Search Results - "Heslop, HE"

Adenovirus infection after pediatric bone marrow transplantation by HALE, G. A, HESLOP, H. E, KRANCE, R. A, BRENNER, M. A, JAYAWARDENE, D, SRIVASTAVA, D. K, PATRICK, C. C

“…Retrospective analysis of 206 patients undergoing 215 consecutive bone marrow transplants (BMT) at St Jude Children's Research Hospital between November 1990…”
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Efficient infection of primitive hematopoietic stem cells by modified adenovirus by YOTNDA, P, ONISHI, H, HESLOP, H. E, SHAYAKHMETOV, D, LIEBER, A, BRENNER, M, DAVIS, A

“…Almost all studies of adenoviral vector-mediated gene transfer have made use of the adenovirus type 5 (Ad5). Unfortunately, Ad5 has been ineffective at…”
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Guillain-Barré syndrome after allogeneic hematopoietic stem cell transplantation by RODRIGUEZ, V, KUEHNLE, I, HESLOP, H. E, KHAN, S, KRANCE, R. A

“…Guillain-Barré syndrome is a rare complication in the setting of hematopoietic stem cell transplantation. We report three children with T cell…”
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Bone marrow transplantation for therapy-induced acute myeloid leukemia in children with previous lymphoid malignancies by HALE, G. A, HESLOP, H. E, BOWMAN, L. C, ROCHESTER, R. A, PUI, C.-H, BRENNER, M. K, KRANCE, R. A

“…Twenty-one children who developed therapy-related acute myeloid leukemia after treatment for acute lymphoblastic leukemia received allogeneic bone marrow…”
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Energy expenditure in children undergoing hematopoietic stem cell transplantation by RINGWALD-SMITH, K. A, HESLOP, H. E, KRANCE, R. A, MACKERT, P. W, HANCOCK, M. L, STRICKLIN, L. M, BOWMAN, L. C, HALE, G. A

“…Prior studies suggest that patients undergoing hematopoietic stem cell transplantation (HSCT) for malignancy have nutritional needs that are greater than their…”
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Post-transplant lymphoproliferative disorders by Gottschalk, Stephen, Rooney, Cliona M, Heslop, Helen E

“…Post-transplant lymphoproliferative disorder (PTLD) is a life-threatening complication after hematopoietic stem cell or solid organ transplantation. The…”
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A Chimeric T Cell Antigen Receptor that Augments Cytokine Release and Supports Clonal Expansion of Primary Human T Cells by Pulè, Martin A, Straathof, Karin C, Dotti, Gianpietro, Heslop, Helen E, Rooney, Cliona M, Brenner, Malcolm K

“…The transduction of primary T cells to express chimeric T cell receptors (cTCR) for redirected targeting of tumor cells is an attractive strategy for…”
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An inducible caspase 9 safety switch for T-cell therapy by Straathof, Karin C., Pulè, Martin A., Yotnda, Patricia, Dotti, Gianpietro, Vanin, Elio F., Brenner, Malcolm K., Heslop, Helen E., Spencer, David M., Rooney, Cliona M.

“…The efficacy of adoptive T-cell therapy as treatment for malignancies may be enhanced by genetic modification of infused cells. However, oncogenic events due…”
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Abstract P3-05-07: Improving CAR T cell function by reversing the immunosuppressive tumor environment of breast cancer by Bajgain, P, Tawinwung, S, Watanabe, N, Sukumaran, S, Anurathapan, U, Heslop, HE, Rooney, CM, Brenner, M, Leen, AM, Vera, JF

“…Abstract Adoptive transfer of T cells redirected to tumor-associated antigens (TAAs) by expression of chimeric antigen receptors (CARs) can produce tumor…”
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Cytotoxic T lymphocyte therapy for Epstein-Barr virus+ Hodgkin's disease by Bollard, Catherine M, Aguilar, Laura, Straathof, Karin C, Gahn, Benedikt, Huls, M Helen, Rousseau, Alexandra, Sixbey, John, Gresik, M Victoria, Carrum, George, Hudson, Melissa, Dilloo, Dagmar, Gee, Adrian, Brenner, Malcolm K, Rooney, Cliona M, Heslop, Helen E

“…Epstein Barr virus (EBV)+ Hodgkin's disease (HD) expresses clearly identified tumor antigens derived from the virus and could, in principle, be a target for…”
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Allogeneic bone marrow transplantation in children failing prior autologous bone marrow transplantation by HALE, G. A, XIN TONG, WOODARD, J. P, BOWMAN, L. C, BENAIM, E, CUNNINGHAM, J. M, HESLOP, H. E, HORWITZ, E. M, LEUNG, W, ROCHESTER, R. J, SHEARER, P. D, SRIVASTAVA, D. K

“…Twenty-three children with de novo acute myelogenous leukemia (AML) (n = 20), secondary AML (n = 1), or non-Hodgkin's lymphoma (NHL) (n = 2) underwent…”
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Accelerated Production of Antigen-specific T Cells for Preclinical and Clinical Applications Using Gas-permeable Rapid Expansion Cultureware (G-Rex) by VERA, Juan F, BRENNER, Lara J, ROONEY, Cliona M, GERDEMANN, Ulrike, NGO, Minhtran C, SILI, Uluhan, HAO LIU, WILSON, John, DOTTI, Gianpietro, HESLOP, Helen E, LEEN, Ann M

“…The clinical manufacture of antigen-specific cytotoxic T lymphocytes (CTLs) for adoptive immunotherapy is limited by the complexity and time required to…”
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Treatment of nasopharyngeal carcinoma with Epstein-Barr virus–specific T lymphocytes by Straathof, Karin C.M., Bollard, Catherine M., Popat, Uday, Huls, M.Helen, Lopez, Teresita, Morriss, M.Craig, Gresik, Mary V., Gee, Adrian P., Russell, Heidi V., Brenner, Malcolm K., Rooney, Cliona M., Heslop, Helen E.

“…Conventional treatment for nasopharyngeal carcinoma (NPC) frequently fails and is accompanied by severe long-term side effects. Since virtually all…”
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Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis by APPEL, S. H, ENGELHARDT, J. I, BRENNER, M. K, POPAT, U, HENKEL, J. S, SIKLOS, L, BEERS, D. R, YEN, A. A, SIMPSON, E. P, LUO, Y, CARRUM, G, HESLOP, H. E

“…Amyotrophic lateral sclerosis (ALS), an inexorably progressive motoneuron disease, is accompanied by significantly increased markers of inflammation. These…”
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Survival outcomes of allogeneic hematopoietic cell transplants with EBV‐positive or EBV‐negative post‐transplant lymphoproliferative disorder, A CIBMTR study by Naik, Seema, Riches, Marcie, Hari, Parameswaran, Kim, Soyoung, Chen, Min, Bachier, Carlos, Shaughnessy, Paul, Hill, Joshua, Ljungman, Per, Battiwalla, Minoo, Chhabra, Saurabh, Daly, Andrew, Storek, Jan, Ustun, Celalettin, Diaz, Miguel Angel, Cerny, Jan, Beitinjaneh, Amer, Yared, Jean, Brown, Valerie, Page, Kristin, Dahi, Parastoo B., Ganguly, Siddhartha, Seo, Sachiko, Chao, Nelson, Freytes, Cesar O., Saad, Ayman, Savani, Bipin N., Woo Ahn, Kwang, Boeckh, Michael, Heslop, Helen E., Lazarus, Hillard M., Auletta, Jeffery J., Kamble, Rammurti T.

“…Background Post‐transplant lymphoproliferative disorders (PTLD) are associated with significant morbidity and mortality following allogeneic hematopoietic cell…”
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Human papillomavirus type 16 E6/E7-specific cytotoxic T lymphocytes for adoptive immunotherapy of HPV-associated malignancies by Ramos, Carlos A, Narala, Neeharika, Vyas, Gayatri M, Leen, Ann M, Gerdemann, Ulrike, Sturgis, Erich M, Anderson, Matthew L, Savoldo, Barbara, Heslop, Helen E, Brenner, Malcolm K, Rooney, Cliona M

“…Vaccines prevent human papillomavirus (HPV)-associated cancer but, although these tumors express foreign, viral antigens (E6 and E7 proteins), they have little…”
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The immunogenicity of virus-derived 2A sequences in immunocompetent individuals by Arber, C, Abhyankar, H, Heslop, H E, Brenner, M K, Liu, H, Dotti, G, Savoldo, B

“…Genetic engineering of T cells for adoptive immunotherapy in cancer patients has shown significant promise. To ensure optimal antitumor activity and safety,…”
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Quantitative EBV Viral Loads and Immunosuppression Alterations can Decrease PTLD Incidence in Pediatric Liver Transplant Recipients by Lee, Timothy C., Savoldo, Barbara, Rooney, Cliona M., Heslop, Helen E., Gee, Adrian P., Caldwell, Yvette, Barshes, Neal R., Scott, Jaymee D., Bristow, Lisa J., O'Mahony, Christine A., Goss, John A.

“…Epstein–Barr virus (EBV) is a common viral infection in pediatric liver transplant patients and can lead to development of post‐transplant lymphoproliferative…”
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Prompt versus preemptive intervention for EBV lymphoproliferative disease by Wagner, Hans-Joachim, Cheng, Yee Chung, Huls, M. Helen, Gee, Adrian P., Kuehnle, Ingrid, Krance, Robert A., Brenner, Malcolm K., Rooney, Cliona M., Heslop, Helen E.

“…Posttransplantation lymphoproliferative disorders (PTLDs) caused by uncontrolled expansion of Epstein-Barr virus (EBV)–infected B cells after hematopoietic…”
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Infusion of Cytotoxic T Cells for the Prevention and Treatment of Epstein-Barr Virus–Induced Lymphoma in Allogeneic Transplant Recipients by Rooney, Cliona M., Smith, Colton A., Ng, Catherine Y.C., Loftin, Susan K., Sixbey, John W., Gan, Yanjun, Srivastava, Deo-Kumar, Bowman, Laura C., Krance, Robert A., Brenner, Malcolm K., Heslop, Helen E.

“…Epstein-Barr virus (EBV) causes potentially lethal immunoblastic lymphoma in up to 25% of children receiving bone marrow transplants from unrelated or…”
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