Search Results - "Herson, P.S"

Therapeutic hypothermia protects against ischemia-induced impairment of synaptic plasticity following juvenile cardiac arrest in sex-dependent manner by Dietz, R.M, Deng, G, Orfila, J.E, Hui, X, Traystman, R.J, Herson, P.S

“…Highlights • Synaptic plasticity in juvenile mice is impaired 7 days after cardiac arrest. • Therapeutic hypothermia protects synaptic function when applied…”
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Region-specific role for GluN2B-containing NMDA receptors in injury to Purkinje cells and CA1 neurons following global cerebral ischemia by Quillinan, N, Grewal, H, Deng, G, Shimizu, K, Yonchek, J.C, Strnad, F, Traystman, R.J, Herson, P.S

“…Highlights • Immunohistochemistry and cell density analysis of ischemic injury in cerebellum. • Purkinje cell death rapid and not via apoptosis following…”
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TRPM2 channel activation following in vitro ischemia contributes to male hippocampal cell death by Verma, S., Quillinan, N., Yang, Y.-F., Nakayama, S., Cheng, J., Kelley, M.H., Herson, P.S.

“…► TRPM2 inhibition decrease OGD-induced hippocampal cell death in male preferentially. ► No sex difference in TRPM2 contribution to H2O2-induced hippocampal…”
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Isoflurane preconditioning neuroprotection in experimental focal stroke is androgen-dependent in male mice by Zhu, W, Wang, L, Zhang, L, Palmateer, J.M, Libal, N.L, Hurn, P.D, Herson, P.S, Murphy, S.J

“…Abstract Isoflurane preconditioning neuroprotection in experimental stroke is male-specific. The role of androgens in the ischemic sensitivity of isoflurane…”
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Poly (ADP-ribose) polymerase-1 initiated neuronal cell death pathway—do androgens matter? by Vagnerova, K, Liu, K, Ardeshiri, A, Cheng, J, Murphy, S.J, Hurn, P.D, Herson, P.S

“…Abstract Activation of poly (ADP-ribose) polymerases (PARP) contributes to ischemic damage by causing neuronal nicotinamide adenine dinucleotide (NAD+ )…”
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Characterization and Optimization of the Novel Transient Receptor Potential Melastatin 2 Antagonist tatM2NX by Cruz-Torres, I, Backos, D S, Herson, P S

“…Transient receptor potential melastatin 2 (TRPM2) is a calcium-permeable channel activated by adenosine diphosphate ribose metabolites and oxidative stress…”
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Single dose of 17β-estradiol provides transient neuroprotection in female juvenile mice after cardiac-arrest and cardiopulmonary resuscitation by Quillinan, N., Dingman, A.L., Deng, G., Tatum, S., Orfila, J.E., Clevenger, A.C., Klawitter, J., Traystman, R.J., Herson, P.S.

“…Each year there are approximately 7000 out of hospital cardiac arrests in the pediatric population, with 30% resuscitation rate and a 6–10% rate of survival to…”
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A novel mouse model of pediatric cardiac arrest and cardiopulmonary resuscitation reveals age-dependent neuronal sensitivities to ischemic injury by Deng, G., Yonchek, J.C., Quillinan, N., Strnad, F.A., Exo, J., Herson, P.S., Traystman, R.J.

“…•New mouse model of pediatric cardiac arrest & CPR to study global cerebral ischemia.•Pediatric brain less sensitive to global ischemia than adult…”
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PARP-1 initiated neuronal cell death pathway–do androgens matter? by Vagnerova, K., Liu, K., Ardeshiri, A., Cheng, J., Murphy, S.J., Hurn, P.D., Herson, P.S.

“…Activation of poly (ADP-ribose) polymerases contributes to ischemic damage by causing neuronal NAD + depletion, release of apoptosis-inducing factor and…”
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