Search Results - "Hersperger, Adam R"

Perforin expression directly ex vivo by HIV-specific CD8 T-cells is a correlate of HIV elite control by Hersperger, Adam R, Pereyra, Florencia, Nason, Martha, Demers, Korey, Sheth, Prameet, Shin, Lucy Y, Kovacs, Colin M, Rodriguez, Benigno, Sieg, Scott F, Teixeira-Johnson, Leia, Gudonis, Debbie, Goepfert, Paul A, Lederman, Michael M, Frank, Ian, Makedonas, George, Kaul, Rupert, Walker, Bruce D, Betts, Michael R

“…Many immune correlates of CD8(+) T-cell-mediated control of HIV replication, including polyfunctionality, proliferative ability, and inhibitory receptor…”
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Perforin-dependent CD4⁺ T-cell cytotoxicity contributes to control a murine poxvirus infection by Fang, Min, Siciliano, Nicholas A, Hersperger, Adam R, Roscoe, Felicia, Hu, Angela, Ma, Xueying, Shamsedeen, Ahamed R, Eisenlohr, Laurence C, Sigal, Luis J

“…CD4 ⁺ T cells are generally regarded as helpers and regulators of the immune response. Although cytolytic CD4 ⁺ T cells have been described, whether those…”
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Ectromelia-encoded virulence factor C15 specifically inhibits antigen presentation to CD4+ T cells post peptide loading by Forsyth, Katherine S, Roy, Nathan H, Peauroi, Elise, DeHaven, Brian C, Wold, Erik D, Hersperger, Adam R, Burkhardt, Janis K, Eisenlohr, Laurence C

“…Smallpox and monkeypox pose severe threats to human health. Other orthopoxviruses are comparably virulent in their natural hosts, including ectromelia, the…”
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Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells by Makedonas, George, Hutnick, Natalie, Haney, Danielle, Amick, Alexandra C, Gardner, Jay, Cosma, Gabriela, Hersperger, Adam R, Dolfi, Douglas, Wherry, E John, Ferrari, Guido, Betts, Michael R

“…The prevailing paradigm of T lymphocyte control of viral replication is that the protective capacity of virus-specific CD8(+) T cells is directly proportional…”
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Comparable Polyfunctionality of Ectromelia Virus- and Vaccinia Virus-Specific Murine T Cells despite Markedly Different In Vivo Replication and Pathogenicity by HERSPERGER, Adam R, SICILIANO, Nicholas A, EISENLOHR, Laurence C

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Ectopic expression of vaccinia virus E3 and K3 cannot rescue ectromelia virus replication in rabbit RK13 cells by Hand, Erin S, Haller, Sherry L, Peng, Chen, Rothenburg, Stefan, Hersperger, Adam R

“…As a group, poxviruses have been shown to infect a wide variety of animal species. However, there is individual variability in the range of species able to be…”
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The epidermal growth factor ortholog of ectromelia virus activates EGFR/ErbB1 and demonstrates mitogenic function in vitro by Morgis, Rebecca A., Haan, Kaylyn, Schrey, Julie M., Zimmerman, Rosie M., Hersperger, Adam R.

“…Many poxviruses produce proteins that are related to epidermal growth factor (EGF). Prior genome sequencing of ectromelia virus revealed a gene predicted to…”
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Human GUCY2C-Targeted Chimeric Antigen Receptor (CAR)-Expressing T Cells Eliminate Colorectal Cancer Metastases by Magee, Michael S, Abraham, Tara S, Baybutt, Trevor R, Flickinger, Jr, John C, Ridge, Natalie A, Marszalowicz, Glen P, Prajapati, Priyanka, Hersperger, Adam R, Waldman, Scott A, Snook, Adam E

“…One major hurdle to the success of adoptive T-cell therapy is the identification of antigens that permit effective targeting of tumors in the absence of…”
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Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression by Hersperger, Adam R., Martin, Jeffrey N., Shin, Lucy Y., Sheth, Prameet M., Kovacs, Colin M., Cosma, Gabriela L., Makedonas, George, Pereyra, Florencia, Walker, Bruce D., Kaul, Rupert, Deeks, Steven G., Betts, Michael R.

“…Recent data suggest that CD8+ T-cell effector activity is an important component in the control of HIV replication in elite controllers (ECs). One critical…”
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Qualitative features of the HIV-specific CD8+ T-cell response associated with immunologic control by Hersperger, Adam R, Migueles, Stephen A, Betts, Michael R, Connors, Mark

“…PURPOSE OF REVIEWOver the past 2 years, a clearer picture has emerged regarding the properties of HIV-specific CD8 T cells associated with immunologic control…”
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Ectromelia virus accumulates less double-stranded RNA compared to vaccinia virus in BS-C-1 cells by Frey, Tiffany R, Lehmann, Michael H, Ryan, Colton M, Pizzorno, Marie C, Sutter, Gerd, Hersperger, Adam R

“…Abstract Most orthopoxviruses, including vaccinia virus (VACV), contain genes in the E3L and K3L families. The protein products of these genes have been shown…”
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Flow cytometric detection of perforin upregulation in human CD8 T cells by Hersperger, Adam R, Makedonas, George, Betts, Michael R

“…Perforin and granzymes work synergistically to induce apoptosis in target cells recognized by cytotoxic T lymphocytes. While perforin is readily detectable by…”
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Ectromelia virus lacking the E3L ortholog is replication-defective and nonpathogenic but does induce protective immunity in a mouse strain susceptible to lethal mousepox by Frey, Tiffany R., Forsyth, Katherine S., Sheehan, Maura M., De Haven, Brian C., Pevarnik, Julia G., Hand, Erin S., Pizzorno, Marie C., Eisenlohr, Laurence C., Hersperger, Adam R.

“…All known orthopoxviruses, including ectromelia virus (ECTV), contain a gene in the E3L family. The protein product of this gene, E3, is a double-stranded…”
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Impact of distinct poxvirus infections on the specificities and functionalities of CD4+ T cell responses by Siciliano, Nicholas A, Hersperger, Adam R, Lacuanan, Aimee M, Xu, Ren-Huan, Sidney, John, Sette, Alessandro, Sigal, Luis J, Eisenlohr, Laurence C

“…The factors that determine CD4+ T cell (TCD4+) specificities, functional capacity, and memory persistence in response to complex pathogens remain unclear. We…”
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Epithelial immunization induces polyfunctional CD8+ T cells and optimal mousepox protection by Hersperger, Adam R, Siciliano, Nicholas A, DeHaven, Brian C, Snook, Adam E, Eisenlohr, Laurence C

“…We assessed several routes of immunization with vaccinia virus (VACV) in protecting mice against ectromelia virus (ECTV). By a wide margin, skin scarification…”
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Rapid Up-Regulation and Granule-Independent Transport of Perforin to the Immunological Synapse Define a Novel Mechanism of Antigen-Specific CD8+ T Cell Cytotoxic Activity by Makedonas, George, Banerjee, Pinaki P, Pandey, Rahul, Hersperger, Adam R, Sanborn, Keri B, Hardy, Gareth A. D, Orange, Jordan S, Betts, Michael R

“…CTL are endowed with the ability to eliminate pathogens through perforin-mediated cytotoxic activity. The mechanism for perforin-mediated Ag-specific killing…”
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Ectromelia-encoded virulence factor C15 specifically inhibits antigen presentation to CD4.sup.+ T cells post peptide loading by Forsyth, Katherine S, Roy, Nathan H, Peauroi, Elise, DeHaven, Brian C, Wold, Erik D, Hersperger, Adam R, Burkhardt, Janis K, Eisenlohr, Laurence C

“…Smallpox and monkeypox pose severe threats to human health. Other orthopoxviruses are comparably virulent in their natural hosts, including ectromelia, the…”
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GUCY2C-targeted chimeric antigen receptor-expressing T cells mediate anti-tumor therapy in a mouse model of metastatic colorectal cancer by Magee, Michael S, Snook, Adam E, Hersperger, Adam R, Marszalowicz, Glen, Waldman, Scott A

“…GUCY2C is a membrane-bound cyclase selectively expressed on the apical surfaces of intestinal epithelial cells facing the intestinal lumen, sequestered from…”
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Ectopic Expression of Vaccinia Virus E3 and K3 Cannot Rescue Ectromelia Virus Replication in Rabbit RK13 Cells: e0119189 by Hand, Erin S, Haller, Sherry L, Peng, Chen, Rothenburg, Stefan, Hersperger, Adam R

“…As a group, poxviruses have been shown to infect a wide variety of animal species. However, there is individual variability in the range of species able to be…”
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GUCY2C-targeted chimeric antigen receptor expressing T cells extend survival in a therapeutic mouse model of metastatic colorectal cancer by Magee, Michael S, Snook, Adam E, Hersperger, Adam R, Marszalowicz, Glen P, Waldman, Scott A

“…Adoptive T cell therapy (ACT) is an emerging cancer treatment paradigm with success in early phase clinical trials in melanoma and B cell leukemia. However,…”
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