Search Results - "Herweijer, Hans"

A Facile Nonviral Method for Delivering Genes and siRNAs to Skeletal Muscle of Mammalian Limbs by Hagstrom, James E, Hegge, Julia, Zhang, Guofeng, Noble, Mark, Budker, Vladimir, Lewis, David L, Herweijer, Hans, Wolff, Jon A

“…Delivery is increasingly being recognized as the critical hurdle holding back the tremendous promise of nucleic acid-based therapies that include gene therapy…”
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Sustained liver-specific transgene expression from the albumin promoter in mice following hydrodynamic plasmid DNA delivery by Wooddell, Christine I., Reppen, Thomas, Wolff, Jon A., Herweijer, Hans

“…Background To properly study gene expression in vivo, often long‐term expression is desired. Previous studies using plasmid DNA (pDNA) vectors have typically…”
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Transcriptional and phenotypic comparisons of Ppara knockout and siRNA knockdown mice by De Souza, Angus T, Dai, Xudong, Spencer, Andrew G, Reppen, Tom, Menzie, Ann, Roesch, Paula L, He, Yudong, Caguyong, Michelle J, Bloomer, Sherri, Herweijer, Hans, Wolff, Jon A, Hagstrom, James E, Lewis, David L, Linsley, Peter S, Ulrich, Roger G

“…RNA interference (RNAi) has great potential as a tool for studying gene function in mammals. However, the specificity and magnitude of the in vivo response to…”
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Targeted siRNA Delivery and mRNA Knockdown Mediated by Bispecific Digoxigenin-binding Antibodies by Schneider, Britta, Grote, Michael, John, Matthias, Haas, Alexander, Bramlage, Birgit, lckenstein, Ludger M, Jahn-Hofmann, Kerstin, Bauss, Frieder, Cheng, Weijun, Croasdale, Rebecca, Daub, Karin, Dill, Simone, Hoffmann, Eike, Lau, Wilma, Burtscher, Helmut, Ludtke, James L, Metz, Silke, Mundigl, Olaf, Neal, Zane C, Scheuer, Werner, Stracke, Jan, Herweijer, Hans, Brinkmann, Ulrjch

“…Bispecific antibodies (bsAbs) that bind to cell surface antigens and to digoxigenin (Dig) were used for targeted small interfering RNA (siRNA) delivery. They…”
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Long-term RNA interference from optimized siRNA expression constructs in adult mice by Wooddell, Christine I., Van Hout, Cristopher V., Reppen, Thomas, Lewis, David L., Herweijer, Hans

“…DNA constructs for small interfering RNA (siRNA) expression in mammalian cells have the potential for longer-term target gene knockdown than synthetic siRNAs…”
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Genetic immunization for antibody generation in research animals by intravenous delivery of plasmid DNA by Bates, Mary Kay, Zhang, Guofeng, Sebestyén, Magdolna G, Neal, Zane C, Wolff, Jon A, Herweijer, Hans

“…Genetic immunization is an attractive approach to generate antibodies because native proteins are expressed in vivo with normal posttranscriptional…”
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Time course of gene expression after plasmid DNA gene transfer to the liver by Herweijer, Hans, Zhang, Guofeng, Subbotin, Vladimir M., Budker, Vladimir, Williams, Phillip, Wolff, Jon A.

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Combined radiation and p53 gene therapy of malignant glioma cells by Badie, B, Goh, C S, Klaver, J, Herweijer, H, Boothman, D A

“…More than half of malignant gliomas reportedly have alterations in the p53 tumor suppressor gene. Because p53 plays a key role in the cellular response to…”
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PPARalpha siRNA-treated expression profiles uncover the causal sufficiency network for compound-induced liver hypertrophy by Dai, Xudong, De Souza, Angus T, Dai, Hongyue, Lewis, David L, Lee, Chang-kyu, Spencer, Andy G, Herweijer, Hans, Hagstrom, Jim E, Linsley, Peter S, Bassett, Douglas E, Ulrich, Roger G, He, Yudong D

“…Uncovering pathways underlying drug-induced toxicity is a fundamental objective in the field of toxicogenomics. Developing mechanism-based toxicity biomarkers…”
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Efficient delivery of siRNA for inhibition of gene expression in postnatal mice by Lewis, David L, Hagstrom, James E, Loomis, Aaron G, Wolff, Jon A, Herweijer, Hans

“…It has recently been shown that RNA interference can be induced in cultured mammalian cells by delivery of short interfering RNAs (siRNAs). Here we describe a…”
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Progress toward a nonviral gene therapy protocol for the treatment of anemia by Sebestyén, Magdolna G, Hegge, Julia O, Noble, Mark A, Lewis, David L, Herweijer, Hans, Wolff, Jon A

“…Anemia frequently accompanies chronic diseases such as progressive renal failure, acquired immunodeficiency syndrome, and cancer. Patients are currently…”
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Dose response in rodents and nonhuman primates after hydrodynamic limb vein delivery of naked plasmid DNA by Wooddell, Christine I, Hegge, Julia O, Zhang, Guofeng, Sebestyén, Magdolna G, Noble, Mark, Griffin, Jacob B, Pfannes, Loretta V, Herweijer, Hans, Hagstrom, James E, Braun, Serge, Huss, Thierry, Wolff, Jon A

“…The efficacy of gene therapy mediated by plasmid DNA (pDNA) depends on the selection of suitable vectors and doses. Using hydrodynamic limb vein (HLV)…”
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Intraarterial delivery of naked plasmid DNA expressing full-length mouse dystrophin in the mdx mouse model of duchenne muscular dystrophy by Zhang, Goufeng, Ludtke, James J, Thioudellet, Christine, Kleinpeter, Patricia, Antoniou, Michael, Herweijer, Hans, Braun, Serge, Wolff, Jon A

“…Our previous studies have demonstrated that the intraarterial delivery of naked plasmid DNA leads to high levels of foreign gene expression throughout the…”
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Hydrodynamic Limb Vein Delivery of a Xenogeneic DNA Cancer Vaccine Effectively Induces Antitumor Immunity by Neal, Zane C, Bates, Mary K, Albertini, Mark R, Herweijer, Hans

“…Tumor-associated antigens (TAA) are typically poorly immunogenic “self” antigens. An effective strategy to break tolerance and induce antitumor immunity is by…”
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Rapid Intravascular Injection into Limb Skeletal Muscle: A Damage Assessment Study by Toumi, Hechmi, Hegge, Julia, Subbotin, Vladimir, Noble, Mark, Herweijer, Hans, Best, Thomas M, Hagstrom, James E

“…We have recently developed a simple and highly efficient methodology for delivering plasmid DNA (pDNA) to skeletal muscle cells of mammalian limbs. The…”
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Time course of gene expression after plasmid DNA gene transfer to the liver by Herweijer, Hans, Zhang, Guofeng, Subbotin, Vladimir M., Budker, Vladimir, Williams, Phillip, Wolff, Jon A.

“…Background High levels of expression in hepatocytes can be achieved after intraportal delivery of plasmid DNA vectors with up to 10% of all liver cells…”
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Flt3-L gene therapy enhances immunocytokine-mediated antitumor effects and induces long-term memory by Neal, Zane C, Sondel, Paul M, Bates, Mary Kay, Gillies, Stephen D, Herweijer, Hans

“…Therapeutic treatment with hu14.18-IL-2 immunocytokine (IC) or Flt3-L (FL) protein is initially effective at resolving established intradermal NXS2…”
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Gene transfer into mammalian cells using histone-condensed plasmid DNA by Fritz, J D, Herweijer, H, Zhang, G, Wolff, J A

“…A recombinant histone (NLS-H1) containing both the SV40 large T antigen nuclear localization signal and the carboxy-terminal domain of human histone H1(0) was…”
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Dramatic Expansion of Mature Dendritic Cells by Sequential Gene Therapy by Neal, Zane C, Bates, Mary Kay, Herweijer, Hans

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Hydrodynamic Limb Vein-Delivered Xenogeneic DNA Cancer Vaccine Effectively Induces Antitumor Protection by Neal, Zane C, Bates, Mary Kay, Herweijer, Hans

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