Search Results - "Hertzberg, Robert P."

Impact of high-throughput screening in biomedical research by Macarron, Ricardo, Banks, Martyn N, Bojanic, Dejan, Burns, David J, Cirovic, Dragan A, Garyantes, Tina, Green, Darren V. S, Hertzberg, Robert P, Janzen, William P, Paslay, Jeff W, Schopfer, Ulrich, Sittampalam, G. Sitta

“…Has high-throughput screening (HTS) been unfairly blamed one factor responsible for the decline in productivity in the pharmaceutical industry? This article…”
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High-throughput screening: new technology for the 21st century by Hertzberg, Robert P, Pope, Andrew J

“…New technologies in high-throughput screening have significantly increased throughput and reduced assay volumes. Key advances over the past few years include…”
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Evaluation of Potent and Selective Small-Molecule Antagonists for the CXCR2 Chemokine Receptor by Widdowson, Katherine L, Elliott, John D, Veber, Daniel F, Nie, Hong, Rutledge, Melvin C, McCleland, Brent W, Xiang, Jia-Ning, Jurewicz, Anthony J, Hertzberg, Robert P, Foley, James J, Griswold, Don E, Martin, Lenox, Lee, Judithann M, White, John R, Sarau, Henry M

“…N,N‘-Diarylureas were prepared, and the structure−activity relationship relative to the CXCR2 receptor was examined. This led to the identification of a potent…”
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Design and Implementation of High Throughput Screening Assays by Macarrón, Ricardo, Hertzberg, Robert P

“…High throughput screening (HTS) is at the core of the drug discovery process, and so it is critical to design and implement HTS assays in a comprehensive…”
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Design and Implementation of High-Throughput Screening Assays by Powell, David J, Hertzberg, Robert P, Macarrόn, Ricardo

“…HTS remains at the core of the drug discovery process, and so it is critical to design and implement HTS assays in a comprehensive fashion involving scientists…”
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On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex by Hertzberg, Robert P, Caranfa, Mary Jo, Hecht, Sidney M

“…Camptothecin, a cytotoxic antitumor compound, has been shown to produce protein-linked DNA breaks mediated by mammalian topoisomerase I. We have investigated…”
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Synthesis of water-soluble (aminoalkyl)camptothecin analogs: inhibition of topoisomerase I and antitumor activity by Kingsbury, William D, Boehm, Jeffrey C, Jakas, Dalia R, Holden, Kenneth G, Hecht, Sidney M, Gallagher, Gregory, Caranfa, Mary Jo, McCabe, Francis L, Faucette, Leo F, Johnson, Randall K, Hertzberg, Robert P

“…Water-soluble analogues of the antitumor alkaloid camptothecin (1) were prepared in which aminoalkyl groups were introduced into ring A or B. Most of the…”
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Design and implementation of high-throughput screening assays by Macarrón, Ricardo, Hertzberg, Robert P

“…HTS is at the core of the drug discovery process, and so it is critical to design and implement HTS assays in a comprehensive fashion involving scientists from…”
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Identification of a Potent, Selective Non-peptide CXCR2 Antagonist That Inhibits Interleukin-8-induced Neutrophil Migration by White, John R., Lee, Judithann M., Young, Peter R., Hertzberg, Robert P., Jurewicz, Anthony J., Chaikin, Margery A., Widdowson, Katherine, Foley, James J., Martin, Lenox D., Griswold, Don E., Sarau, Henry M.

“…Interleukin-8 (IL-8) and closely related Glu-Leu-Arg (ELR) containing CXC chemokines, including growth-related oncogene (GRO)α, GROβ, GROγ, and epithelial…”
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Design and implementation of high throughput screening assays by Macarrón, Ricardo, Hertzberg, Robert P

“…HTS is at the core of the drug-discovery process, and so it is critical to design and implement HTS assays in a comprehensive fashion involving scientists from…”
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Molecular Cloning and Characterization of the Human Anaphylatoxin C3a Receptor by Ames, Robert S., Li, Yi, Sarau, Henry M., Nuthulaganti, Paru, Foley, James J., Ellis, Catherine, Zeng, Zhizhen, Su, Kui, Jurewicz, Anthony J., Hertzberg, Robert P., Bergsma, Derk J., Kumar, Chandrika

“…In a human neutrophil cDNA library, an orphan G-protein-coupled receptor, HNFAG09, with 37% nucleotide identity to the C5a receptor (C5a-R, CD88) was…”
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A standard operating procedure for assessing liquid handler performance in high-throughput screening by Taylor, Paul B, Ashman, Stephen, Baddeley, Stuart M, Bartram, Stacy L, Battle, Clive D, Bond, Brian C, Clements, Yvonne M, Gaul, Nathan J, McAllister, W Elliot, Mostacero, Juan A, Ramon, Fernando, Wilson, Jamie M, Hertzberg, Robert P, Pope, Andrew J, Macarron, Ricardo

“…The thrust of early drug discovery in recent years has been toward the configuration of homogeneous miniaturized assays. This has allowed organizations to…”
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Cleavage of DNA with methidiumpropyl-EDTA-iron(II): reaction conditions and product analyses by Hertzberg, Robert P, Dervan, Peter B

“…The synthesis of methidiumpropyl-EDTA (MPE) is described. The binding affinities of MPE, MPE.Ni(II), and MPE.Mg(II) to calf thymus DNA are 2.4 X 10(4) M-1, 1.5…”
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In vitro and intracellular inhibition of topoisomerase II by the antitumor agent merbarone by DRAKE, F. H, HOFMANN, G. A, SHAU-MING MONG, O'LEARY BARTUS, J, HERTZBERG, R. P, JOHNSON, R. K, MATTERN, M. R, MIRABELLI, C. K

“…Merbarone has previously been shown to have antitumor activity of unknown mechanism in P388 and L1210 tumor models (A. D. Brewer et al., Biochem. Pharmacol.,…”
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Automated assay optimization with integrated statistics and smart robotics by Taylor, P B, Stewart, F P, Dunnington, D J, Quinn, S T, Schulz, C K, Vaidya, K S, Kurali, E, Lane, T R, Xiong, W C, Sherrill, T P, Snider, J S, Terpstra, N D, Hertzberg, R P

“…The transition from manual to robotic high throughput screening (HTS) in the last few years has made it feasible to screen hundreds of thousands of chemical…”
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Camptothecin-resistant mutants of chinese hamster ovary cells containing a resistant form of topoisomerase I by GUPTA, R. S, GUPTA, R, ENG, B, LOCK, R. B, ROSS, W. E, HERTZBERG, R. P, CARANFA, M. J, JOHNSON, R. K

“…In Chinese hamster ovary cells, stable mutants that exhibit 250- to 350-fold resistance to camptothecin (CptR mutants) have been isolated from mutagen-treated…”
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Pyrrolo[1,4]benzodiazepine antitumor antibiotics: relationship of DNA alkylation and sequence specificity to the biological activity of natural and synthetic compounds by Hurley, Laurence H, Reck, Teri, Thurston, David E, Langley, David R, Holden, Kenneth G, Hertzberg, Robert P, Hoover, John R. E, Gallagher, Gregory, Faucette, Leo F

“…The DNA alkylation and sequence specificity of a group of natural and synthetic pyrrolo-[1,4]benzodiazepines [P(1,4)Bs] were evaluated by using an exonuclease…”
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DNA sequence specificity of the pyrrolo[1,4]benzodiazepine antitumor antibiotics. Methidiumpropyl-EDTA-iron(II) footprinting analysis of DNA binding sites for anthramycin and related drugs by Hertzberg, Robert P, Hecht, Sidney M, Reynolds, Vincent L, Molineux, Ian J, Hurley, Laurence H

“…Anthramycin, tomaymycin, and sibiromycin are members of the pyrrolo[1,4]benzodiazepine [P(1,4)B] antitumor antibiotic group. These drugs bind covalently…”
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The role of the anionic groups in the receptor binding of interleukin-8 antagonists by Widdowson, Katherine, Nie, Hong, Jurewicz, Anthony J, Hertzberg, Robert P, Sarau, Henry M, Foley, James J, Lee, JudithAnn, White, John R, Veber, Daniel F

“…SummaryIn an effort to determine the role of the acidic group in the receptor binding ofN-(2-hydroxy-4-nitrophenyl)-N′-(phenyl) urea, an interleukin-8B…”
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Degradation of structurally modified DNAs by bleomycin group antibiotics by Hertzberg, Robert P, Caranfa, Mary Jo, Hecht, Sidney M

“…Bleomycin-mediated DNA strand scission has been shown to be diminished at certain sequences in proximity to 5-methylcytidines. We have investigated the…”
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