Search Results - "Hess, Allan"

Aldehyde dehydrogenase expression drives human regulatory T cell resistance to posttransplantation cyclophosphamide by Kanakry, Christopher G, Ganguly, Sudipto, Zahurak, Marianna, Bolaños-Meade, Javier, Thoburn, Christopher, Perkins, Brandy, Fuchs, Ephraim J, Jones, Richard J, Hess, Allan D, Luznik, Leo

“…High-dose, posttransplantation cyclophosphamide (PTCy) is an effective strategy for preventing graft-versus-host disease (GVHD) after allogeneic blood or…”
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High-dose cyclophosphamide as single-agent, short-course prophylaxis of graft-versus-host disease by Luznik, Leo, Bolaños-Meade, Javier, Zahurak, Marianna, Chen, Allen R., Smith, B. Douglas, Brodsky, Robert, Huff, Carol Ann, Borrello, Ivan, Matsui, William, Powell, Jonathan D., Kasamon, Yvette, Goodman, Steven N., Hess, Allan, Levitsky, Hyam I., Ambinder, Richard F., Jones, Richard J., Fuchs, Ephraim J.

“…Because of its potent immunosuppressive yet stem cell–sparing activity, high-dose cyclophosphamide was tested as sole prophylaxis of graft-versus-host disease…”
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Equal opportunity targeting in chronic GVHD by Hess, Allan D.

“…In this issue of Blood, studies by Rangarajan et al comprehensively analyzing the clonotypic T-cell response provide evidence that the effector T cells that…”
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Dual mTORC1/mTORC2 inhibition diminishes Akt activation and induces Puma-dependent apoptosis in lymphoid malignancies by Gupta, Mamta, Hendrickson, Andrea E. Wahner, Yun, Seong Seok, Han, Jing Jing, Schneider, Paula A., Koh, Brian D., Stenson, Mary J., Wellik, Linda E., Shing, Jennifer C., Peterson, Kevin L., Flatten, Karen S., Hess, Allan D., Smith, B. Douglas, Karp, Judith E., Barr, Sharon, Witzig, Thomas E., Kaufmann, Scott H.

“…The mammalian target of rapamycin (mTOR) plays crucial roles in proliferative and antiapoptotic signaling in lymphoid malignancies. Rapamycin analogs, which…”
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Poly(ADP-ribose) Polymerase Inhibitors Sensitize Cancer Cells to Death Receptor-mediated Apoptosis by Enhancing Death Receptor Expression by Meng, X.Wei, Koh, Brian D., Zhang, Jin-San, Flatten, Karen S., Schneider, Paula A., Billadeau, Daniel D., Hess, Allan D., Smith, B.Douglas, Karp, Judith E., Kaufmann, Scott H.

“…Recombinant human tumor necrosis factor-α-related apoptosis inducing ligand (TRAIL), agonistic monoclonal antibodies to TRAIL receptors, and small molecule…”
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4EBP1/c-MYC/PUMA and NF-κB/EGR1/BIM pathways underlie cytotoxicity of mTOR dual inhibitors in malignant lymphoid cells by Yun, Seongseok, Vincelette, Nicole D., Knorr, Katherine L.B., Almada, Luciana L., Schneider, Paula A., Peterson, Kevin L., Flatten, Karen S., Dai, Haiming, Pratz, Keith W., Hess, Allan D., Smith, B.Douglas, Karp, Judith E., Hendrickson, Andrea E.Wahner, Fernandez-Zapico, Martin E., Kaufmann, Scott H.

“…The mammalian target of rapamycin (mTOR), a kinase that regulates proliferation and apoptosis, has been extensively evaluated as a therapeutic target in…”
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CXCR4 Chemokine Receptor Signaling Induces Apoptosis in Acute Myeloid Leukemia Cells via Regulation of the Bcl-2 Family Members Bcl-XL, Noxa, and Bak by Kremer, Kimberly N., Peterson, Kevin L., Schneider, Paula A., Meng, X. Wei, Dai, Haiming, Hess, Allan D., Smith, B. Douglas, Rodriguez-Ramirez, Christie, Karp, Judith E., Kaufmann, Scott H., Hedin, Karen E.

“…The CXCR4 chemokine receptor promotes survival of many different cell types. Here, we describe a previously unsuspected role for CXCR4 as a potent inducer of…”
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Effect of CHK1 Inhibition on CPX-351 Cytotoxicity in vitro and ex vivo by Vincelette, Nicole D., Ding, Husheng, Huehls, Amelia M., Flatten, Karen S., Kelly, Rebecca L., Kohorst, Mira A., Webster, Jonathan, Hess, Allan D., Pratz, Keith W., Karnitz, Larry M., Kaufmann, Scott H.

“…CPX-351 is a liposomally encapsulated 5:1 molar ratio of cytarabine and daunorubicin that recently received regulatory approval for the treatment of…”
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Effects of Selective Checkpoint Kinase 1 Inhibition on Cytarabine Cytotoxicity in Acute Myelogenous Leukemia Cells In Vitro by SCHENK, Erin L, KOH, Brian D, FLATTEN, Karen S, PETERSON, Kevin L, PARRY, David, HESS, Allan D, SMITH, B. Douglas, KARP, Judith E, KARNITZ, Larry M, KAUFMANN, Scott H

“…Previous studies have shown that the replication checkpoint, which involves the kinases ataxia telangiectasia mutated and Rad3 related (ATR) and Chk1,…”
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Histone Deacetylase Inhibitors Target the Leukemic Microenvironment by Enhancing a Nherf1-Protein Phosphatase 1α-TAZ Signaling Pathway in Osteoblasts by Kremer, Kimberly N., Dudakovic, Amel, Hess, Allan D., Smith, B. Douglas, Karp, Judith E., Kaufmann, Scott H., Westendorf, Jennifer J., van Wijnen, Andre J., Hedin, Karen E.

“…Disrupting the protective signals provided by the bone marrow microenvironment will be critical for more effective combination drug therapies for acute myeloid…”
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Separation of GVHD and GVL by Hess, Allan D.

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Association of Foxp3 regulatory gene expression with graft-versus-host disease by Miura, Yuji, Thoburn, Christopher J., Bright, Emilie C., Phelps, Michele L., Shin, Tahiro, Matsui, Elizabeth C., Matsui, William H., Arai, Sally, Fuchs, Ephraim J., Vogelsang, Georgia B., Jones, Richard J., Hess, Allan D.

“…Graft-versus-host disease (GVHD) is characterized by an impairment of mechanisms that underlie the development of immunologic tolerance. Although the cytokine…”
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Reconstitution of self-tolerance after hematopoietic stem cell transplantation by Hess, Allan D.

“…Graft-versus-host disease (GVHD) is a major complication of allogeneic bone marrow or hematopoietic stem cell transplantation. GVHD is thought to be primarily…”
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Osteoblasts Protect AML Cells From SDF-1-Induced Apoptosis by Kremer, Kimberly N., Dudakovic, Amel, McGee-Lawrence, Meghan E., Philips, Rachael L., Hess, Allan D., Smith, B. Douglas, van Wijnen, Andre J., Karp, Judith E., Kaufmann, Scott H., Westendorf, Jennifer J., Hedin, Karen E.

“…ABSTRACT The bone marrow provides a protective environment for acute myeloid leukemia (AML) cells that often allows leukemic stem cells to survive standard…”
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Early lymphocyte recovery after intensive timed sequential chemotherapy for acute myelogenous leukemia: peripheral oligoclonal expansion of regulatory T cells by Kanakry, Christopher G., Hess, Allan D., Gocke, Christopher D., Thoburn, Christopher, Kos, Ferdynand, Meyer, Christian, Briel, Janet, Luznik, Leo, Smith, B. Douglas, Levitsky, Hyam, Karp, Judith E.

“…Few published studies characterize early lymphocyte recovery after intensive chemotherapy for acute myelogenous leukemia (AML). To test the hypothesis that…”
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Differential expression of degradome components in cutaneous squamous cell carcinomas by Prasad, Nijaguna B, Fischer, Anne C, Chuang, Alice Y, Wright, Jerry M, Yang, Ting, Tsai, Hua-Ling, Westra, William H, Liegeois, Nanette J, Hess, Allan D, Tufaro, Anthony P

“…Although the cure rate for cutaneous squamous cell carcinoma is high, the diverse spectrum of squamous cell carcinoma has made it difficult for early…”
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Prognostic factors and risk stratification in early mycosis fungoides by Vonderheid, Eric C., Pavlov, Igor, Delgado, Julio C., Martins, Thomas B., Telang, Gladys H., Hess, Allan D., Kadin, Marshall E.

“…Abstract Available demographic, clinical, histologic, immunohistochemical and laboratory findings, including serum cytokine/cytokine receptor levels, obtained…”
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Assessment of Drug Sensitivity in Hematopoietic Stem and Progenitor Cells from Acute Myelogenous Leukemia and Myelodysplastic Syndrome Ex Vivo by Knorr, Katherine L.B., Finn, Laura E., Smith, B. Douglas, Hess, Allan D., Foran, James M., Karp, Judith E., Kaufmann, Scott H.

“…Current understanding suggests that malignant stem and progenitor cells must be reduced or eliminated for prolonged remissions in myeloid neoplasms such as…”
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CD20, AIF-1, and TGF-β in graft-versus-host disease: a study of mRNA expression in histologically matched skin biopsies by Wu, Julie M, Thoburn, Christopher J, Wisell, Joshua, Farmer, Evan R, Hess, Allan D

“…Graft-versus-host disease is the leading cause of non-relapse mortality after allogeneic bone marrow transplantation. The cell-mediated immune mechanisms that…”
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Chemokine Receptor Expression by Leukemic T Cells of Cutaneous T-Cell Lymphoma: Clinical and Histopathological Correlations by Capriotti, Elisabetta, Vonderheid, Eric C., Thoburn, Christopher J., Bright, Emilie C., Hess, Allan D.

“…Chemokine receptors expressed by normal and neoplastic lymphocytes provide an important mechanism for cells to traffic into the skin and skin-associated lymph…”
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