Kath, John C, Niessen, Sherry, Roberts, Lee R, Schnute, Mark E, Wang, Chu, Hulce, Jonathan J, Wei, Baoxian, Whiteley, Laurence O, Hayward, Matthew M, Cravatt, Benjamin F

“…ABPP combined with quantitative MS enabled identification of specific on- and off-targets of covalent kinase inhibitors. Modifications to inhibitors that alter…”
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Detection of cell–cell interactions via photocatalytic cell tagging by Oslund, Rob C., Reyes-Robles, Tamara, White, Cory H., Tomlinson, Jake H., Crotty, Kelly A., Bowman, Edward P., Chang, Dan, Peterson, Vanessa M., Li, Lixia, Frutos, Silvia, Vila-Perelló, Miquel, Vlerick, David, Cromie, Karen, Perlman, David H., Ingale, Sampat, Hara, Samantha D. O’, Roberts, Lee R., Piizzi, Grazia, Hett, Erik C., Hazuda, Daria J., Fadeyi, Olugbeminiyi O.

“…The growing appreciation of immune cell–cell interactions within disease environments has led to extensive efforts to develop immunotherapies. However,…”
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Covalent Enzyme Inhibition through Fluorosulfate Modification of a Noncatalytic Serine Residue by Fadeyi, Olugbeminiyi O, Hoth, Lise R, Choi, Chulho, Feng, Xidong, Gopalsamy, Ariamala, Hett, Erik C, Kyne, Robert E, Robinson, Ralph P, Jones, Lyn H

“…Irreversible enzyme inhibitors and covalent chemical biology probes often utilize the reaction of a protein cysteine residue with an appropriately positioned…”
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Rational Targeting of Active-Site Tyrosine Residues Using Sulfonyl Fluoride Probes by Hett, Erik C, Xu, Hua, Geoghegan, Kieran F, Gopalsamy, Ariamala, Kyne, Robert E, Menard, Carol A, Narayanan, Arjun, Parikh, Mihir D, Liu, Shenping, Roberts, Lee, Robinson, Ralph P, Tones, Michael A, Jones, Lyn H

“…This work describes the first rational targeting of tyrosine residues in a protein binding site by small-molecule covalent probes. Specific tyrosine residues…”
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Interaction and modulation of two antagonistic cell wall enzymes of mycobacteria by Hett, Erik C, Chao, Michael C, Rubin, Eric J

“…Bacterial cell growth and division require coordinated cell wall hydrolysis and synthesis, allowing for the removal and expansion of cell wall material…”
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A mycobacterial enzyme essential for cell division synergizes with resuscitation-promoting factor by Hett, Erik C, Chao, Michael C, Deng, Lynn L, Rubin, Eric J

“…The final stage of bacterial cell division requires the activity of one or more enzymes capable of degrading the layers of peptidoglycan connecting two…”
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Cellular thermal shift and clickable chemical probe assays for the determination of drug-target engagement in live cells by Xu, Hua, Gopalsamy, Ariamala, Hett, Erik C, Salter, Shores, Aulabaugh, Ann, Kyne, Robert E, Pierce, Betsy, Jones, Lyn H

“…Proof of drug-target engagement in physiologically-relevant contexts is a key pillar of successful therapeutic target validation. We developed two orthogonal…”
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Mycobacterium tuberculosis Rv2224c modulates innate immune responses by Rengarajan, Jyothi, Murphy, Elissa, Park, Arnold, Krone, Cassandra L, Hett, Erik C, Bloom, Barry R, Glimcher, Laurie H, Rubin, Eric J

“…Tuberculosis remains a major global health problem that kills up to 2 million people annually. Central to the success of Mycobacterium tuberculosis (Mtb) as a…”
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A high-throughput microfluidic mechanoporation platform to enable intracellular delivery of cyclic peptides in cell-based assays by Kasper, Stephen H, Otten, Stephanie, Squadroni, Brian, Orr-Terry, Cionna, Kuang, Yi, Mussallem, Lily, Ge, Lan, Yan, Lin, Kannan, Srinivasaraghavan, Verma, Chandra S, Brown, Christopher J, Johannes, Charles W, Lane, David P, Chandramohan, Arun, Partridge, Anthony W, Roberts, Lee R, Josien, Hubert, Therien, Alex G, Hett, Erik C, Howell, Bonnie J, Peier, Andrea, Ai, Xi, Cassaday, Jason

“…Cyclic peptides are poised to target historically difficult to drug intracellular protein-protein interactions, however, their general cell impermeability…”
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CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells by Slater, Louise H., Hett, Erik C., Clatworthy, Anne E., Mark, Kevin G., Hung, Deborah T.

“…Bacterial toxins have evolved successful strategies for coopting host proteins to access the cytosol of host cells. Anthrax lethal factor (LF) enters the…”
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A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS by Xu, Hua, Hett, Erik C, Gopalsamy, Ariamala, Parikh, Mihir D, Geoghegan, Kieran F, Kyne, Jr, Robert E, Menard, Carol A, Narayanan, Arjun, Robinson, Ralph P, Johnson, Douglas S, Tones, Michael A, Jones, Lyn H

“…Despite its diverse applications, such as identification of the protein binding partners of small molecules and investigation of intracellular drug-target…”
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Know your target, know your molecule by Bunnage, Mark E, Gilbert, Adam M, Jones, Lyn H, Hett, Erik C

“…The pharmaceutical industry continues to experience significant attrition of drug candidates during phase 2 proof-of-concept clinical studies. We describe some…”
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Colorectal cancer-associated anaerobic bacteria proliferate in tumor spheroids and alter the microenvironment by Kasper, Stephen H., Morell-Perez, Carolina, Wyche, Thomas P., Sana, Theodore R., Lieberman, Linda A., Hett, Erik C.

“…Recent reports show that colorectal tumors contain microbiota that are distinct from those that reside in a ‘normal’ colon environment, and that these…”
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Understanding and applying tyrosine biochemical diversity by Jones, Lyn H, Narayanan, Arjun, Hett, Erik C

“…This review highlights some of the recent advances made in our understanding of the diversity of tyrosine biochemistry and shows how this has inspired novel…”
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Follicular T cells optimize the germinal center response to SARS-CoV-2 protein vaccination in mice by Cavazzoni, Cecilia B., Hanson, Benjamin L., Podestà, Manuel A., Bechu, Elsa D., Clement, Rachel L., Zhang, Hengcheng, Daccache, Joe, Reyes-Robles, Tamara, Hett, Erik C., Vora, Kalpit A., Fadeyi, Olugbeminiyi O., Oslund, Rob C., Hazuda, Daria J., Sage, Peter T.

“…Follicular helper T (Tfh) cells promote, whereas follicular regulatory T (Tfr) cells restrain, germinal center (GC) reactions. However, the precise roles of…”
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Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis by Hett, Erik C, Slater, Louise H, Mark, Kevin G, Kawate, Tomohiko, Monks, Brian G, Stutz, Andrea, Latz, Eicke, Hung, Deborah T

“…A small molecule that protects macrophages from lethal toxin–induced pyroptosis reveals a kinase-independent role for protein kinase R in caspase-1 activation…”
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Design of a Multiuse Photoreactor To Enable Visible‐Light Photocatalytic Chemical Transformations and Labeling in Live Cells by Bissonnette, Noah B., Ryu, Keun Ah, Reyes‐Robles, Tamara, Wilhelm, Sharon, Tomlinson, Jake H., Crotty, Kelly A., Hett, Erik C., Roberts, Lee R., Hazuda, Daria J., Jared Willis, M., Oslund, Rob C., Fadeyi, Olugbeminiyi O.

“…Despite the growing use of visible‐light photochemistry in both chemistry and biology, no general low‐heat photoreactor for use across these different…”
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CDK12-mediated transcriptional regulation of noncanonical NF-κB components is essential for signaling by Henry, Kate L, Kellner, Debra, Bajrami, Bekim, Anderson, John E, Beyna, Mercedes, Bhisetti, Govinda, Cameron, Tom, Capacci, Andrew G, Bertolotti-Ciarlet, Andrea, Feng, Jun, Gao, Benbo, Hopkins, Brian, Jenkins, Tracy, Li, Kejie, May-Dracka, Tricia, Murugan, Paramasivam, Wei, Ru, Zeng, Weike, Allaire, Norm, Buckler, Alan, Loh, Christine, Juhasz, Peter, Lucas, Brian, Ennis, Katelin A, Vollman, Elisabeth, Cahir-McFarland, Ellen, Hett, Erik C, Ols, Michelle L

“…Members of the family of nuclear factor κB (NF-κB) transcription factors are critical for multiple cellular processes, including regulating innate and adaptive…”
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