Search Results - "Hessel, Edith"

PI3K inhibitors in inflammation, autoimmunity and cancer by Stark, Anne-Katrien, Sriskantharajah, Srividya, Hessel, Edith M, Okkenhaug, Klaus

“…Highlights • Preclinical studies support us of PI3K inhibitors in autoimmunity and inflammation. • First in class PI3K inhibitor has been approved for…”
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Functions of T cells in asthma: more than just TH2 cells by Lloyd, Clare M., Hessel, Edith M.

“…Key Points Several T cell subsets are involved in the development of the diseases we call asthma, not just T helper 2 (T H 2) cells. Emerging data describe the…”
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Functions of T cells in asthma: more than just T(H)2 cells by Lloyd, Clare M, Hessel, Edith M

“…Asthma has been considered a T helper 2 (T(H)2) cell-associated inflammatory disease, and T(H)2-type cytokines, such as interleukin-4 (IL-4), IL-5 and IL-13,…”
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Influenza-induced monocyte-derived alveolar macrophages confer prolonged antibacterial protection by Aegerter, Helena, Kulikauskaite, Justina, Crotta, Stefania, Patel, Harshil, Kelly, Gavin, Hessel, Edith M., Mack, Matthias, Beinke, Soren, Wack, Andreas

“…Despite the prevalence and clinical importance of influenza, its long-term effect on lung immunity is unclear. Here we describe that following viral clearance…”
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Histamine-secreting microbes are increased in the gut of adult asthma patients by Barcik, Weronika, MSc, Pugin, Benoit, PhD, Westermann, Patrick, MSc, Perez, Noelia Rodriguez, PhD, Ferstl, Ruth, PhD, Wawrzyniak, Marcin, PhD, Smolinska, Sylwia, PhD, Jutel, Marek, MD, PhD, Hessel, Edith M., PhD, Michalovich, David, PhD, Akdis, Cezmi A., MD, Frei, Remo, PhD, O'Mahony, Liam, PhD

“…To the Editor: Microbiome-host interactions are believed to significantly influence host immunologic homeostatic mechanisms, whereas microbial dysbiosis has…”
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Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients by Michalovich, David, Rodriguez-Perez, Noelia, Smolinska, Sylwia, Pirozynski, Michal, Mayhew, David, Uddin, Sorif, Van Horn, Stephanie, Sokolowska, Milena, Altunbulakli, Can, Eljaszewicz, Andrzej, Pugin, Benoit, Barcik, Weronika, Kurnik-Lucka, Magdalena, Saunders, Ken A., Simpson, Karen D., Schmid-Grendelmeier, Peter, Ferstl, Ruth, Frei, Remo, Sievi, Noriane, Kohler, Malcolm, Gajdanowicz, Pawel, Graversen, Katrine B., Lindholm Bøgh, Katrine, Jutel, Marek, Brown, James R., Akdis, Cezmi A., Hessel, Edith M., O’Mahony, Liam

“…In order to improve targeted therapeutic approaches for asthma patients, insights into the molecular mechanisms that differentially contribute to disease…”
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IFNλ is a potent anti‐influenza therapeutic without the inflammatory side effects of IFNα treatment by Davidson, Sophia, McCabe, Teresa M, Crotta, Stefania, Gad, Hans Henrik, Hessel, Edith M, Beinke, Soren, Hartmann, Rune, Wack, Andreas

“…Influenza A virus (IAV)‐induced severe disease is characterized by infected lung epithelia, robust inflammatory responses and acute lung injury. Since type I…”
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Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists by Kanzler, Holger, Barrat, Franck J, Hessel, Edith M, Coffman, Robert L

“…The identification of the antigen recognition receptors for innate immunity, most notably the Toll-like receptors, has sparked great interest in therapeutic…”
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Airway host-microbiome interactions in chronic obstructive pulmonary disease by Wang, Zhang, Maschera, Barbara, Lea, Simon, Kolsum, Umme, Michalovich, David, Van Horn, Stephanie, Traini, Christopher, Brown, James R, Hessel, Edith M, Singh, Dave

“…Little is known about the interactions between the lung microbiome and host response in chronic obstructive pulmonary disease (COPD). We performed a…”
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Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition by Juss, Jatinder K, House, David, Amour, Augustin, Begg, Malcolm, Herre, Jurgen, Storisteanu, Daniel M L, Hoenderdos, Kim, Bradley, Glyn, Lennon, Mark, Summers, Charlotte, Hessel, Edith M, Condliffe, Alison, Chilvers, Edwin R

“…Acute respiratory distress syndrome is refractory to pharmacological intervention. Inappropriate activation of alveolar neutrophils is believed to underpin…”
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Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model by Edwards, Chris D., Luscombe, Chris, Eddershaw, Peter, Hessel, Edith M.

“…Purpose We developed and tested a novel Quantitative Structure-Activity Relationship (QSAR) model to better understand the physicochemical drivers of pulmonary…”
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PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner by Stark, Anne-Katrien, Chandra, Anita, Chakraborty, Krishnendu, Alam, Rafeah, Carbonaro, Valentina, Clark, Jonathan, Sriskantharajah, Srividya, Bradley, Glyn, Richter, Alex G., Banham-Hall, Edward, Clatworthy, Menna R., Nejentsev, Sergey, Hamblin, J. Nicole, Hessel, Edith M., Condliffe, Alison M., Okkenhaug, Klaus

“…Streptococcus pneumoniae is a major cause of pneumonia and a leading cause of death world-wide. Antibody-mediated immune responses can confer protection…”
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Safety, Tolerability, and Pharmacokinetics of a New Formulation of Nemiralisib Administered via a Dry Powder Inhaler to Healthy Individuals by Wilson, Robert, Templeton, Alison, Leemereise, Claudia, Eames, Rhena, Banham-Hall, Edward, Hessel, Edith M., Cahn, Anthony

“…Nemiralisib, a phosphoinositide 3-kinase δ inhibitor, is being investigated as an immunomodulatory agent with anti-inflammatory properties in chronic…”
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Membrane nanoclusters of FcγRI segregate from inhibitory SIRPα upon activation of human macrophages by Lopes, Filipa B, Bálint, Štefan, Valvo, Salvatore, Felce, James H, Hessel, Edith M, Dustin, Michael L, Davis, Daniel M

“…Signal integration between activating Fc receptors and inhibitory signal regulatory protein α (SIRPα) controls macrophage phagocytosis. Here, using dual-color…”
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In situ targeted base editing of bacteria in the mouse gut by Brödel, Andreas K., Charpenay, Loïc H., Galtier, Matthieu, Fuche, Fabien J., Terrasse, Rémi, Poquet, Chloé, Havránek, Jan, Pignotti, Simone, Krawczyk, Antonina, Arraou, Marion, Prevot, Gautier, Spadoni, Dalila, Yarnall, Matthew T. N., Hessel, Edith M., Fernandez-Rodriguez, Jesus, Duportet, Xavier, Bikard, David

“…Microbiome research is now demonstrating a growing number of bacterial strains and genes that affect our health 1 . Although CRISPR-derived tools have shown…”
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Corrected Super-Resolution Microscopy Enables Nanoscale Imaging of Autofluorescent Lung Macrophages by Ambrose, Ashley R., Dechantsreiter, Susanne, Shah, Rajesh, Montero, M. Angeles, Quinn, Anne Marie, Hessel, Edith M., Beinke, Soren, Tannahill, Gillian M., Davis, Daniel M.

“…Observing the cell surface and underlying cytoskeleton at nanoscale resolution using super-resolution microscopy has enabled many insights into cell signaling…”
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Intranasal Bifidobacterium longum protects against viral-induced lung inflammation and injury in a murine model of lethal influenza infection by Groeger, David, Schiavi, Elisa, Grant, Ray, Kurnik-Łucka, Magdalena, Michalovich, David, Williamson, Rick, Beinke, Soren, Kiely, Barry, Akdis, Cezmi A, Hessel, Edith M, Shanahan, Fergus, O’ Mahony, Liam

“…Prophylactic strategies are urgently needed for prevention of severe inflammatory responses to respiratory viral infections. Bacterial-host interactions may…”
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The FAM13A Long Isoform Regulates Cilia Movement and Coordination in Airway Mucociliary Transport by Howes, Ashleigh, Rogerson, Clare, Belyaev, Nikolai, Karagyozova, Tina, Rapiteanu, Radu, Fradique, Ricardo, Pellicciotta, Nicola, Mayhew, David, Hurd, Catherine, Crotta, Stefania, Singh, Tanya, Dingwell, Kevin, Myatt, Anniek, Arad, Navot, Hasan, Hikmatyar, Bijlsma, Hielke, Panjwani, Aliza, Vijayan, Vinaya, Young, George, Bridges, Angela, Petit-Frere, Sebastien, Betts, Joanna, Larminie, Chris, Smith, James C, Hessel, Edith M, Michalovich, David, Walport, Louise, Cicuta, Pietro, Powell, Andrew J, Beinke, Soren, Wack, Andreas

“…Single nucelotide polymorphisms (SNPs) at the locus are among the most commonly reported risk alleles associated with chronic obstructive pulmonary disease…”
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The effects of repeated Toll-like receptors 2 and 4 stimulation in COPD alveolar macrophages by Lea, Simon R, Reynolds, Sophie L, Kaur, Manminder, Simpson, Karen D, Hall, Simon R, Hessel, Edith M, Singh, Dave

“…COPD is a progressive inflammatory airway disease characterized by increased numbers of alveolar macrophages in the lungs. Bacterial colonization of the lungs…”
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Safety, Tolerability, and Pharmacokinetics of Single and Repeat Doses of Nemiralisib Administered via the Ellipta Dry Powder Inhaler to Healthy Subjects by Wilson, Robert, Jarvis, Emily, Montembault, Mickael, Hamblin, J. Nicole, Hessel, Edith M., Cahn, Anthony

“…Novel therapies to treat chronic obstructive pulmonary disease are highly desirable. The safety, tolerability, and pharmacokinetic (PK) parameters of…”
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