Search Results - "Hess, L."
-
1
The pathogenesis of mixed-lineage leukemia
Published in Annual review of pathology (01-01-2012)“…Aggressive leukemias arise in both children and adults as a result of rearrangements to the mixed-lineage leukemia gene (MLL) located on chromosome 11q23. MLL…”
Get full text
Journal Article -
2
Lightning strikes as a major facilitator of prebiotic phosphorus reduction on early Earth
Published in Nature communications (16-03-2021)“…When hydrated, phosphides such as the mineral schreibersite, (Fe,Ni) 3 P, allow for the synthesis of important phosphorus-bearing organic compounds. Such…”
Get full text
Journal Article -
3
Deregulation of the HOXA9/MEIS1 axis in acute leukemia
Published in Current opinion in hematology (01-07-2016)“…HOXA9 is a homeodomain transcription factor that plays an essential role in normal hematopoiesis and acute leukemia, in which its overexpression is strongly…”
Get full text
Journal Article -
4
Drifting discrete Jovian radio bursts reveal acceleration processes related to Ganymede and the main aurora
Published in Nature communications (03-10-2023)“…Radio detection at high time-frequency resolutions is a powerful means of remotely studying electron acceleration processes. Radio bursts have characteristics…”
Get full text
Journal Article -
5
Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo
Published in Cancer cell (13-04-2015)“…Chromosomal translocations affecting mixed lineage leukemia gene (MLL) result in acute leukemias resistant to therapy. The leukemogenic activity of MLL fusion…”
Get full text
Journal Article -
6
Targeting MLL1 H3K4 Methyltransferase Activity in Mixed-Lineage Leukemia
Published in Molecular cell (23-01-2014)“…Here we report a comprehensive characterization of our recently developed inhibitor MM-401 that targets the MLL1 H3K4 methyltransferase activity. MM-401 is…”
Get full text
Journal Article -
7
CBX8, a Polycomb Group Protein, Is Essential for MLL-AF9-Induced Leukemogenesis
Published in Cancer cell (15-11-2011)“…Chromosomal translocations involving the mixed lineage leukemia ( MLL) gene lead to the development of acute leukemias. Constitutive HOX gene activation by MLL…”
Get full text
Journal Article -
8
Dual-season mapping of wetland inundation and vegetation for the central Amazon basin
Published in Remote sensing of environment (15-11-2003)“…Wetland extent was mapped for the central Amazon region, using mosaicked L-band synthetic aperture radar (SAR) imagery acquired by the Japanese Earth Resources…”
Get full text
Journal Article -
9
Sub-pixel mapping of urban land cover using multiple endmember spectral mixture analysis: Manaus, Brazil
Published in Remote sensing of environment (30-01-2007)“…The spatial and spectral variability of urban environments present fundamental challenges to deriving accurate remote sensing products for urban areas…”
Get full text
Journal Article -
10
Unique Cellular Interaction of Silver Nanoparticles: Size-Dependent Generation of Reactive Oxygen Species
Published in The journal of physical chemistry. B (30-10-2008)“…The rapid advancement of nanotechnology has created a vast array of engineered nanomaterials (ENMs) which have unique physical (size, shape, crystallinity,…”
Get full text
Journal Article -
11
Lifetime risk of a diagnosis of HIV infection in the United States
Published in Annals of epidemiology (01-04-2017)“…Abstract Purpose To estimate lifetime risk of receiving an HIV diagnosis in the United States if existing infection rates continue. Methods We used mortality,…”
Get full text
Journal Article -
12
Phage display as a tool for vaccine and immunotherapy development
Published in Bioengineering & translational medicine (01-01-2020)“…Bacteriophages, or phages, are viruses that specifically infect bacteria and coopt the cellular machinery to create more phage proteins, eventually resulting…”
Get full text
Journal Article -
13
Auroral Processes at the Giant Planets: Energy Deposition, Emission Mechanisms, Morphology and Spectra
Published in Space science reviews (01-04-2015)“…The ionospheric response to auroral precipitation at the giant planets is reviewed, using models and observations. The emission processes for aurorae at radio,…”
Get full text
Journal Article -
14
Early management of atrial fibrillation to prevent cardiovascular complications
Published in European heart journal (07-06-2014)“…Atrial fibrillation (AF) is generally considered a progressive disease, typically evolving from paroxysmal through persistent to 'permanent' forms, a process…”
Get full text
Journal Article -
15
Model of the Jovian magnetic field topology constrained by the Io auroral emissions
Published in Journal of Geophysical Research: Space Physics (01-05-2011)“…The determination of the internal magnetic field of Jupiter has been the object of many studies and publications. These models have been computed from the…”
Get full text
Journal Article Web Resource -
16
Syphilis Trends among Men Who Have Sex with Men in the United States and Western Europe: A Systematic Review of Trend Studies Published between 2004 and 2015
Published in PloS one (22-07-2016)“…Globally, men who have sex with men (MSM) are disproportionately burdened with syphilis. This review describes the published literature on trends in syphilis…”
Get full text
Journal Article -
17
Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia
Published in PLoS genetics (01-06-2012)“…We have developed an enhanced form of reduced representation bisulfite sequencing with extended genomic coverage, which resulted in greater capture of DNA…”
Get full text
Journal Article -
18
HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis
Published in Cancer cell (08-10-2018)“…Aberrant expression of HOXA9 is a prominent feature of acute leukemia driven by diverse oncogenes. Here we show that HOXA9 overexpression in myeloid and B…”
Get full text
Journal Article -
19
Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia
Published in Nature chemical biology (29-01-2012)“…MLL fusion genes often encode leukemogenic proteins that depend on interaction with menin, a component of the MLL SET1-like histone methyltransferase complex…”
Get full text
Journal Article -
20
Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth
Published in Cancer research (Chicago, Ill.) (01-06-2008)“…Therapy for advanced prostate cancer centers on suppressing systemic androgens and blocking activation of the androgen receptor (AR). Despite anorchid serum…”
Get full text
Journal Article