Search Results - "Hesselink, Matthijs"

Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus by Hesselink, Matthijs K. C., Schrauwen-Hinderling, Vera, Schrauwen, Patrick

“…Key Points Type 2 diabetes mellitus (T2DM) is associated with reduced mitochondrial function in the skeletal muscle and metabolic inflexibility Healthy…”
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Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans by Timmers, Silvie, Konings, Ellen, Bilet, Lena, Houtkooper, Riekelt H., van de Weijer, Tineke, Goossens, Gijs H., Hoeks, Joris, van der Krieken, Sophie, Ryu, Dongryeol, Kersten, Sander, Moonen-Kornips, Esther, Hesselink, Matthijs K.C., Kunz, Iris, Schrauwen-Hinderling, Vera B., Blaak, Ellen E., Auwerx, Johan, Schrauwen, Patrick

“…Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal…”
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Exercising your fat (metabolism) into shape: a muscle-centred view by Gemmink, Anne, Schrauwen, Patrick, Hesselink, Matthijs K. C.

“…Fatty acids are an important energy source during exercise. Training status and substrate availability are determinants of the relative and absolute…”
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Breaking sitting with light activities vs structured exercise: a randomised crossover study demonstrating benefits for glycaemic control and insulin sensitivity in type 2 diabetes by Duvivier, Bernard M. F. M., Schaper, Nicolaas C., Hesselink, Matthijs K. C., van Kan, Linh, Stienen, Nathalie, Winkens, Bjorn, Koster, Annemarie, Savelberg, Hans H. C. M.

“…Aims/hypothesis We aimed to examine the effects of breaking sitting with standing and light-intensity walking vs an energy-matched bout of structured exercise…”
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Elevated Plasma Branched-Chain Amino Acid Levels Correlate With Type 2 Diabetes–Related Metabolic Disturbances by Vanweert, Froukje, de Ligt, Marlies, Hoeks, Joris, Hesselink, Matthijs K C, Schrauwen, Patrick, Phielix, Esther

“…Abstract Context Patients with type 2 diabetes mellitus (T2DM) have elevated plasma branched-chain amino acid (BCAA) levels. The underlying cause, however, is…”
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Effects of exercise training on intrahepatic lipid content in humans by Brouwers, Bram, Hesselink, Matthijs K. C., Schrauwen, Patrick, Schrauwen-Hinderling, Vera B.

“…Non-alcoholic fatty liver (NAFL) is the most common liver disorder in western society. Various factors may play a role in determining hepatic fat content, such…”
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Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle by Wefers, Jakob, van Moorsel, Dirk, Hansen, Jan, Connell, Niels J., Havekes, Bas, Hoeks, Joris, van Marken Lichtenbelt, Wouter D., Duez, Hélène, Phielix, Esther, Kalsbeek, Andries, Boekschoten, Mark V., Hooiveld, Guido J., Hesselink, Matthijs K. C., Kersten, Sander, Staels, Bart, Scheer, Frank A. J. L., Schrauwen, Patrick

“…Circadian misalignment, such as in shift work, has been associated with obesity and type 2 diabetes. However, direct effects of circadian misalignment on…”
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Therapeutic potential of resveratrol in obesity and type 2 diabetes: new avenues for health benefits? by Timmers, Silvie, Hesselink, Matthijs K.C., Schrauwen, Patrick

“…The number of people suffering from metabolic disorders is dramatically increasing worldwide. The need for new therapeutic strategies to combat this growing…”
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Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus by Hanssen, Mark J W, Hoeks, Joris, Brans, Boudewijn, van der Lans, Anouk A J J, Schaart, Gert, van den Driessche, José J, Jörgensen, Johanna A, Boekschoten, Mark V, Hesselink, Matthijs K C, Havekes, Bas, Kersten, Sander, Mottaghy, Felix M, van Marken Lichtenbelt, Wouter D, Schrauwen, Patrick

“…A small clinical trial shows that short-term cold acclimation to moderately-cold temperature improves the glucose homeostasis of individuals with type 2…”
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Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy by Woldt, Estelle, Sebti, Yasmine, Solt, Laura A, Duhem, Christian, Lancel, Steve, Eeckhoute, Jérôme, Hesselink, Matthijs K C, Paquet, Charlotte, Delhaye, Stéphane, Shin, Youseung, Kamenecka, Theodore M, Schaart, Gert, Lefebvre, Philippe, Nevière, Rémi, Burris, Thomas P, Schrauwen, Patrick, Staels, Bart, Duez, Hélène

“…Bart Staels and his colleagues show that the transcription factor Rev-erb-α is highly expressed in oxidative muscle and, via loss- and gain-of-function…”
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Restoration of Muscle Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes by Exercise Training Is Paralleled by Increased Myocellular Fat Storage and Improved Insulin Sensitivity by MEEX, Ruth C. R, SCHRAUWEN-HINDERLING, Vera B, MOONEN-KORNIPS, Esther, SCHAART, Gert, MENSINK, Marco, PHIELIX, Esther, VAN DE WEIJER, Tineke, SELS, Jean-Pierre, SCHRAUWEN, Patrick, HESSELINK, Matthijs K. C

“…Mitochondrial dysfunction and fat accumulation in skeletal muscle (increased intramyocellular lipid [IMCL]) have been linked to development of type 2 diabetes…”
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Human skeletal muscle mitochondrial dynamics in relation to oxidative capacity and insulin sensitivity by Houzelle, Alexandre, Jörgensen, Johanna A., Schaart, Gert, Daemen, Sabine, van Polanen, Nynke, Fealy, Ciarán E., Hesselink, Matthijs K. C., Schrauwen, Patrick, Hoeks, Joris

“…Aims/hypothesis Mitochondria operate in networks, adapting to external stresses and changes in cellular metabolic demand and are subject to various quality…”
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Lower Intrinsic ADP-Stimulated Mitochondrial Respiration Underlies In Vivo Mitochondrial Dysfunction in Muscle of Male Type 2 Diabetic Patients by PHIELIX, Esther, SCHRAUWEN-HINDERLING, Vera B, SCHRAUWEN, Patrick, MENSINK, Marco, LENAERS, Ellen, MEEX, Ruth, HOEKS, Joris, ELINE KOOI, Marianne, MOONEN-KORNIPS, Esther, SELS, Jean-Pierre, HESSELINK, Matthijs K. C

“…Lower Intrinsic ADP-Stimulated Mitochondrial Respiration Underlies In Vivo Mitochondrial Dysfunction in Muscle of Male Type 2 Diabetic Patients Esther Phielix…”
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Resveratrol as Add-on Therapy in Subjects With Well-Controlled Type 2 Diabetes: A Randomized Controlled Trial by Timmers, Silvie, de Ligt, Marlies, Phielix, Esther, van de Weijer, Tineke, Hansen, Jan, Moonen-Kornips, Esther, Schaart, Gert, Kunz, Iris, Hesselink, Matthijs K C, Schrauwen-Hinderling, Vera B, Schrauwen, Patrick

“…To determine whether resveratrol supplementation can improve insulin sensitivity and promote overall metabolic health on top of standard diabetes care…”
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A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes by Vanweert, Froukje, Neinast, Michael, Tapia, Edmundo Erazo, van de Weijer, Tineke, Hoeks, Joris, Schrauwen-Hinderling, Vera B., Blair, Megan C., Bornstein, Marc R., Hesselink, Matthijs K. C., Schrauwen, Patrick, Arany, Zoltan, Phielix, Esther

“…Elevations in plasma branched-chain amino acid (BCAA) levels associate with insulin resistance and type 2 diabetes (T2D). Pre-clinical models suggest that…”
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Perilipin 2 Improves Insulin Sensitivity in Skeletal Muscle Despite Elevated Intramuscular Lipid Levels by BOSMA, Madeleen, HESSELINK, Matthijs K. C, KERSTEN, Sander, SCHRAUWEN, Patrick, SPARKS, Lauren M, TIMMERS, Silvie, FERRAZ, Maria Joao, MATTIJSSEN, Frits, BEURDEN, Denis Van, SCHAART, Gert, DE BAETS, Marc H, VERHEYEN, Fons K

“…Type 2 diabetes is characterized by excessive lipid storage in skeletal muscle. Excessive intramyocellular lipid (IMCL) storage exceeds intracellular needs and…”
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Skeletal muscle mitochondrial network dynamics in metabolic disorders and aging by Fealy, Ciarán E., Grevendonk, Lotte, Hoeks, Joris, Hesselink, Matthijs K.C.

“…With global demographics trending towards an aging population, the numbers of individuals with an age-associated loss of independence is increasing. A key…”
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Timing of physical activity in relation to liver fat content and insulin resistance by van der Velde, Jeroen H. P. M., Boone, Sebastiaan C., Winters-van Eekelen, Esther, Hesselink, Matthijs K. C., Schrauwen-Hinderling, Vera B., Schrauwen, Patrick, Lamb, Hildo J., Rosendaal, Frits R., de Mutsert, Renée

“…Aims/hypothesis We hypothesised that the insulin-sensitising effect of physical activity depends on the timing of the activity. Here, we examined…”
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Nine Months of Combined Training Improves Ex Vivo Skeletal Muscle Metabolism in Individuals With Type 2 Diabetes by Sparks, Lauren M, Johannsen, Neil M, Church, Timothy S, Earnest, Conrad P, Moonen-Kornips, Esther, Moro, Cedric, Hesselink, Matthijs K. C, Smith, Steven R, Schrauwen, Patrick

“…Context: Type 2 diabetes (T2D) has features of disordered lipid and glucose metabolism, due in part to reduced mitochondrial content. Objective: Our objective…”
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Effects of the SGLT2 Inhibitor Dapagliflozin on Energy Metabolism in Patients With Type 2 Diabetes: A Randomized, Double-Blind Crossover Trial by Op den Kamp, Yvo J M, de Ligt, Marlies, Dautzenberg, Bas, Kornips, Esther, Esterline, Russell, Hesselink, Matthijs K C, Hoeks, Joris, Schrauwen-Hinderling, Vera B, Havekes, Bas, Oscarsson, Jan, Phielix, Esther, Schrauwen, Patrick

“…SGTL2 inhibitors increase urinary glucose excretion and have beneficial effects on cardiovascular and renal outcomes. The underlying mechanism may involve…”
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