Search Results - "Heslop, H E"

Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma leukemia effects and safety by Hoyos, V, Savoldo, B, Quintarelli, C, Mahendravada, A, Zhang, M, Vera, J, Heslop, H E, Rooney, C M, Brenner, M K, Dotti, G

“…T lymphocytes expressing a chimeric antigen receptor (CAR) targeting the CD19 antigen (CAR.19) may be of value for the therapy of B-cell malignancies. Because…”
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Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis by APPEL, S. H, ENGELHARDT, J. I, BRENNER, M. K, POPAT, U, HENKEL, J. S, SIKLOS, L, BEERS, D. R, YEN, A. A, SIMPSON, E. P, LUO, Y, CARRUM, G, HESLOP, H. E

“…Amyotrophic lateral sclerosis (ALS), an inexorably progressive motoneuron disease, is accompanied by significantly increased markers of inflammation. These…”
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Adenovirus infection rates in pediatric recipients of alternate donor allogeneic bone marrow transplants receiving either antithymocyte globulin (ATG) or alemtuzumab (Campath) by MYERS, G. D, KRANCE, R. A, WEISS, H, KUEHNLE, I, DEMMLER, G, HESLOP, H. E, BOLLARD, C. M

“…Infectious complications due to adenovirus are of increasing concern after allogeneic stem cell transplantation. Over the past 4 years, we have modified our…”
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Adenovirus infection after pediatric bone marrow transplantation by HALE, G. A, HESLOP, H. E, KRANCE, R. A, BRENNER, M. A, JAYAWARDENE, D, SRIVASTAVA, D. K, PATRICK, C. C

“…Retrospective analysis of 206 patients undergoing 215 consecutive bone marrow transplants (BMT) at St Jude Children's Research Hospital between November 1990…”
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Reconstitution of adenovirus-specific cell-mediated immunity in pediatric patients after hematopoietic stem cell transplantation by MYERS, G. D, BOLLARD, C. M, WU, M-F, WEISS, H, ROONEY, C. M, HESLOP, H. E, LEEN, A. M

“…Adenovirus (adv) is a significant cause of morbidity and mortality in pediatric hematopoietic stem cell transplant recipients, and control of infection seems…”
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The immunogenicity of virus-derived 2A sequences in immunocompetent individuals by Arber, C, Abhyankar, H, Heslop, H E, Brenner, M K, Liu, H, Dotti, G, Savoldo, B

“…Genetic engineering of T cells for adoptive immunotherapy in cancer patients has shown significant promise. To ensure optimal antitumor activity and safety,…”
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Transmission of integrated human herpesvirus-6 in allogeneic hematopoietic stem cell transplantation by KAMBIE, R. T, CLARK, D. A, LEONG, H. N, HESLOP, H. E, BRENNER, M. K, CARRUM, G

“…Human herpesvirus 6 (HHV-6) viremia, as detected by polymerase chain amplification, occurs in approximately half of allogeneic hematopoietic stem cell…”
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Efficient infection of primitive hematopoietic stem cells by modified adenovirus by YOTNDA, P, ONISHI, H, HESLOP, H. E, SHAYAKHMETOV, D, LIEBER, A, BRENNER, M, DAVIS, A

“…Almost all studies of adenoviral vector-mediated gene transfer have made use of the adenovirus type 5 (Ad5). Unfortunately, Ad5 has been ineffective at…”
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Efficacy of deferred dosing of granulocyte colony-stimulating factor in autologous hematopoietic transplantation for multiple myeloma by Cox, J E, Campos, S, Wu, J, May, R, Liu, H, Ramos, C A, Carrum, G, Heslop, H E, Brenner, M K, Kamble, R T

“…Routine administration of G-CSF following autologous hematopoietic SCT (ASCT) expedites ANC recovery and reduces hospitalization by 1–2 days; it has no impact…”
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Neuropathic dermatomes and cutaneous ulceration in patients with chronic GVHD by Kamble, R T, Scholoff, A, Obi, A G, Heslop, H E, Brenner, M K, Carrum, G

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Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation by Rooney, C M, Smith, C A, Ng, C Y, Loftin, S, Li, C, Krance, R A, Brenner, M K, Heslop, H E

“…Reactivation of Epstein-Barr virus (EBV) after bone-marrow transplantation leads in many cases to lymphoproliferative disease that responds poorly to standard…”
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Cytomegalovirus (CMV) infections and CMV-specific cellular immune reconstitution following reduced intensity conditioning allogeneic stem cell transplantation with Alemtuzumab by LAMBA, R, CARRUM, G, MYERS, G. D, BOLLARD, C. M, KRANCE, R. A, HESLOP, H. E, BRENNER, M. K, POPAT, U

“…We studied the incidence and recurrence of Cytomegalovirus (CMV) infection and reactivation in 38 recipients of Alemtuzumab reduced intensity conditioning-stem…”
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Comparison of the efficiency of transduction of leukemic cells by fiber-modified adenoviruses by Yotnda, P, Zompeta, C, Heslop, H E, Andreeff, M, Brenner, M K, Marini, F

“…Efficient gene transfer with adenoviral type 5 (Ad5) vectors depends on the initial attachment of their fiber, which binds the coxsackie-adenovirus receptor…”
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Selective elimination of a chemoresistant side population of B-CLL cells by cytotoxic T lymphocytes in subjects receiving an autologous hCD40L IL-2 tumor vaccine by Foster, A E, Okur, F V, Biagi, E, Lu, A, Dotti, G, Yvon, E, Savoldo, B, Carrum, G, Goodell, M A, Heslop, H E, Brenner, M K

“…Side-population (SP) analysis identifies precursor cells in normal and malignant tissues. Cells with this phenotype have increased resistance to many cytotoxic…”
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CD20 monoclonal antibody (rituximab) for therapy of Epstein-Barr virus lymphoma after hemopoietic stem-cell transplantation by Kuehnle, Ingrid, Huls, M. Helen, Liu, Zhensheng, Semmelmann, Micah, Krance, Robert A., Brenner, Malcolm K., Rooney, Cliona M., Heslop, Helen E.

“…After bone marrow transplantation (BMT) using T-cell–depleted marrow from an unrelated donor or HLA-mismatched related donor, the risk of developing…”
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Human herpesvirus-6 encephalitis following allogeneic hematopoietic stem cell transplantation by VU, T, CARRUM, G, HUTTON, G, HESLOP, H. E, BRENNER, M. K, KAMBLE, R

“…Immunosuppressive monoclonal antibodies directed to immune system cells may reduce rejection and graft versus host disease (GvHD) after allogeneic stem cell…”
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Robust T cell responses to aspergillosis in chronic granulomatous disease: implications for immunotherapy by Cruz, C. R. Y., Lam, S., Hanley, P. J., Bear, A. S., Langston, C., Cohen, A. J., Liu, H., Martinez, C. A., Krance, R. A., Heslop, H. E., Rooney, C. M., Hanson, I. C., Bollard, C. M.

“…Summary Chronic granulomatous disease (CGD) patients are highly susceptible to invasive aspergillosis and might benefit from aspergillus‐specific T cell…”
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Guillain-Barré syndrome after allogeneic hematopoietic stem cell transplantation by RODRIGUEZ, V, KUEHNLE, I, HESLOP, H. E, KHAN, S, KRANCE, R. A

“…Guillain-Barré syndrome is a rare complication in the setting of hematopoietic stem cell transplantation. We report three children with T cell…”
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Outcome of reduced-intensity allogeneic hematopoietic stem cell transplantation (RISCT) using antilymphocyte antibodies in patients with high-risk acute myeloid leukemia (AML) by POPAT, U, HESLOP, H. E, DURETT, A, MAY, R, KRANCE, R. A, BRENNER, M. K, CARRUM, G

“…Hemopoietic stem cell transplantation (SCT) with fully ablative conditioning is associated with an age-related increase in treatment-related mortality. It is…”
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Combined autologous CD30.CAR‐T cells and nivolumab in patients with relapsed or refractory classical Hodgkin Lymphoma after failure of frontline therapy (ACTION study) by Ahmed, S., Mei, M., Kurtz, D. M., Beitinjaneh, A., Grover, N. S., Ramos, C. A., Chabon, J. J., Schultz, A., Ding, C., Myo, A., Alizadeh, A. A., Horak, I. D., Heslop, H. E.

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