Search Results - "Heston, Warren"

A Perspective on the Evolving Story of PSMA Biology, PSMA-Based Imaging, and Endoradiotherapeutic Strategies by O'Keefe, Denise S, Bacich, Dean J, Huang, Steve S, Heston, Warren D W

“…In this review, we cover the evolution of knowledge on the biology of prostate-specific membrane antigen (PSMA) and its translation to therapy. The usual key…”
Get full text

Intriguing information from recent letter and article regarding unwanted targeting of salivary glands by PSMA ligands by Huang, Steve S., DiFilippo, Frank, Lindner, Daniel, Heston, Warren D. W.

Get full text

GCP III is not the “off-target” for urea-based PSMA ligands by Lee, Zhenghong, Heston, Warren D., Wang, Xinning, Basilion, James P.

Get full text

PARP inhibition sensitizes to low dose-rate radiation TMPRSS2-ERG fusion gene-expressing and PTEN-deficient prostate cancer cells by Chatterjee, Payel, Choudhary, Gaurav S, Sharma, Arishya, Singh, Kamini, Heston, Warren D, Ciezki, Jay, Klein, Eric A, Almasan, Alexandru

“…Exposure to genotoxic agents, such as irradiation produces DNA damage, the toxicity of which is augmented when the DNA repair is impaired. Poly (ADP-ribose)…”
Get full text

Commentary RE: Upregulation of PSMA Following Androgen Deprivation Therapy by Heston, Warren D.W.

Get full text

Development of targeted near-infrared imaging agents for prostate cancer by Wang, Xinning, Huang, Steve S, Heston, Warren D W, Guo, Hong, Wang, Bing-Cheng, Basilion, James P

“…Prostate cancer is the most common noncutaneous malignancy affecting men in North America. Radical prostatectomy remains a definitive treatment for prostate…”
Get full text

Tumor target prostate specific membrane antigen (PSMA) and its regulation in prostate cancer by Ghosh, Arundhati, Heston, Warren D.W.

“…Prostate specific membrane antigen (PSMA), is a unique membrane bound glycoprotein, which is overexpressed manifold on prostate cancer as well as…”
Get full text

Targeted, Activatable, In Vivo Fluorescence Imaging of Prostate-Specific Membrane Antigen (PSMA) Positive Tumors Using the Quenched Humanized J591 Antibody–Indocyanine Green (ICG) Conjugate by Nakajima, Takahito, Mitsunaga, Makoto, Bander, Neil H, Heston, Warren D, Choyke, Peter L, Kobayashi, Hisataka

“…In patients with prostate cancer, a positive surgical margin is associated with an increased risk of cancer recurrence and poorer outcome, yet margin status…”
Get full text

In vitro and in vivo responses of advanced prostate tumors to PSMA ADC, an auristatin-conjugated antibody to prostate-specific membrane antigen by Wang, Xinning, Ma, Dangshe, Olson, William C, Heston, Warren D W

“…Prostate-specific membrane antigen (PSMA) is a membrane protein that is overexpressed manifold in prostate cancer and provides an attractive target for…”
Get full text

Role of TMPRSS2-ERG gene fusion in negative regulation of PSMA expression by Yin, Lihong, Rao, Pravin, Elson, Paul, Wang, Jianghua, Ittmann, Michael, Heston, Warren D W

“…Prostate specific membrane antigen (PSMA) is overexpressed in prostatic adenocarcinoma (CaP), and its expression is negatively regulated by androgen…”
Get full text

Novel role of prostate-specific membrane antigen in suppressing prostate cancer invasiveness by GHOSH, Arundhati, XINNING WANG, KLEIN, Eric, HESTON, Warren D. W

“…Prostate-specific membrane antigen (PSMA), a type II transmembrane glycoprotein, is overexpressed in prostate cancer. PSMA is a unique cell surface marker,…”
Get full text

Autophagic flux determines cell death and survival in response to Apo2L/TRAIL (dulanermin) by Singh, Kamini, Sharma, Arishya, Mir, Maria C, Drazba, Judith A, Heston, Warren D, Magi-Galluzzi, Cristina, Hansel, Donna, Rubin, Brian P, Klein, Eric A, Almasan, Alexandru

“…Macroautophagy is a catabolic process that can mediate cell death or survival. Apo2 ligand (Apo2L)/tumor necrosis factor-related apoptosis-inducing ligand…”
Get full text

Resveratrol regulates the PTEN/AKT pathway through androgen receptor-dependent and -independent mechanisms in prostate cancer cell lines by Wang, Yu, Romigh, Todd, He, Xin, Orloff, Mohammed S., Silverman, Robert H., Heston, Warren D., Eng, Charis

“…The tumor suppressor gene PTEN (phosphatase and tensin homolog deleted on chromosome 10) and the androgen receptor (AR) play important roles in tumor…”
Get full text

Should Low Molecular Weight PSMA Targeted Ligands Get Bigger and Use Albumin Ligands for PSMA Targeting? by Huang, Steve S, Heston, Warren D W

“…Prostate Specific Membrane Antigen (PSMA) is strongly expressed in prostate cancer. Recently a number of low-molecular-weight inhibitors have demonstrated…”
Get full text

Improving the biodistribution of PSMA-targeting tracers with a highly negatively charged linker by Huang, Steve S., Wang, Xinning, Zhang, Yuqing, Doke, Aniruddha, DiFilippo, Frank P., Heston, Warren D.

“…BACKGROUND Prostate specific membrane antigen (PSMA) is overexpressed in prostate cancer and in tumor vasculature. Small molecule based inhibitors of PSMA have…”
Get full text

A novel PSMA-targeting tracer with highly negatively charged linker demonstrates decreased salivary gland uptake in mice compared to [68Ga]Ga-PSMA-11 by Huang, Steve S., DiFilippo, Frank P., Lindner, Daniel J., Heston, Warren D.

“…Background The current generation of radiolabeled PSMA-targeting therapeutic agents is limited by prominent salivary gland binding, which results in…”
Get full text

The TMPRSS2-ERG Gene Fusion Blocks XRCC4-Mediated Nonhomologous End-Joining Repair and Radiosensitizes Prostate Cancer Cells to PARP Inhibition by Chatterjee, Payel, Choudhary, Gaurav S, Alswillah, Turkeyah, Xiong, Xiahui, Heston, Warren D, Magi-Galluzzi, Cristina, Zhang, Junran, Klein, Eric A, Almasan, Alexandru

“…Exposure to genotoxic agents, such as ionizing radiation (IR), produces DNA damage, leading to DNA double-strand breaks (DSB); IR toxicity is augmented when…”
Get full text

Moderate expression of prostate-specific membrane antigen, a tissue differentiation antigen and folate hydrolase, facilitates prostate carcinogenesis by Yao, Veronica, Parwani, Anil, Maier, Christoph, Heston, Warren DeWayne, Bacich, Dean John

“…Increased expression of PSMA, a differentiation antigen with folate hydrolase activity, is an independent marker of prostate cancer progression. Mice…”
Get full text

A Novel Alphavirus Vaccine Encoding Prostate-Specific Membrane Antigen Elicits Potent Cellular and Humoral Immune Responses by DURSO, Robert J, ANDJELIC, Sofija, HESTON, Warren D. W, MADDON, Paul J, OLSON, William C, GARDNER, Jason P, MARGITICH, Dennis J, DONOVAN, Gerald P, ARRIGALE, Robert R, XINNING WANG, MAUGHAN, Maureen F, TALARICO, Todd L, OLMSTED, Robert A

“…Purpose: Prostate-specific membrane antigen (PSMA) is an attractive target for active immunotherapy. Alphavirus vaccines have shown promise in eliciting…”
Get full text

Selenoprotein P neutralizes lipopolysaccharide and participates in hepatic cell endoplasmic reticulum stress response by Zhao, Yongzhong, Banerjee, Shuvojit, Huang, Ping, Wang, Xinning, Gladson, Candece L., Heston, Warren D., Foster, Charles B.

“…Low serum selenium or selenoprotein P (SePP) levels have been repetitively observed in severe sepsis. The role of SePP in sepsis is incompletely characterized…”
Get full text