Search Results - "Hertzberg, Richard"

Benchmark dose (BMD) modeling: current practice, issues, and challenges by Haber, Lynne T., Dourson, Michael L., Allen, Bruce C., Hertzberg, Richard C., Parker, Ann, Vincent, Melissa J., Maier, Andrew, Boobis, Alan R.

“…Benchmark dose (BMD) modeling is now the state of the science for determining the point of departure for risk assessment. Key advantages include the fact that…”
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In Memoriam: Jane Ellen Simmons by Rider, Cynthia V, Birnbaum, Linda S, DeVito, Michael J, Hertzberg, Richard C, Rice, Glenn E, Teuschler, Linda K

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Evaluation of a Proportional Response Addition Approach to Mixture Risk Assessment and Predictive Toxicology Using Data on Four Trihalomethanes from the U.S. EPA's Multiple-Purpose Design Study by Teuschler, Linda K, Hertzberg, Richard C, McDonald, Anthony, Sey, Yusupha Mahtarr, Simmons, Jane Ellen

“…In this study, proportional response addition (Prop-RA), a model for predicting response from chemical mixture exposure, is demonstrated and evaluated by…”
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Evaluation of the Interaction-Based Hazard Index Formula Using Data on Four Trihalomethanes from U.S. EPA's Multiple-Purpose Design Study by Hertzberg, Richard C, Teuschler, Linda K, McDonald, Anthony, Sey, Yusupha Mahtarr, Simmons, Jane Ellen

“…The interaction-based hazard index (HI ), a mixtures approach to characterizing toxicologic interactions, is demonstrated and evaluated by statistically…”
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Characterizing Risk for Cumulative Risk Assessments by MacDonell, Margaret M., Hertzberg, Richard C., Rice, Glenn E., Wright, J. Michael, Teuschler, Linda K.

“…In assessing environmental health risks, the risk characterization step synthesizes information gathered in evaluating exposures to stressors together with…”
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Impact of chemical proportions on the acute neurotoxicity of a mixture of seven carbamates in preweanling and adult rats by Moser, Virginia C, Padilla, Stephanie, Simmons, Jane Ellen, Haber, Lynne T, Hertzberg, Richard C

“…Statistical design and environmental relevance are important aspects of studies of chemical mixtures, such as pesticides. We used a dose-additivity model to…”
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Mechanistic modeling of salmonellosis: Update and future directions by Coleman, Margaret E., Marks, Harry M., Hertzberg, Richard C., Stephenson, Michele M.

“…Microbial risk assessors often make simplifying assumptions that lead to the selection of simple concave functions with low-dose linearity, consistent with…”
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Identification of developmentally toxic drinking water disinfection byproducts and evaluation of data relevant to mode of action by Colman, Joan, Rice, Glenn E., Wright, J. Michael, Hunter, E. Sidney, Teuschler, Linda K., Lipscomb, John C., Hertzberg, Richard C., Simmons, Jane Ellen, Fransen, Margaret, Osier, Mark, Narotsky, Michael G.

“…Reactions between chemicals used to disinfect drinking water and compounds present in source waters produce chemical mixtures containing hundreds of…”
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A four-step approach to evaluate mixtures for consistency with dose addition by Hertzberg, Richard C, Pan, Yi, Li, Ruosha, Haber, Lynne T, Lyles, Robert H, Herr, David W, Moser, Virginia C, Simmons, Jane Ellen

“…Abstract Mixture risk assessment is often hampered by the lack of dose–response information on the mixture being assessed, forcing reliance on component…”
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Assessing the mammalian toxicity of high-boiling point petroleum substances by Feder, Paul I., Hertzberg, Richard C.

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Incorporating nonchemical stressors into cumulative risk assessments by Rider, Cynthia V, Dourson, Michael L, Hertzberg, Richard C, Mumtaz, Moiz M, Price, Paul S, Simmons, Jane Ellen

“…The role of nonchemical stressors in modulating the human health risk associated with chemical exposures is an area of increasing attention. On 9 March 2011, a…”
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Corrigendum to A four-step approach to evaluate mixtures for consistency with dose addition [Toxicology 313 (November 2013) 134–144] by Hertzberg, Richard C, Pan, Yi, Li, Ruosha, Haber, Lynne T, Lyles, Robert H, Herr, David W, Moser, Virginia C, Simmons, Jane Ellen

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Evaluating Quantitative Formulas for Dose-Response Assessment of Chemical Mixtures by Hertzberg, Richard C., Teuschler, Linda K.

“…Risk assessment formulas are often distinguished from dose-response models by being rough but necessary. The evaluation of these rough formulas is described…”
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Synergy and other ineffective mixture risk definitions by Hertzberg, Richard C, MacDonell, Margaret M

“…A substantial effort has been spent over the past few decades to label toxicologic interaction outcomes as synergistic, antagonistic, or additive. Although…”
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Cholinesterase inhibition and depression of the photic after discharge of flash evoked potentials following acute or repeated exposures to a mixture of carbaryl and propoxur by Mwanza, Jean-Claude, Lyke, Danielle F., Hertzberg, Richard C., Haber, Lynne, Kohrman-Vincent, Melissa, Li, Ruosha, Pan, Yi, Lyles, Robert H., Simmons, Jane Ellen, MacMillan, Denise K., Zehr, R. Dan, Swank, Adam E., Herr, David W.

“…Previously, we reported that acute treatment with propoxur or carbaryl decreased the duration of the Photic After Discharge (PhAD) of Flash Evoked Potentials…”
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Cumulative Risk Assessment Toolbox: Methods and Approaches for the Practitioner by Haroun, Lynne A., MacDonell, Margaret M., Teuschler, Linda K., Rice, Glenn E., Hertzberg, Richard C., Butler, James P., Chang, Young-Soo, Clark, Shanna L., Johns, Alan P., Perry, Camarie S., Garcia, Shannon S., Jacobi, John H., Scofield, Marcienne A.

“…The historical approach to assessing health risks of environmental chemicals has been to evaluate them one at a time. In fact, we are exposed every day to a…”
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An approach for assessing human exposures to chemical mixtures in the environment by Rice, Glenn, MacDonell, Margaret, Hertzberg, Richard C., Teuschler, Linda, Picel, Kurt, Butler, Jim, Chang, Young-Soo, Hartmann, Heidi

“…Humans are exposed daily to multiple chemicals, including incidental exposures to complex chemical mixtures released into the environment and to combinations…”
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Component-Based and Whole-Mixture Techniques for Addressing the Toxicity Of Drinking-Water Disinfection By-Product Mixtures by Simmons, Jane Ellen, Teuschler, Linda K., Gennings, Chris, Speth, Thomas F., Richardson, Susan D., Miltner, Richard J., Narotsky, Michael G., Schenck, Kathleen D., Hunter, E. Sidney, Hertzberg, Richard C., Rice, Glenn

“…Chemical disinfection of water is of direct public health benefit as it results in decreased water-borne illness. The chemicals used to disinfect water react…”
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EPA project-level research strategies for chemical mixtures: targeted research for meaningful results by Teuschler, Linda K., Hertzberg, Richard C., Rice, Glenn E., Simmons, Jane Ellen

“…Project-level research strategies at the U.S. Environmental Protection Agency regarding chemical mixtures are impacted by administrative priorities, public…”
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Critical analysis of literature on low-dose synergy for use in screening chemical mixtures for risk assessment by Boobis, Alan, Budinsky, Robert, Collie, Shanna, Crofton, Kevin, Embry, Michelle, Felter, Susan, Hertzberg, Richard, Kopp, David, Mihlan, Gary, Mumtaz, Moiz, Price, Paul, Solomon, Keith, Teuschler, Linda, Yang, Raymond, Zaleski, Rosemary

“…There is increasing interest in the use of tiered approaches in risk assessment of mixtures or co-exposures to chemicals for prioritization. One possible…”
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