Search Results - "Herzenberg, Leonard"

Linkage of inflammation and oxidative stress via release of glutathionylated peroxiredoxin-2, which acts as a danger signal by Salzano, Sonia, Checconi, Paola, Hanschmann, Eva-Maria, Lillig, Christopher Horst, Bowler, Lucas D., Chan, Philippe, Vaudry, David, Mengozzi, Manuela, Coppo, Lucia, Sacre, Sandra, Atkuri, Kondala R., Sahaf, Bita, Herzenberg, Leonard A., Herzenberg, Leonore A., Mullen, Lisa, Ghezzi, Pietro

“…The mechanism by which oxidative stress induces inflammation and vice versa is unclear but is of great importance, being apparently linked to many chronic…”
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Blastocyst complementation generates exogenic pancreas in vivo in apancreatic cloned pigs by Matsunari, Hitomi, Nagashima, Hiroshi, Watanabe, Masahito, Umeyama, Kazuhiro, Nakano, Kazuaki, Nagaya, Masaki, Kobayashi, Toshihiro, Yamaguchi, Tomoyuki, Sumazaki, Ryo, Herzenberg, Leonard A., Nakauchi, Hiromitsu

“…In the field of regenerative medicine, one of the ultimate goals is to generate functioning organs from pluripotent cells, such as ES cells or induced…”
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Two physically, functionally, and developmentally distinct peritoneal macrophage subsets by Ghosn, Eliver Eid Bou, Cassado, Alexandra A, Govoni, Gregory R, Fukuhara, Takeshi, Yang, Yang, Monack, Denise M, Bortoluci, Karina R, Almeida, Sandro R, Herzenberg, Leonard A, Herzenberg, Leonore A

“…The peritoneal cavity (PerC) is a unique compartment within which a variety of immune cells reside, and from which macrophages (MØ) are commonly drawn for…”
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N -Acetylcysteine—a safe antidote for cysteine/glutathione deficiency by Atkuri, Kondala R, Mantovani, John J, Herzenberg, Leonard A, Herzenberg, Leonore A

“…Glutathione (GSH) deficiency is associated with numerous pathological conditions. Administration of N -acetylcysteine (NAC), a cysteine prodrug, replenishes…”
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Interpreting flow cytometry data: a guide for the perplexed by Herzenberg, Leonore A, Tung, James, Moore, Wayne A, Herzenberg, Leonard A, Parks, David R

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Distinct progenitors for B-1 and B-2 cells are present in adult mouse spleen by Ghosn, Eliver Eid Bou, Sadate-Ngatchou, Patricia, Yang, Yang, Herzenberg, Leonard A, Herzenberg, Leonore A

“…Recent studies by Dorshkind, Yoder, and colleagues show that embryonic (E9) B-cell progenitors located in the yolk sac and intraembryonic hemogenic endothelium…”
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Distinct B-cell lineage commitment distinguishes adult bone marrow hematopoietic stem cells by Ghosn, Eliver Eid Bou, Yamamoto, Ryo, Hamanaka, Sanae, Yang, Yang, Herzenberg, Leonard A, Nakauchi, Hiromitsu, Herzenberg, Leonore A

“…The question of whether a single hematopoietic stem cell (HSC) gives rise to all of the B-cell subsets [B-1a, B-1b, B-2, and marginal zone (MZ) B cells] in the…”
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Glut1-mediated glucose transport regulates HIV infection by Loisel-Meyer, Séverine, Swainson, Louise, Craveiro, Marco, Oburoglu, Leal, Mongellaz, Cédric, Costa, Caroline, Martinez, Marion, Cosset, François-Loic, Battini, Jean-Luc, Herzenberg, Leonard A, Herzenberg, Leonore A, Atkuri, Kondala R, Sitbon, Marc, Kinet, Sandrina, Verhoeyen, Els, Taylor, Naomi

“…Cell cycle entry is commonly considered to positively regulate HIV-1 infection of CD4 T cells, raising the question as to how quiescent lymphocytes,…”
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High-Dose Oral N-Acetylcysteine, a Glutathione Prodrug, Modulates Inflammation in Cystic Fibrosis by Tirouvanziam, Rabindra, Conrad, Carol K., Bottiglieri, Teodoro, Herzenberg, Leonore A., Moss, Richard B., Herzenberg, Leonard A.

“…Neutrophilic airway inflammation is a hallmark of cystic fibrosis (CF). As high oxidant producers, airway neutrophils contribute largely to the systemic redox…”
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Importance of Culturing Primary Lymphocytes at Physiological Oxygen Levels by Atkuri, Kondala R., Herzenberg, Leonard A., Niemi, Anna-Kaisa, Cowan, Tina, Herzenberg, Leonore A.

“…Although studies with primary lymphocytes are almost always conducted in CO₂ incubators maintained at atmospheric oxygen levels (atmosO₂; 20%), the…”
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Utilization of Host SR Protein Kinases and RNA-Splicing Machinery during Viral Replication by Fukuhara, Takeshi, Hosoya, Takamitsu, Shimizu, Saki, Sumi, Kengo, Oshiro, Takako, Yoshinaka, Yoshiyuki, Suzuki, Masaaki, Yamamoto, Naoki, Herzenberg, Leonore A., Herzenberg, Leonard A., Hagiwara, Masatoshi

“…Although the viral genome is often quite small, it encodes a broad series of proteins. The virus takes advantage of the host-RNA-processing machinery to…”
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Antigen-specific memory in B-1a and its relationship to natural immunity by Yang, Yang, Ghosn, Eliver Eid Bou, Cole, Leah E, Obukhanych, Tetyana V, Sadate-Ngatchou, Patricia, Vogel, Stefanie N, Herzenberg, Leonard A, Herzenberg, Leonore A

“…In the companion article by Yang and colleagues [Yang Y, et al. (2012) Proc Natl Acad Sci USA, 109, 10.1073/pnas.1121631109], we have shown that priming with…”
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Division and differentiation of natural antibody-producing cells in mouse spleen by Yang, Yang, Tung, James W, Ghosn, Eliver E.B, Herzenberg, Leonard A, Herzenberg, Leonore A

“…B-1a cells reside in both the peritoneal cavity and the spleen. LPS stimulates splenic B-1a to differentiate to plasma cells producing natural IgM specific for…”
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Profound functional and signaling changes in viable inflammatory neutrophils homing to cystic fibrosis airways by Tirouvanziam, Rabindra, Gernez, Yael, Conrad, Carol K, Moss, Richard B, Schrijver, Iris, Dunn, Colleen E, Davies, Zoe A, Herzenberg, Leonore A, Herzenberg, Leonard A

“…Blood neutrophils recruited to cystic fibrosis (CF) airways are believed to be rapidly killed by resident bacteria and to passively release elastase and other…”
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The History and Future of the Fluorescence Activated Cell Sorter and Flow Cytometry: A View from Stanford by Herzenberg, Leonard A, Parks, David, Sahaf, Bita, Perez, Omar, Roederer, Mario, Herzenberg, Leonore A

“…The Fluorescence Activated Cell Sorter (FACS) was invented in the late 1960s by Bonner, Sweet, Hulett, Herzenberg, and others to do flow cytometry and cell…”
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Inherited disorders affecting mitochondrial function are associated with glutathione deficiency and hypocitrullinemia by Atkuri, Kondala R, Cowan, Tina M, Kwan, Tony, Ng, Angelina, Herzenberg, Leonard A, Herzenberg, Leonore A, Enns, Gregory M

“…Disorders affecting mitochondria, including those that directly affect the respiratory chain function or result from abnormalities in branched amino acid…”
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Modern Flow Cytometry: A Practical Approach by Tung, James W., MD, PhD, Heydari, Kartoosh, MD, Tirouvanziam, Rabin, PhD, Sahaf, Bita, Parks, David R., PhD, Herzenberg, Leonard A., PhD, Herzenberg, Leonore A., MD, PhD

“…The demonstration that CD T-cell counts can be used to monitor HIV disease progression opened the way to the first clinical application for fluorescence…”
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H–Y antigen-binding B cells develop in male recipients of female hematopoietic cells and associate with chronic graft vs. host disease by Sahaf, Bita, Yang, Yang, Arai, Sally, Herzenberg, Leonard A., Herzenberg, Leonore A., Miklos, David B.

“…B cells are known to play an important role in pathogenesis of human chronic graft vs. host disease (cGVHD). Our group has previously shown that IgG…”
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Reversal of paralysis and reduced inflammation from peripheral administration of β-amyloid in TH1 and TH17 versions of experimental autoimmune encephalomyelitis by Grant, Jacqueline L, Ghosn, Eliver Eid Bou, Axtell, Robert C, Herges, Katja, Kuipers, Hedwich F, Woodling, Nathan S, Andreasson, Katrin, Herzenberg, Leonard A, Herzenberg, Leonore A, Steinman, Lawrence

“…β-Amyloid 42 (Aβ42) and β-amyloid 40 (Aβ40), major components of senile plaque deposits in Alzheimer's disease, are considered neurotoxic and proinflammatory…”
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Antigen-specific antibody responses in B-1a and their relationship to natural immunity by Yang, Yang, Ghosn, Eliver Eid Bou, Cole, Leah E, Obukhanych, Tetyana V, Sadate-Ngatchou, Patricia, Vogel, Stefanie N, Herzenberg, Leonard A, Herzenberg, Leonore A

“…B-1a cells are primarily thought of as natural antibody-producing cells. However, we now show that appropriate antigenic stimulation induces IgM and IgG B-1a…”
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