Search Results - "Hesbacher, Sonja"

IFN-gamma-induced PD-L1 expression in melanoma depends on p53 expression by Thiem, Alexander, Hesbacher, Sonja, Kneitz, Hermann, di Primio, Teresa, Heppt, Markus V, Hermanns, Heike M, Goebeler, Matthias, Meierjohann, Svenja, Houben, Roland, Schrama, David

“…Immune checkpoint inhibition and in particular anti-PD-1 immunotherapy have revolutionized the treatment of advanced melanoma. In this regard, higher tumoral…”
Get full text

Merkel Cell Polyomavirus Large T Antigen is Dispensable in G2 and M-Phase to Promote Proliferation of Merkel Cell Carcinoma Cells by Houben, Roland, Ebert, Marlies, Hesbacher, Sonja, Kervarrec, Thibault, Schrama, David

“…Merkel cell carcinoma (MCC) is an aggressive skin cancer frequently caused by the Merkel cell polyomavirus (MCPyV), and proliferation of MCPyV-positive MCC…”
Get full text

Elucidating the mechanism of action of domatinostat (4SC-202) in cutaneous T cell lymphoma cells by Wobser, Marion, Weber, Alexandra, Glunz, Amelie, Tauch, Saskia, Seitz, Kristina, Butelmann, Tobias, Hesbacher, Sonja, Goebeler, Matthias, Bartz, René, Kohlhof, Hella, Schrama, David, Houben, Roland

“…Targeting epigenetic modifiers is effective in cutaneous T cell lymphoma (CTCL). However, there is a need for further improvement of this therapeutic approach…”
Get full text

High-level expression of wild-type p53 in melanoma cells is frequently associated with inactivity in p53 reporter gene assays by Houben, Roland, Hesbacher, Sonja, Schmid, Corinna P, Kauczok, Claudia S, Flohr, Ulrike, Haferkamp, Sebastian, Müller, Cornelia S L, Schrama, David, Wischhusen, Jörg, Becker, Jürgen C

“…Inactivation of the p53 pathway that controls cell cycle progression, apoptosis and senescence, has been proposed to occur in virtually all human tumors and…”
Get full text

p53 regulation by TRP2 is not pervasive in melanoma by Houben, Roland, Schmid, Corinna P, Maier, Melissa, Wobser, Marion, Motschenbacher, Stephanie, Becker, Jürgen C, Vetter-Kauczok, Claudia S, Weyandt, Gerhard, Hesbacher, Sonja, Haferkamp, Sebastian

“…p53 is a central tumor suppressor protein and its inhibition is believed to be a prerequisite for cancer development. In approximately 50% of all malignancies…”
Get full text

Characterization of functional domains in the Merkel cell polyoma virus Large T antigen by Houben, Roland, Angermeyer, Sabrina, Haferkamp, Sebastian, Aue, Annemarie, Goebeler, Matthias, Schrama, David, Hesbacher, Sonja

“…Merkel cell polyomavirus (MCPyV)‐positive Merkel cell carcinoma (MCC) tumor cell growth is dependent on the expression of a viral Large T antigen (LT) with an…”
Get full text

RB1 is the crucial target of the Merkel cell polyomavirus Large T antigen in Merkel cell carcinoma cells by Hesbacher, Sonja, Pfitzer, Lisa, Wiedorfer, Katharina, Angermeyer, Sabrina, Borst, Andreas, Haferkamp, Sebastian, Scholz, Claus-Jürgen, Wobser, Marion, Schrama, David, Houben, Roland

“…The pocket protein (PP) family consists of the three members RB1, p107 and p130 all possessing tumor suppressive properties. Indeed, the PPs jointly control…”
Get full text

Inhibition of T-antigen expression promoting glycogen synthase kinase 3 impairs merkel cell carcinoma cell growth by Houben, Roland, Hesbacher, Sonja, Sarma, Bhavishya, Schulte, Carolin, Sarosi, Eva-Maria, Popp, Sabine, Adam, Christian, Kervarrec, Thibault, Schrama, David

“…Merkel cell carcinoma is an aggressive skin cancer frequently caused by the Merkel cell polyomavirus (MCPyV). Since proliferation of MCPyV-positive MCC tumor…”
Get full text

An intact retinoblastoma protein-binding site in Merkel cell polyomavirus large T antigen is required for promoting growth of Merkel cell carcinoma cells by Houben, Roland, Adam, Christian, Baeurle, Anne, Hesbacher, Sonja, Grimm, Johannes, Angermeyer, Sabrina, Henzel, Katharina, Hauser, Stefanie, Elling, Roland, Bröcker, Eva-B., Gaubatz, Stefan, Becker, Jürgen C., Schrama, David

“…Merkel cell carcinoma (MCC) is a highly aggressive skin cancer that frequently harbours Merkel cell polyomavirus (MCV) DNA integrated in the genome of the…”
Get full text

Mechanisms of p53 Restriction in Merkel Cell Carcinoma Cells Are Independent of the Merkel Cell Polyoma Virus T Antigens by Houben, Roland, Dreher, Christina, Angermeyer, Sabrina, Borst, Andreas, Utikal, Jochen, Haferkamp, Sebastian, Peitsch, Wiebke K., Schrama, David, Hesbacher, Sonja

“…Merkel cell carcinoma (MCC) is a rare and very aggressive skin cancer with viral etiology. The tumor-associated Merkel cell polyoma virus (MCV) belongs to a…”
Get full text

Serine 220 phosphorylation of the Merkel cell polyomavirus large T antigen crucially supports growth of Merkel cell carcinoma cells by Schrama, David, Hesbacher, Sonja, Angermeyer, Sabrina, Schlosser, Andreas, Haferkamp, Sebastian, Aue, Annemarie, Adam, Christian, Weber, Alexandra, Schmidt, Marc, Houben, Roland

“…Merkel cell polyomavirus (MCPyV) is regarded as a major causal factor for Merkel cell carcinoma (MCC). Indeed, tumor cell growth of MCPyV‐positive MCC cells is…”
Get full text

Merkel Cell Polyomavirus–Positive Merkel Cell Carcinoma Cells Do Not Require Expression of the Viral Small T Antigen by Angermeyer, Sabrina, Hesbacher, Sonja, Becker, Jürgen C., Schrama, David, Houben, Roland

“…Increasing evidence suggests that Merkel cell carcinoma (MCC) is caused by the Merkel cell polyomavirus (MCV). The viral sequence encodes for two potential…”
Get full text

4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2H-phenyl-1-phthalazinone Inhibits MCPyV T Antigen Expression in Merkel Cell Carcinoma Independent of Aurora Kinase A by Houben, Roland, Alimova, Pamela, Sarma, Bhavishya, Hesbacher, Sonja, Schulte, Carolin, Sarosi, Eva-Maria, Adam, Christian, Kervarrec, Thibault, Schrama, David

“…Merkel cell carcinoma (MCC) is frequently caused by the Merkel cell polyomavirus (MCPyV), and MCPyV-positive tumor cells depend on expression of the…”
Get full text

Recurrent FOXK1::GRHL and GPS2::GRHL fusions in trichogerminoma by Kervarrec, Thibault, Pissaloux, Daniel, Poilane, Jeremie, Tirode, Franck, Tallet, Anne, Collin, Christine, Tallegas, Matthias, Berthon, Patricia, Gaboriaud, Pauline, Sohier, Pierre, Calonje, Eduardo, Luzar, Boštjan, Goto, Keisuke, Cokelaere, Kristof, Lamant, Laurence, Balme, Brigitte, Wild, Richard, Neuville, Agnes, Deschamps, Lydia, Auberger, Elisabeth, Paumier, Veronique, Bonte, Helene, Moulonguet, Isabelle, Plantier, Françoise, Cales, Valérie, Pinsolle, Vincent, Roblet, Denis, Dupuy, Frantz, Dallot, Alexiane, Seris, Alice, Jouary, Thomas, Houben, Roland, Schrama, David, Hesbacher, Sonja, Macagno, Nicolas, Battistella, Maxime, Cribier, Bernard, Vergier, Beatrice, Fouchardière, Arnaud, Jullie, Marie‐Laure

“…We report 21 cases of trichogerminoma harbouring previously undescribed FOXK1::GRHL1/2 or GPS2::GRHL1/2/3 in‐frame fusion transcripts. Microscopic examination…”
Get full text

Combination with γ-secretase inhibitor prolongs treatment efficacy of BRAF inhibitor in BRAF-mutated melanoma cells by Zhu, Guannan, Yi, Xiuli, Haferkamp, Sebastian, Hesbacher, Sonja, Li, Chunying, Goebeler, Matthias, Gao, Tianwen, Houben, Roland, Schrama, David

“…Highlights • NOTCH activity protects melanonocytes from oncogene-induced senescence. • NOTCH pathway inhibitor enhances efficacy of BRAF-inhibitor treatment in…”
Get full text

Merkel Cell Polyomavirus T Antigens Induce Merkel Cell-Like Differentiation in GLI1-Expressing Epithelial Cells by Kervarrec, Thibault, Samimi, Mahtab, Hesbacher, Sonja, Berthon, Patricia, Wobser, Marion, Sallot, Aurélie, Sarma, Bhavishya, Schweinitzer, Sophie, Gandon, Théo, Destrieux, Christophe, Pasqualin, Côme, Guyétant, Serge, Touzé, Antoine, Houben, Roland, Schrama, David

“…Merkel cell carcinoma (MCC) is an aggressive skin cancer frequently caused by the Merkel cell polyomavirus (MCPyV). It is still under discussion, in which…”
Get full text

Characterization of functional domains in the M erkel cell polyoma virus L arge T antigen by Houben, Roland, Angermeyer, Sabrina, Haferkamp, Sebastian, Aue, Annemarie, Goebeler, Matthias, Schrama, David, Hesbacher, Sonja

“…Merkel cell polyomavirus (MCPyV)‐positive Merkel cell carcinoma (MCC) tumor cell growth is dependent on the expression of a viral Large T antigen (LT) with an…”
Get full text

Serine 220 phosphorylation of the M erkel cell polyomavirus large T antigen crucially supports growth of Merkel cell carcinoma cells by Schrama, David, Hesbacher, Sonja, Angermeyer, Sabrina, Schlosser, Andreas, Haferkamp, Sebastian, Aue, Annemarie, Adam, Christian, Weber, Alexandra, Schmidt, Marc, Houben, Roland

“…Merkel cell polyomavirus (MCPyV) is regarded as a major causal factor for Merkel cell carcinoma (MCC). Indeed, tumor cell growth of MCPyV‐positive MCC cells is…”
Get full text

Combination with [gamma]-secretase inhibitor prolongs treatment efficacy of BRAF inhibitor in BRAF-mutated melanoma cells by Zhu, Guannan, Yi, Xiuli, Haferkamp, Sebastian, Hesbacher, Sonja, Li, Chunying, Goebeler, Matthias, Gao, Tianwen, Houben, Roland, Schrama, David

“…Oncogenic triggering of the MAPK pathway in melanocytes results in senescence, and senescence escape is considered as one critical step for melanocytic…”
Get full text

Response to Shuda et al by Angermeyer, Sabrina, Hesbacher, Sonja, Becker, Jürgen C, Schrama, David, Houben, Roland

Get full text