Search Results - "Herzog, Natalie"

HepG2-1A2 C2 and C7: Lentivirus vector-mediated stable and functional overexpression of cytochrome P450 1A2 in human hepatoblastoma cells by Steinbrecht, Susanne, Pfeifer, Nadine, Herzog, Natalie, Katzenberger, Nadine, Schulz, Christian, Kammerer, Sarah, Küpper, Jan-Heiner

“…Novel HepG2 cell clones 1A2 C2 and 1A2 C7 were independently generated by lentiviral transduction to functionally overexpress cytochrome P450 1A2 (CYP1A2). We…”
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Primary-like Human Hepatocytes Genetically Engineered to Obtain Proliferation Competence as a Capable Application for Energy Metabolism Experiments in In Vitro Oncologic Liver Models by Scheffschick, Andrea, Babel, Jonas, Sperling, Sebastian, Nerusch, Julia, Herzog, Natalie, Seehofer, Daniel, Damm, Georg

“…Non-alcoholic fatty liver disease (NAFLD), characterized by lipid accumulation in the liver, is the most common cause of liver diseases in Western countries…”
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Stable Chinese Hamster Ovary Suspension Cell Lines Harboring Recombinant Human Cytochrome P450 Oxidoreductase and Human Cytochrome P450 Monooxygenases as Platform for In Vitro Biotransformation Studies by Schulz, Christian, Herzog, Natalie, Kubick, Stefan, Jung, Friedrich, Küpper, Jan-Heiner

“…In the liver, phase-1 biotransformation of drugs and other xenobiotics is largely facilitated by enzyme complexes consisting of cytochrome P450 oxidoreductase…”
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Modeling atrial fibrosis in vitro—Generation and characterization of a novel human atrial fibroblast cell line by Künzel, Stephan R., Rausch, Johanna S. E., Schäffer, Charlotte, Hoffmann, Maximilian, Künzel, Karolina, Klapproth, Erik, Kant, Theresa, Herzog, Natalie, Küpper, Jan‐Heiner, Lorenz, Kristina, Dudek, Svenja, Emig, Ramona, Ravens, Ursula, Rog‐Zielinska, Eva A., Peyronnet, Rémi, El‐Armouche, Ali

“…Atrial fibrillation (AF) is regularly accompanied by cardiac fibrosis and concomitant heart failure. Due to the heterogeneous nature and complexity of…”
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Critical investigation on the usability of hepatoma cell lines HepG2 und Huh7 as models for the metabolic representation of resectable hepatocellular carcinoma by Scheffschick, Andrea, Schicht, Gerda, Seidemann, Lena, Sperling, Sebastian, Nerusch, Julia, Herzog, Natalie, Babel, Jonas, Küpper, Jan, Seehofer, Daniel, Damm, Georg

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Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation by Künzel, Stephan R., Hoffmann, Maximilian, Weber, Silvio, Künzel, Karolina, Kämmerer, Susanne, Günscht, Mario, Klapproth, Erik, Rausch, Johanna S.E., Sadek, Mirna S., Kolanowski, Tomasz, Meyer-Roxlau, Stefanie, Piorkowski, Christopher, Tugtekin, Sems M., Rose-John, Stefan, Yin, Xiaoke, Mayr, Manuel, Kuhlmann, Jan Dominik, Wimberger, Pauline, Grützmann, Konrad, Herzog, Natalie, Küpper, Jan-Heiner, O’Reilly, Molly, Kabir, S. Nashitha, Sommerfeld, Laura C., Guan, Kaomei, Wielockx, Ben, Fabritz, Larissa, Nattel, Stanley, Ravens, Ursula, Dobrev, Dobromir, Wagner, Michael, El-Armouche, Ali

“…[Figure: see text]…”
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Metabolic activity testing can underestimate acute drug cytotoxicity as revealed by HepG2 cell clones overexpressing cytochrome P450 2C19 and 3A4 by Steinbrecht, Susanne, König, Rosalie, Schmidtke, Kai-Uwe, Herzog, Natalie, Scheibner, Katrin, Krüger-Genge, Anne, Jung, Friedrich, Kammerer, Sarah, Küpper, Jan-Heiner

“…Preclinical drug safety assessment includes in vitro studies with physiologically relevant cell cultures. As an in vitro system for hepatic toxicology testing,…”
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Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation by Künzel, Stephan R., Hoffmann, Maximilian, Weber, Silvio, Künzel, Karolina, Kämmerer, Susanne, Günscht, Mario, Klapproth, Erik, Rausch, Johanna S. E., Sadek, Mirna S., Kolanowski, Tomasz, Meyer-Roxlau, Stefanie, Piorkowski, Christopher, Tugtekin, Sems M., Rose-John, Stefan, Yin, Xiaoke, Mayr, Manuel, Kuhlmann, Jan Dominik, Wimberger, Pauline, Grützmann, Konrad, Herzog, Natalie, Küpper, Jan-Heiner, O’Reilly, Molly, Kabir, S. Nashitha, Sommerfeld, Laura C., Guan, Kaomei, Wielockx, Ben, Fabritz, Larissa, Nattel, Stanley, Ravens, Ursula, Dobrev, Dobromir, Wagner, Michael, El-Armouche, Ali

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Primary-like human hepatocytes genetically engineered to obtain proliferation competence display hepatic differentiation characteristics in monolayer and organotypical spheroid cultures by Herzog, Natalie, Hansen, Max, Miethbauer, Sebastian, Schmidtke, Kai-Uwe, Anderer, Ursula, Lupp, Amelie, Sperling, Sebastian, Seehofer, Daniel, Damm, Georg, Scheibner, Katrin, Küpper, Jan-Heiner

“…Primary human hepatocytes are in great demand during drug development and in hepatology. However, both scarcity of tissue supply and donor variability of…”
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