Search Results - "Hesseling"

Pharmacokinetics, optimal dosing, and safety of linezolid in children with multidrug-resistant tuberculosis: Combined data from two prospective observational studies by Garcia-Prats, Anthony J, Schaaf, H Simon, Draper, Heather R, Garcia-Cremades, Maria, Winckler, Jana, Wiesner, Lubbe, Hesseling, Anneke C, Savic, Rada M

“…Linezolid is increasingly important for multidrug-resistant tuberculosis (MDR-TB) treatment. However, among children with MDR-TB, there are no linezolid…”
Get full text

Inclusion of key populations in clinical trials of new antituberculosis treatments: Current barriers and recommendations for pregnant and lactating women, children, and HIV-infected persons by Gupta, Amita, Hughes, Michael D, Garcia-Prats, Anthony J, McIntire, Katherine, Hesseling, Anneke C

“…Amita Gupta and colleagues discuss priorities in clinical research aimed at improving tuberculosis prevention and treatment in pregnant women, children, and…”
Get full text

Early mortality in tuberculosis patients initially lost to follow up following diagnosis in provincial hospitals and primary health care facilities in Western Cape, South Africa by Osman, Muhammad, Meehan, Sue-Ann, von Delft, Arne, Du Preez, Karen, Dunbar, Rory, Marx, Florian M, Boulle, Andrew, Welte, Alex, Naidoo, Pren, Hesseling, Anneke C

“…In South Africa, low tuberculosis (TB) treatment coverage and high TB case fatality remain important challenges. Following TB diagnosis, patients must link…”
Get full text

Has the COVID-19 pandemic had an effect on the incidence and severity of anorexia nervosa referrals in young people? by Hesseling, Anna

Get full text

Interferon-gamma release assays and childhood tuberculosis: systematic review and meta-analysis [Review article] by MANDALAKAS, A. M, DETJEN, A. K, HESSELING, A. C, BENEDETTI, A, MENZIES, D

“…BACKGROUND: Children infected with Mycobacterium tuberculosis have significant risk of developing tuberculosis (TB) and can therefore benefit from preventive…”
Get full text

A decline in tuberculosis diagnosis, treatment initiation and success during the COVID-19 pandemic, using routine health data in Cape Town, South Africa by Jennings, Karen, Lembani, Martina, Hesseling, Anneke C, Mbula, Nyameka, Mohr-Holland, Erika, Mudaly, Vanessa, Smith, Mariette, Osman, Muhammad, Meehan, Sue-Ann

“…Coronavirus disease (COVID-19) negatively impacted tuberculosis (TB) programs which were already struggling to meet End-TB targets globally. We aimed to…”
Get full text

Pharmaceutical cost dynamics for the treatment of rifampicin-resistant tuberculosis in children and adolescents in South Africa, India, and the Philippines by Wilkinson, Thomas, Garcia-Prats, Anthony J, Sachs, Tina, Paradkar, Mandar, Suryavanshi, Nishi, Kinikar, Aarti, Frias, Melchor V, Sinanovic, Edina, Hesseling, Anneke C, Seddon, James A, Palmer, Megan

“…Rifampicin-resistant (RR) tuberculosis (TB) in children is a major global health concern but is often neglected in economics research. Accurate cost…”
Get full text

Tuberculosis Disease during Pregnancy and Treatment Outcomes in HIV-Infected and Uninfected Women at a Referral Hospital in Cape Town by Bekker, Adrie, Schaaf, Hendrik S, Draper, Heather R, Kriel, Magdalena, Hesseling, Anneke C

“…Tuberculosis during pregnancy and treatment outcomes are poorly defined in high prevalence tuberculosis and HIV settings. A prospective cohort study of…”
Get full text

Utility of host markers detected in Quantiferon supernatants for the diagnosis of tuberculosis in children in a high-burden setting by Chegou, Novel N, Detjen, Anne K, Thiart, Lani, Walters, Elisabetta, Mandalakas, Anna M, Hesseling, Anneke C, Walzl, Gerhard

“…The diagnosis of childhood tuberculosis (TB) disease remains a challenge especially in young and HIV-infected children. Recent studies have identified…”
Get full text

Shorter Treatment for Nonsevere Tuberculosis in African and Indian Children by Turkova, Anna, Wills, Genevieve H., Wobudeya, Eric, Chabala, Chishala, Palmer, Megan, Kinikar, Aarti, Hissar, Syed, Choo, Louise, Musoke, Philippa, Mulenga, Veronica, Mave, Vidya, Joseph, Bency, LeBeau, Kristen, Thomason, Margaret J., Mboizi, Robert B., Kapasa, Monica, van der Zalm, Marieke M., Raichur, Priyanka, Bhavani, Perumal K., McIlleron, Helen, Demers, Anne-Marie, Aarnoutse, Rob, Love-Koh, James, Seddon, James A., Welch, Steven B., Graham, Stephen M., Hesseling, Anneke C., Gibb, Diana M., Crook, Angela M.

“…Completing 6 months of treatment for tuberculosis in children is a challenge. In this open-label trial involving 1204 children in sub-Saharan Africa and India,…”
Get full text

Acceptability of clofazimine capsules in children and adolescents with rifampicin-resistant TB by Wademan, D.T., Saule, Z., Marthinus, A., Viljoen, L., Nortier, E., Hughes, J., Courtney, I., Palmer, M., Garcia-Prats, A.J., Hesseling, A.C., Hoddinott, G.

Get full text

Archive-based Covert Channel in Sensor Streaming Data by Heßeling, Carina, Litzinger, Sebastian, Keller, Jörg

“…With the advent of the Internet-of-Things, sensor data streams are widespread and thus a promising target for network steganography including covert channels…”
Get full text

The natural history of childhood intra-thoracic tuberculosis: a critical review of literature from the pre-chemotherapy era [State of the Art] by MARAIS, B. J, GIE, R. P, SCHAAF, H. S, HESSELING, A. C, OBIHARA, C. C, STARKE, J. J, ENARSON, T. D. A, DONALD, P. R, BEYERS, N

“…The pre-chemotherapy literature documented the natural history of tuberculosis in childhood. These disease descriptions remain invaluable for guiding public…”
Get full text

Practical and psychosocial challenges faced by caregivers influence the acceptability of multidrug-resistant tuberculosis preventive therapy for young children by Wademan, Dillon T, Hoddinott, Graeme, Purchase, Susan E, Seddon, James A, Hesseling, Anneke C, Garcia-Prats, Anthony J, Reis, Ria, Reynolds, Lindsey J

“…Drug-resistant (DR) strains of Mycobacterium tuberculosis (M. tb) are increasingly recognised as a threat to global tuberculosis (TB) control efforts…”
Get full text

Improving child tuberculosis contact identification and screening in Lesotho: Results from a mixed-methods cluster-randomized implementation science study by Hirsch-Moverman, Yael, Howard, Andrea A, Mantell, Joanne E, Lebelo, Limakatso, Frederix, Koen, Wills, Aprielle, Hesseling, Anneke C, Nachman, Sharon, Maama, Llang B, El-Sadr, Wafaa M

“…Child tuberculosis (TB) contact management is recommended for preventing TB in children but its implementation is suboptimal in high TB/HIV-burden settings…”
Get full text

A review of the use of ethionamide and prothionamide in childhood tuberculosis by Thee, S, Garcia-Prats, A.J, Donald, P.R, Hesseling, A.C, Schaaf, H.S

“…Summary Ethionamide (ETH) and prothionamide (PTH), both thioamides, have proven efficacy in clinical studies and form important components for…”
Get full text

Fungal diversity in the gut microbiome of young South African children by Nel Van Zyl, K, Whitelaw, A C, Hesseling, A C, Seddon, J A, Demers, A-M, Newton-Foot, M

“…The fungal microbiome, or mycobiome, is a poorly described component of the gut ecosystem and little is known about its structure and development in children…”
Get full text

Safety and Immunogenicity of the Recombinant Mycobacterium bovis BCG Vaccine VPM1002 in HIV-Unexposed Newborn Infants in South Africa by Loxton, André G, Knaul, Julia K, Grode, Leander, Gutschmidt, Andrea, Meller, Christiane, Eisele, Bernd, Johnstone, Hilary, van der Spuy, Gian, Maertzdorf, Jeroen, Kaufmann, Stefan H E, Hesseling, Anneke C, Walzl, Gerhard, Cotton, Mark F

“…Tuberculosis is a global threat to which infants are especially vulnerable. Effective vaccines are required to protect infants from this devastating disease…”
Get full text

Tuberculosis prevention in children: a prospective community-based study in South Africa by Mandalakas, Anna M, Hesseling, Anneke C, Kay, Alexander, Du Preez, Karen, Martinez, Leonardo, Ronge, Lena, DiNardo, Andrew, Lange, Christoph, Kirchner, H Lester

“…Tuberculosis (TB) preventive therapy reduces TB risk in children. However, the effectiveness of TB preventive therapy in children living in high TB burden…”
Get full text

High Incidence of Tuberculosis among HIV-Infected Infants: Evidence from a South African Population-Based Study Highlights the Need for Improved Tuberculosis Control Strategies by Hesseling, A. C., Cotton, M. F., Jennings, T., Whitelaw, A., Johnson, L. F., Eley, B., Roux, P., Godfrey-Faussett, P., Schaaf, H. S.

“…Background. There are limited population-based estimates of tuberculosis incidence among human immunodeficiency virus (HIV)—infected and HIV-uninfected infants…”
Get full text