Search Results - "Herzog, Sebastian"

Heparan sulfate proteoglycans serve as alternative receptors for low affinity LCMV variants by Volland, André, Lohmüller, Michael, Heilmann, Emmanuel, Kimpel, Janine, Herzog, Sebastian, von Laer, Dorothee

“…Members of the Old World Arenaviruses primarily utilize α-dystroglycan (α-DAG1) as a cellular receptor for infection. Mutations within the glycoprotein (GP) of…”
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Spontaneous termination of chaotic spiral wave dynamics in human cardiac ion channel models by Aron, Marcel, Herzog, Sebastian, Parlitz, Ulrich, Luther, Stefan, Lilienkamp, Thomas

“…Chaotic spiral or scroll wave dynamics can be found in diverse systems. In cardiac dynamics, spiral or scroll waves of electrical excitation determine the…”
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Generation of microRNA Sponge Library by Herzog, Sebastian

“…This protocol describes the generation and functional validation of microRNA (miRNA) sponge or decoy constructs. When expressed from a strong promoter, these…”
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Self-recognition and clonal selection: autoreactivity drives the generation of B cells by Herzog, Sebastian, Jumaa, Hassan

“…Highlights ► B cell receptor specificities are generated in a random process. ► Autoreactive specificities have been traditionally considered as harmful. ► New…”
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Elevational distribution and conservation biogeography of phanaeine dung beetles (Coleoptera: Scarabaeinae) in Bolivia by Herzog, Sebastian K, Hamel-Leigue, A Caroli, Larsen, Trond H, Mann, Darren J, Soria-Auza, Rodrigo W, Gill, Bruce D, Edmonds, W D, Spector, Sacha

“…Insect macroecology and conservation biogeography studies are disproportionately scarce, especially in the Neotropics. Dung beetles are an ideal focal taxon…”
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The prevalence, characteristics and effectiveness of Aichi Target 11′s “other effective area‐based conservation measures” (OECMs) in Key Biodiversity Areas by Donald, Paul F., Buchanan, Graeme M., Balmford, Andrew, Bingham, Heather, Couturier, Andrew R., la Rosa, Gregorio E., Gacheru, Paul, Herzog, Sebastian K., Jathar, Girish, Kingston, Naomi, Marnewick, Daniel, Maurer, Golo, Reaney, Leeann, Shmygaleva, Tatyana, Sklyarenko, Sergey, Stevens, Candice M.D., Butchart, Stuart H.M.

“…Aichi Target 11 of the CBD Strategic Plan for Biodiversity commits countries to the effective conservation of areas of importance for biodiversity, through…”
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The miR-15a/16-1 and miR-15b/16-2 clusters regulate early B cell development by limiting IL-7 receptor expression by Hutter, Katharina, Rülicke, Thomas, Szabo, Tamas G., Andersen, Lill, Villunger, Andreas, Herzog, Sebastian

“…MicroRNAs are small non-coding RNAs that have emerged as post-transcriptional regulators involved in development and function of different types of immune…”
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BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia by Hurtz, Christian, Hatzi, Katerina, Cerchietti, Leandro, Braig, Melanie, Park, Eugene, Kim, Yong-mi, Herzog, Sebastian, Ramezani-Rad, Parham, Jumaa, Hassan, Müller, Martin C, Hofmann, Wolf-Karsten, Hochhaus, Andreas, Ye, B Hilda, Agarwal, Anupriya, Druker, Brian J, Shah, Neil P, Melnick, Ari M, Müschen, Markus

“…Chronic myeloid leukemia (CML) is induced by the oncogenic BCR-ABL1 tyrosine kinase and can be effectively treated for many years with tyrosine kinase…”
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Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis by Schuler, Fabian, Weiss, Johannes G., Lindner, Silke E., Lohmüller, Michael, Herzog, Sebastian, Spiegl, Simon F., Menke, Philipp, Geley, Stephan, Labi, Verena, Villunger, Andreas

“…Checkpoint kinase 1 (CHK1) is critical for intrinsic cell cycle control and coordination of cell cycle progression in response to DNA damage. Despite its…”
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Data-Driven Modeling and Prediction of Complex Spatio-Temporal Dynamics in Excitable Media by Herzog, Sebastian, Wörgötter, Florentin, Parlitz, Ulrich

“…Spatio-temporal chaotic dynamics in a two-dimensional excitable medium is (cross-) estimated using a machine learning method based on a convolutional neural…”
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Efficient phenotypic sex classification of zebrafish using machine learning methods by Hosseini, Shahrbanou, Simianer, Henner, Tetens, Jens, Brenig, Bertram, Herzog, Sebastian, Sharifi, Ahmad Reza

“…Sex determination in zebrafish by manual approaches according to current guidelines relies on human observation. These guidelines for sex recognition have…”
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SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway by Jumaa, Hassan, Herzog, Sebastian, Hug, Eva, Meixlsperger, Sonja, Paik, Ji-Hye, DePinho, Ronald A, Reth, Michael

“…Although the essential role of the adaptor protein SLP-65 in pre-B cell differentiation is established, the molecular mechanism underlying its function is…”
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Genetic mechanism underlying sexual plasticity and its association with colour patterning in zebrafish (Danio rerio) by Hosseini, Shahrbanou, Ha, Ngoc-Thuy, Simianer, Henner, Falker-Gieske, Clemens, Brenig, Bertram, Franke, Andre, Hörstgen-Schwark, Gabriele, Tetens, Jens, Herzog, Sebastian, Sharifi, Ahmad Reza

“…Elevated water temperature, as is expected through climate change, leads to masculinization in fish species with sexual plasticity, resulting in changes in…”
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Impact of the quality of climate models for modelling species occurrences in countries with poor climatic documentation: a case study from Bolivia by Soria-Auza, Rodrigo W., Kessler, Michael, Bach, Kerstin, Barajas-Barbosa, Paola M., Lehnert, Marcus, Herzog, Sebastian K., Böhner, Jürgen

“…The quality of climate models has largely been overlooked as a possible source of uncertainty that may affect the outcomes of species distribution models,…”
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The SKP2‐p27 axis defines susceptibility to cell death upon CHK1 inhibition by Lohmüller, Michael, Roeck, Bernhard F., Szabo, Tamas G., Schapfl, Marina A., Pegka, Fragka, Herzog, Sebastian, Villunger, Andreas, Schuler, Fabian

“…Checkpoint kinase 1 (CHK1; encoded by CHEK1) is an essential gene that monitors DNA replication fidelity and prevents mitotic entry in the presence of…”
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Tutorial: a beginner’s guide to building a representative model of dynamical systems using the adjoint method by Lettermann, Leon, Jurado, Alejandro, Betz, Timo, Wörgötter, Florentin, Herzog, Sebastian

“…Building a representative model of a complex dynamical system from empirical evidence remains a highly challenging problem. Classically, these models are…”
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MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib by Young, Adelaide I J, Law, Andrew M K, Castillo, Lesley, Chong, Sabrina, Cullen, Hayley D, Koehler, Martin, Herzog, Sebastian, Brummer, Tilman, Lee, Erinna F, Fairlie, Walter D, Lucas, Morghan C, Herrmann, David, Allam, Amr, Timpson, Paul, Watkins, D Neil, Millar, Ewan K A, O'Toole, Sandra A, Gallego-Ortega, David, Ormandy, Christopher J, Oakes, Samantha R

“…Metastatic disease is largely resistant to therapy and accounts for almost all cancer deaths. Myeloid cell leukemia-1 (MCL-1) is an important regulator of cell…”
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Impact of Fires on Key Biodiversity Areas (KBAs) and Priority Bird Species for Conservation in Bolivia by Maillard, Oswaldo, Herzog, Sebastian K., Soria-Auza, Rodrigo W., Vides-Almonacid, Roberto

“…Key Biodiversity Areas (KBAs) are sites that contribute significantly to the protection of the planet’s biodiversity. In this study, we evaluated the annual…”
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A CRISPR screen in intestinal epithelial cells identifies novel factors for polarity and apical transport by Klee, Katharina M C, Hess, Michael W, Lohmüller, Michael, Herzog, Sebastian, Pfaller, Kristian, Müller, Thomas, Vogel, Georg F, Huber, Lukas A

“…Epithelial polarization and polarized cargo transport are highly coordinated and interdependent processes. In our search for novel regulators of epithelial…”
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Plant and animal endemism in the eastern Andean slope: challenges to conservation by Swenson, Jennifer J, Young, Bruce E, Beck, Stephan, Comer, Pat, Córdova, Jesús H, Dyson, Jessica, Embert, Dirk, Encarnación, Filomeno, Ferreira, Wanderley, Franke, Irma, Grossman, Dennis, Hernandez, Pilar, Herzog, Sebastian K, Josse, Carmen, Navarro, Gonzalo, Pacheco, Víctor, Stein, Bruce A, Timaná, Martín, Tovar, Antonio, Tovar, Carolina, Vargas, Julieta, Zambrana-Torrelio, Carlos M

“…BACKGROUND: The Andes-Amazon basin of Peru and Bolivia is one of the most data-poor, biologically rich, and rapidly changing areas of the world. Conservation…”
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