Search Results - "Hervas, Ruben"

Organic matter interference with steroid hormone removal by single-walled carbon nanotubes − ultrafiltration composite membrane by Nguyen, Minh Nhat, Hérvas-Martínez, Rubén, Schäfer, Andrea Iris

“…•Hormone removal by carbon nanotube−ultrafiltration composites is evaluated•Different organic matter types impact hormone adsorption to specific…”
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Integrated regulation of tubulin tyrosination and microtubule stability by human α-tubulin isotypes by Fu, Guoling, Yan, Shan, Khoo, Chen Jing, Chao, Victor C., Liu, Zheng, Mukhi, Mayur, Hervas, Rubén, Li, Xiang David, Ti, Shih-Chieh

“…Tubulin isotypes are critical for the functions of cellular microtubules, which exhibit different stability and harbor various post-translational…”
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Cryo-EM structure of a neuronal functional amyloid implicated in memory persistence in Drosophila by Hervas, Ruben, Rau, Michael J, Park, Younshim, Zhang, Wenjuan, Murzin, Alexey G, Fitzpatrick, James A J, Scheres, Sjors H W, Si, Kausik

“…How long-lived memories withstand molecular turnover is a fundamental question. Aggregates of a prion-like RNA-binding protein, cytoplasmic polyadenylation…”
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Mechanistic Insights into the Role of Molecular Chaperones in Protein Misfolding Diseases: From Molecular Recognition to Amyloid Disassembly by Hervás, Rubén, Oroz, Javier

“…Age-dependent alterations in the proteostasis network are crucial in the progress of prevalent neurodegenerative diseases, such as Alzheimer's, Parkinson's, or…”
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Metamorphism in TDP-43 prion-like domain determines chaperone recognition by Carrasco, Jaime, Antón, Rosa, Valbuena, Alejandro, Pantoja-Uceda, David, Mukhi, Mayur, Hervás, Rubén, Laurents, Douglas V., Gasset, María, Oroz, Javier

“…The RNA binding protein TDP-43 forms cytoplasmic inclusions via its C-terminal prion-like domain in several neurodegenerative diseases. Aberrant TDP-43…”
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Implications of the Orb2 Amyloid Structure in Huntington's Disease by Hervás, Rubén, Murzin, Alexey G, Si, Kausik

“…Huntington's disease is a progressive, autosomal dominant, neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. As a result, the…”
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Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-β-Induced Neuronal Death by Fernandez, Ana M, Hervas, Ruben, Dominguez-Fraile, Manuel, Garrido, Victoria Navarro, Gomez-Gutierrez, Patricia, Vega, Miguel, Vitorica, Javier, Perez, Juan J, Torres Aleman, Ignacio

“…Astrocytes actively participate in neuro-inflammatory processes associated to Alzheimer's disease (AD), and other brain pathologies. We recently showed that an…”
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Structural Evidence of Amyloid Fibril Formation in the Putative Aggregation Domain of TDP-43 by Mompeán, Miguel, Hervás, Rubén, Xu, Yunyao, Tran, Timothy H, Guarnaccia, Corrado, Buratti, Emanuele, Baralle, Francisco, Tong, Liang, Carrión-Vázquez, Mariano, McDermott, Ann E, Laurents, Douglas V

“…TDP-43 can form pathological proteinaceous aggregates linked to ALS and FTLD. Within the putative aggregation domain, engineered repeats of residues 341–366…”
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Phase separation modulates the functional amyloid assembly of human CPEB3 by Ramírez de Mingo, Daniel, López-García, Paula, Vaquero, María Eugenia, Hervás, Rubén, Laurents, Douglas V, Carrión-Vázquez, Mariano

“…How functional amyloids are regulated to restrict their activity is poorly understood. The cytoplasmic polyadenylation element-binding protein 3 (CPEB3) is an…”
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Divergent CPEB prion-like domains reveal different assembly mechanisms for a generic amyloid-like fold by Hervás, Rubén, Del Carmen Fernández-Ramírez, María, Galera-Prat, Albert, Suzuki, Mari, Nagai, Yoshitaka, Bruix, Marta, Menéndez, Margarita, Laurents, Douglas V, Carrión-Vázquez, Mariano

“…Amyloids are ordered, insoluble protein aggregates, characterized by a cross-β sheet quaternary structure in which molecules in a β-strand conformation are…”
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Molecular mechanism of the inhibition of TDP-43 amyloidogenesis by QBP1 by Mompeán, Miguel, Ramírez de Mingo, Daniel, Hervás, Rubén, Fernández-Ramírez, María del Carmen, Carrión-Vázquez, Mariano, Laurents, Douglas V.

“…Transactive Response DNA-Binding Protein of 43 kDa (TDP-43) is an essential human protein implicated in Amyotrophic Lateral Sclerosis (ALS) and common…”
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Molecular Basis of Orb2 Amyloidogenesis and Blockade of Memory Consolidation by Hervás, Rubén, Li, Liying, Majumdar, Amitabha, Fernández-Ramírez, María Del Carmen, Unruh, Jay R, Slaughter, Brian D, Galera-Prat, Albert, Santana, Elena, Suzuki, Mari, Nagai, Yoshitaka, Bruix, Marta, Casas-Tintó, Sergio, Menéndez, Margarita, Laurents, Douglas V, Si, Kausik, Carrión-Vázquez, Mariano

“…Amyloids are ordered protein aggregates that are typically associated with neurodegenerative diseases and cognitive impairment. By contrast, the amyloid-like…”
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Nanomechanics of tip-link cadherins by Oroz, Javier, Galera-Prat, Albert, Hervás, Rubén, Valbuena, Alejandro, Fernández-Bravo, Débora, Carrión-Vázquez, Mariano

“…Hearing and balance rely on the transduction of mechanical stimuli arising from sound waves or head movements into electrochemical signals. This archetypal…”
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Expanded Conformations of Monomeric Tau Initiate Its Amyloidogenesis by Fernández‐Ramírez, María del Carmen, Ng, Kevin Kan‐Shing, Menéndez, Margarita, Laurents, Douglas V., Hervás, Rubén, Carrión‐Vázquez, Mariano

“…Understanding early amyloidogenesis is key to rationally develop therapeutic strategies. Tau protein forms well‐characterized pathological deposits but its…”
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On the remarkable mechanostability of scaffoldins and the mechanical clamp motif by Valbuena, Alejandro, Oroz, Javier, Hervás, Rubén, Vera, Andrés Manuel, Rodríguez, David, Menéndez, Margarita, Sulkowska, Joanna I, Cieplak, Marek, Carrión-Vázquez, Mariano

“…Protein mechanostability is a fundamental biological property that can only be measured by single-molecule manipulation techniques. Such studies have unveiled…”
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Amyloid-like Assembly Activates a Phosphatase in the Developing Drosophila Embryo by Nil, Zelha, Hervás, Rubén, Gerbich, Therese, Leal, Paulo, Yu, Zulin, Saraf, Anita, Sardiu, Mihaela, Lange, Jeffrey J., Yi, Kexi, Unruh, Jay, Slaughter, Brian, Si, Kausik

“…Prion-like proteins can assume distinct conformational and physical states in the same cell. Sequence analysis suggests that prion-like proteins are prevalent…”
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Amyloid-like Assembly Activates a Phosphatase in the Developing Drosophila Embryo by Nil, Zelha, Hervás, Rubén, Gerbich, Therese, Leal, Paulo, Yu, Zulin, Saraf, Anita, Sardiu, Mihaela, Lange, Jeffrey J., Yi, Kexi, Unruh, Jay, Slaughter, Brian, Si, Kausik

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Efficient and simplified nanomechanical analysis of intrinsically disordered proteins by Fernández-Ramírez, María Del Carmen, Hervás, Rubén, Galera-Prat, Albert, Laurents, Douglas V, Carrión-Vázquez, Mariano

“…Intrinsically disordered proteins (IDPs) lack a tertiary structure. Amyloidogenic IDPs (aIDPs) in particular have attracted great interest due to their…”
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Common features at the start of the neurodegeneration cascade by Hervás, Rubén, Oroz, Javier, Galera-Prat, Albert, Goñi, Oscar, Valbuena, Alejandro, Vera, Andrés M, Gómez-Sicilia, Angel, Losada-Urzáiz, Fernando, Uversky, Vladimir N, Menéndez, Margarita, Laurents, Douglas V, Bruix, Marta, Carrión-Vázquez, Mariano

“…Amyloidogenic neurodegenerative diseases are incurable conditions with high social impact that are typically caused by specific, largely disordered proteins…”
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Unequivocal Single-Molecule Force Spectroscopy of Proteins by AFM Using pFS Vectors by Oroz, Javier, Hervás, Rubén, Carrión-Vázquez, Mariano

“…Nanomechanical analysis of proteins by single-molecule force spectroscopy based on atomic force microscopy is increasingly being used to investigate the inner…”
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