Search Results - "Hesseling, A. C."

Interferon-gamma release assays and childhood tuberculosis: systematic review and meta-analysis [Review article] by MANDALAKAS, A. M, DETJEN, A. K, HESSELING, A. C, BENEDETTI, A, MENZIES, D

“…BACKGROUND: Children infected with Mycobacterium tuberculosis have significant risk of developing tuberculosis (TB) and can therefore benefit from preventive…”
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Fungal diversity in the gut microbiome of young South African children by Nel Van Zyl, K, Whitelaw, A C, Hesseling, A C, Seddon, J A, Demers, A-M, Newton-Foot, M

“…The fungal microbiome, or mycobiome, is a poorly described component of the gut ecosystem and little is known about its structure and development in children…”
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High Incidence of Tuberculosis among HIV-Infected Infants: Evidence from a South African Population-Based Study Highlights the Need for Improved Tuberculosis Control Strategies by Hesseling, A. C., Cotton, M. F., Jennings, T., Whitelaw, A., Johnson, L. F., Eley, B., Roux, P., Godfrey-Faussett, P., Schaaf, H. S.

“…Background. There are limited population-based estimates of tuberculosis incidence among human immunodeficiency virus (HIV)—infected and HIV-uninfected infants…”
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Pharmacokinetics of Rifampin, Isoniazid, Pyrazinamide, and Ethambutol in Infants Dosed According to Revised WHO-Recommended Treatment Guidelines by Bekker, A, Schaaf, H S, Draper, H R, van der Laan, L, Murray, S, Wiesner, L, Donald, P R, McIlleron, H M, Hesseling, A C

“…There are limited pharmacokinetic data for use of the first-line antituberculosis drugs during infancy (<12 months of age), when drug disposition may differ…”
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Pharmacokinetics of Isoniazid, Rifampin, and Pyrazinamide in Children Younger than Two Years of Age with Tuberculosis: Evidence for Implementation of Revised World Health Organization Recommendations by THEE, S, SEDDON, J. A, DONALD, P. R, SEIFART, H. I, WERELY, C. J, HESSELING, A. C, ROSENKRANZ, B, ROLL, S, MAGDORF, K, SCHAAF, H. S

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High burden of viral respiratory co-infections in a cohort of children with suspected pulmonary tuberculosis by van der Zalm, M M, Walters, E, Claassen, M, Palmer, M, Seddon, J A, Demers, A M, Shaw, M L, McCollum, E D, van Zyl, G U, Hesseling, A C

“…The presentation of pulmonary tuberculosis (PTB) in young children is often clinically indistinguishable from other common respiratory illnesses, which are…”
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The natural history of childhood intra-thoracic tuberculosis: a critical review of literature from the pre-chemotherapy era [State of the Art] by MARAIS, B. J, GIE, R. P, SCHAAF, H. S, HESSELING, A. C, OBIHARA, C. C, STARKE, J. J, ENARSON, T. D. A, DONALD, P. R, BEYERS, N

“…The pre-chemotherapy literature documented the natural history of tuberculosis in childhood. These disease descriptions remain invaluable for guiding public…”
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Bacille Calmette-Guérin Vaccine—Induced Disease in HIV-Infected and HIV-Uninfected Children by Hesseling, A. C., Rabie, H., Marais, B. J., Manders, M., Lips, M., Schaaf, H. S., Gie, R. P., Cotton, M. F., van Helden, P. D., Warren, R. M., Beyers, N.

“…Background. Bacille Calmette-Guérin (BCG)—a live, attenuated vaccine—is routinely given to neonates in settings where tuberculosis is endemic, irrespective of…”
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Disseminated bacille Calmette―Guérin disease in HIV-infected South African infants by HESSELING, A. C, JOHNSON, L. F, BEYERS, N, GODFREY-FAUSSETT, P, JASPAN, H, COTTON, M. F, WHITELAW, A, SCHAAF, H. S, FINE, Pem, ELEY, B. S, MARAIS, B. J, NUTTALL, J

“…To determine the population-based incidence of disseminated bacille Calmette-Guérin (BCG) disease in HIV-infected infants (aged <or= 1 year) in a setting with…”
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Well-quantified tuberculosis exposure is a reliable surrogate measure of tuberculosis infection by Mandalakas, A. M., Kirchner, H. L., Lombard, C., Walzl, G., Grewal, H. M. S., Gie, R. P., Hesseling, A. C.

“…SETTING: Cape Town, South Africa.OBJECTIVE: To develop a standardized, reliable measure of household tuberculosis (TB) exposure that considers child-specific…”
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Pharmacokinetics of Ofloxacin and Levofloxacin for Prevention and Treatment of Multidrug-Resistant Tuberculosis in Children by THEE, S, GARCIA-PRATS, A. J, MCILLERON, H. M, WIESNER, L, CASTEL, S, NORMAN, J, DRAPER, H. R, VAN DER MERWE, P. L, HESSELING, A. C, SCHAAF, H. S

“…Limited data on fluoroquinolone pharmacokinetics and cardiac effects in children exist. Among 22 children receiving drug-resistant tuberculosis prophylaxis or…”
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Ambulatory Gastric Lavages Provide Better Yields of Mycobacterium tuberculosis Than Induced Sputum in Children With Intrathoracic Tuberculosis by MUKHERJEE, Aparna, SINGH, Sarman, LODHA, Rakesh, SINGH, Varinder, HESSELING, A. C, GREWAL, Harleen M. S, KABRA, Sushil K

“…To compare mycobacterial yield by induced sputum (IS) and gastric lavage (GL), performed on an ambulatory basis in children with probable intrathoracic…”
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The burden of childhood tuberculosis and the accuracy of community-based surveillance data by MARAIS, B. J, HESSELING, A. C, GIE, R. P, SCHAAF, H. S, BEYERS, N

“…BACKGROUND: Inadequate surveillance and diagnostic difficulties compromise the quality of epidemiological data on childhood tuberculosis (TB).OBJECTIVE: To…”
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Highly discordant T cell responses in individuals with recent exposure to household tuberculosis by Hesseling, A C, Mandalakas, A M, Kirchner, H L, Chegou, N N, Marais, B J, Stanley, K, Zhu, X, Black, G, Beyers, N, Walzl, G

“…There are limited data comparing interferon-gamma release assays (IGRAs) for the detection of Mycobacterium tuberculosis infection in highly endemic settings…”
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Pharmacokinetics of Isoniazid in Low-Birth-Weight and Premature Infants by BEKKER, A, SCHAAF, H. S, SEIFART, H. I, DRAPER, H. R, WERELY, C. J, COTTON, M. F, HESSELING, A. C

“…Isoniazid (INH) is recommended for use as posttuberculosis exposure preventive therapy in children. However, no pharmacokinetic data are available for INH…”
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Pharmacokinetics of Ethionamide in Children by THEE, S, SEIFART, H. I, ROSENKRANZ, B, HESSELING, A. C, MAGDORF, K, DONALD, P. R, SCHAAF, H. S

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The evolving epidemic of drug-resistant tuberculosis among children in Cape Town, South Africa by Seddon, J. A., Hesseling, A. C., Marais, B. J., Jordaan, A., Victor, T., Schaaf, H. S.

“…SETTING: Tygerberg Children's Hospital, Cape Town, South Africa.OBJECTIVE: To determine the prevalence and trend of drug resistance and human immunodeficiency…”
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Linezolid-containing regimens for the treatment of drug-resistant tuberculosis in South African children by Rose, P. C., Hallbauer, U. M., Seddon, J. A., Hesseling, A. C., Schaaf, H. S.

“…BACKGROUND: Treatment options for drug-resistant tuberculosis (DR-TB) are limited. Linezolid has been successfully used to treat DR-TB in adults, but there are…”
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High level of discordant IGRA results in HIV-infected adults and children by MANDALAKAS, A. M, HESSELING, A. C, CHEGOU, N. N, KIRCHNER, H. L, ZHU, X, MARAIS, B. J, BLACK, G. F, BEYERS, N, WALZL, G

“…SETTING: Tygerberg district, Western Cape Province, South Africa.OBJECTIVE: To measure the agreement of two interferon-gamma release assays (IGRAs) and the…”
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The spectrum of disease in children treated for tuberculosis in a highly endemic area [Unresolved Issues] by MARAIS, B. J, GIE, R. P, SCHAAF, H. S, HESSELING, A. C, ENARSON, D. A, BEYERS, N

“…BACKGROUND: Children contribute a substantial proportion of the global tuberculosis (TB) caseload, particularly in endemic areas, where little is known about…”
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