Search Results - "Hesketh, T R"

No Effect of 60 Hz Electromagnetic Fields on MYC or β-Actin Expression in Human Leukemic Cells by Lacy-Hulbert, Adam, Wilkins, Roger C., Hesketh, T. Robin, Metcalfe, James C.

“…Epidemiological studies have shown weak correlations between exposure to extremely low-frequency electromagnetic fields (ELF EMFs) and the incidence of several…”
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The mechanism of the calcium signal and correlation with histamine release in 2H3 cells by Beaven, M A, Rogers, J, Moore, J P, Hesketh, T R, Smith, G A, Metcalfe, J C

“…Rat basophil leukemic (2H3) cells ( Siraganian , R.P., McGivney , A., Barsumian , E. L., Crews, F. T., Hirata , F., and Axelrod , J. (1982) Fed. Proc. 41,…”
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Free cytoplasmic calcium concentration and the mitogenic stimulation of lymphocytes by Hesketh, T R, Smith, G A, Moore, J P, Taylor, M V, Metcalfe, J C

“…The effects of the lectins concanavalin A, succinylated concanavalin A, and wheat germ agglutinin on the free cytoplasmic Ca2+ concentration in mouse…”
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The calcium signal and phosphatidylinositol breakdown in 2H3 cells by Beaven, M A, Moore, J P, Smith, G A, Hesketh, T R, Metcalfe, J C

“…Phosphatidylinositol (PI) and its phosphorylated derivatives are rapidly broken down in 2H3 cells stimulated with antigen, with a time course which coincides…”
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c-fos and c-myc gene activation, ionic signals, and DNA synthesis in thymocytes by Moore, J P, Todd, J A, Hesketh, T R, Metcalfe, J C

“…Among the earliest responses to mitogens that have been detected in normal quiescent cells are ionic changes: we have described rapid increases in the…”
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Synergistic Signals in the Mechanism of Antigen-Induced Exocytosis in 2H3 Cells: Evidence for an Unidentified Signal Required for Histamine Release by Beaven, Michael A., Guthrie, Denise F., Moore, John P., Smith, Gerry A., Hesketh, T. Robin, Metcalfe, James C.

“…The aim of this study was to determine whether the increase in cytosolic free Ca2+concentration ([ Ca2+]i) in response to antigen (aggregated ovalbumin) on…”
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The endothelin peptides ET-1, ET-2, ET-3 and sarafotoxin S6b are co-mitogenic with platelet-derived growth factor for vascular smooth muscle cells by Weissberg, P L, Witchell, C, Davenport, A P, Hesketh, T R, Metcalfe, J C

“…We have investigated whether any of the three isoforms of endothelin (ET) ET-1, ET-2 and ET-3 or the structurally similar peptide sarafotoxin S6b is mitogenic…”
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A common sequence of calcium and pH signals in the mitogenic stimulation of eukaryotic cells by HESKETH, T. R, MOORE, J. P, MORRIS, J. D. H, TAYLOR, M. V, ROGERS, J, SMITH, G. A, METCALFE, J. C

“…When normal quiescent (G0) cells are stimulated by mitogens to enter the cell cycle, the metabolic derepression which occurs is similar in a variety of cells…”
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A large accumulation of non-muscle myosin occurs at first entry into M phase in rat vascular smooth-muscle cells by GRAINGER, D. J, HESKETH, T. R, METCALFE, J. C, WEISSBERG, P. L

“…Vascular smooth-muscle cells (VSMCs) from rat aortae contained very little non-muscle myosin heavy chain (MHC) immediately after dispersal, and the protein did…”
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Hexamethylenebisacetamide selectively inhibits the proliferation of human and rat vascular smooth-muscle cells by GRAINGER, D. J, HESKETH, T. R, WEISSBERG, P. L, METCALFE, J. C

“…Hexamethylenebisacetamide (HMBA) selectively and reversibly inhibited proliferation of human and rat vascular smooth-muscle cells (VSMCs) compared with…”
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Mitogens increase phosphorylation of phosphoinositides in thymocytes by Taylor, Michael V, Metcalfe, James C, Hesketh, T. Robin, Smith, Gerry A, Moore, John P

“…In many cell systems the interaction of ligands with their receptors causes rapid breakdown and resynthesis of phosphatidylinositol 4,5-bisphosphate…”
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Calcium and cell proliferation by Metcalfe, J C, Moore, J P, Smith, G A, Hesketh, T R

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Calcium regulates inositol 1,3,4,5‐tetrakisphosphate production in lysed thymocytes and in intact cells stimulated with concanavalin A by Zilberman, Y., Howe, L.R., Moore, J.P., Hesketh, T.R., Metcalfe, J.C.

“…Lysed mouse thymocytes release [3H]inositol 1,4,5 trisphosphate from [3H]inositol‐labelled phosphatidyl inositol 4,5‐bisphosphate in response to GTP gamma S,…”
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Lymphocyte membrane potential assessed with fluorescent probes by Rink, T J, Montecucco, C, Hesketh, T R, Tsien, R Y

“…The membrane potential of mouse spleen lymphocytes has been assessed with two fluorescent probes. 3,3'-Dipropylthiadicarbocyanine (diS-C3-(5)) was used for…”
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Degenerate perturbations of protein structure as the mechanism of anaesthetic action by Richards, C. D, Martin, K, Gregory, S, Keightley, C. A, Hesketh, T. R, Smith, G. A, Warren, G. B, Metcalfe, J. C

“…The interaction of the n-alkanols with lipid bilayers and excitable membranes shows that there is no simple correlation between conduction block and any of the…”
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Annular lipids determine the ATPase activity of a calcium transport protein complexed with dipalmitoyllecithin by Hesketh, T. R, Smith, G. A, Houslay, M. D, McGill, K. A, Birdsall, N. J. M, Metcalfe, J. C, Warren, G. B

“…Pure complexes of dipalmitoyllecithin (DPL, 16:0) which Ca2+, Mg2+ dependent ATPase from sarcoplasmic reticulum are unusual in retaining significant ATPase…”
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Intracellular pH of stimulated thymocytes measured with a new fluorescent indicator by Rogers, J, Hesketh, T R, Smith, G A, Metcalfe, J C

“…A new fluorescent intracellular pH indicator is described ("quene 1") which is related to the tetracarboxylate Ca2+ indicator based on the quinoline fluorophor…”
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Stimulated Release of Histamine by a Rat Mast Cell Line Is Inhibited during Mitosis by Hesketh, T. Robin, Beaven, Michael A., Rogers, Jane, Burke, Brian, Warren, Graham B.

“…Stimulated histamine release was depressed at least tenfold in mitotic 2H3 rat basophilic cells when compared with interphase cells even though both contained…”
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Is an early calcium flux necessary to stimulate lymphocytes? by Hesketh, T. R, Smith, G. A, Houslay, M. D, Warren, G. B, Metcalfe, J. C

“…Concentrations of concanavalin A or the calcium ionophore A23187 that are optimal for the transformation of pig or mouse lymphocytes do not normally cause a…”
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Mitogen-stimulated activation of the Na+/H+ antiporter does not regulate S6 phosphorylation or protein synthesis in murine thymocytes or Swiss 3T3 fibroblasts by PENNINGTON, S. R, MOORE, J. P, HESKETH, T. R, METCALFE, J. C

“…The activation of protein synthesis by mitogens in quiescent (G0) mammalian cells is obligatory for progression from G0 through G1 to DNA synthesis in S phase…”
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