Search Results - "Hershkoviz, R"

Human mast cells release metalloproteinase-9 on contact with activated T cells: juxtacrine regulation by TNF-alpha by Baram, D, Vaday, G G, Salamon, P, Drucker, I, Hershkoviz, R, Mekori, Y A

“…Mast cells, essential effector cells in allergic inflammation, have been found to be activated in T cell-mediated inflammatory processes in accordance with…”
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Combinatorial signals by inflammatory cytokines and chemokines mediate leukocyte interactions with extracellular matrix by Vaday, Gayle G., Franitza, Susanne, Schor, Hagai, Hecht, Iris, Brill, Alexander, Cahalon, Liora, Hershkoviz, Rami, Lider, Ofer

“…On their extravasation from the vascular system into inflamed tissues, leukocytes must maneuver through a complex insoluble network of molecules termed the…”
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Specific inhibition of T‐cell adhesion to extracellular matrix and proinflammatory cytokine secretion by human recombinant galectin‐1 by Rabinovich, G A, Ariel, A, Hershkoviz, R, Hirabayashi, J, Kasai, K I, Lider, O

“…The migration of immune cells through the extracellular matrix (ECM) towards inflammatory sites is co‐ordinated by receptors recognizing ECM glycoproteins,…”
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Induction of mast cell interactions with blood vessel wall components by direct contact with intact T cells or T cell membranes in vitro by Brill, A., Baram, D., Sela, U., Salamon, P., Mekori, Y. A., Hershkoviz, R.

“…Summary Background Mast cells exert profound pleiotropic effects on immune cell reactions at inflammatory sites, where they are most likely influenced not only…”
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TNF-alpha associated with extracellular matrix fibronectin provides a stop signal for chemotactically migrating T cells by Franitza, S, Hershkoviz, R, Kam, N, Lichtenstein, N, Vaday, G G, Alon, R, Lider, O

“…The migration of T cells into extravascular sites of inflammation is regulated by information derived from the molecular structure of the invaded tissue and…”
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Fibronectin-bound TNF-α stimulates monocyte matrix metalloproteinase-9 expression and regulates chemotaxis by Vaday, Gayle G., Hershkoviz, Rami, Rahat, Michal A., Lahat, Nitza, Cahalon, Liora, Lider, Ofer

“…Tumor necrosis factor α (TNF‐α) is a proinflammatory cytokine implicated in the stimulation of matrix metalloproteinase (MMP) production by several cell types…”
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Induction of interactions between CD44 and hyaluronic acid by a short exposure of human T cells to diverse pro‐inflammatory mediators by Ariel, A., Lider, O., Brill, A., Cahalon, L., Savion, N., Varon, D., Hershkoviz, R.

“…Summary Migration of T cells into extravascular sites of inflammation is mediated by cell–cell and cell–matrix adhesion receptors, including the…”
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Heparin and low‐molecular‐weight heparin (enoxaparin) significantly ameliorate experimental colitis in rats by Dotan, I., Hershkoviz, R., Karmeli, F., Brazowski, E., Peled, Y., Rachmilewitz, D., Halpern, Z.

“…Background and aims: The anticoagulants, unfractionated heparin and low‐molecular‐weight heparin, demonstrated anti‐inflammatory effects in animal models and…”
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Effect of Linomide on adhesion molecules, TNF-α, nitrogen oxide, and cell adhesion by Abdul-Hai, A., Hershkoviz, R., Weiss, L., Lider, O., Slavin, S.

“…Linomide (quinoline-3-carboxamide) is an immunomodulator with anti-inflammatory effects in rodents with autoimmune diseases. Its mode of action still remains…”
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Augmentation of RANTES-Induced Extracellular Signal-Regulated Kinase Mediated Signaling and T Cell Adhesion by Elastase-Treated Fibronectin by Brill, Alexander, Hershkoviz, Rami, Vaday, Gayle G, Chowers, Yehuda, Lider, Ofer

“…T cells migrating across extracellular matrix (ECM) barriers toward their target, the inflammatory site, should respond to chemoattractant cytokines and to the…”
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Inhibitory effects of low molecular weight heparin on mediator release by mast cells: preferential inhibition of cytokine production and mast cell‐dependent cutaneous inflammation by BARAM, D., RASHKOVSKY, M., HERSHKOVIZ, R., DRUCKER, I., RESHEF, T., BEN‐SHITRIT, S., MEKORI, Y. A.

“…There has been substantial evidence that suggests that heparin may modulate various aspects of immune function and inflammation in addition to its well known…”
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Cell Surface-Expressed Moesin-Like Receptor Regulates T Cell Interactions with Tissue Components and Binds an Adhesion-Modulating IL-2 Peptide Generated by Elastase by Ariel, Amiram, Hershkoviz, Rami, Altbaum-Weiss, Idit, Ganor, Sharon, Lider, Ofer

“…The adhesion of leukocytes to the extracellular matrix (ECM) depends on their responses to variations in the chemotactic signals in their milieu, as well as on…”
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Extracellular matrix-anchored serum amyloid A preferentially induces mast cell adhesion by Hershkoviz, R, Preciado-Patt, L, Lider, O, Fridkin, M, Dastych, J, Metcalfe, D D, Mekori, Y A

“…Mast cells are known to accumulate in various inflammatory processes, some of which are known to be associated with increased local and systemic levels of…”
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Tumour necrosis factor-alpha interacts with laminin and functions as a pro-adhesive cytokine by Hershkoviz, R, Goldkorn, I, Lider, O

“…Certain cytokines, chemokines and growth factors interact with components of the extracellular matrix (ECM) and, in particular, sulphated polysaccharides and…”
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Disaccharides generated from heparan sulphate or heparin modulate chemokine‐induced T‐cell adhesion to extracellular matrix by Hershkoviz, R., Schor, H., Ariel, A., Hecht, I., Cohen, I. R., Lider, O., Cahalon, L.

“…Summary We have found previously that disaccharides (DS) enzymatically generated from heparin or heparan sulphate can modulate tumour necrosis factor‐α (TNF‐α)…”
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Analysis of Arg-Gly-Asp mimetics and soluble receptor of tumour necrosis factor as therapeutic modalities for concanavalin A induced hepatitis in mice by Bruck, R, Shirin, H, Hershkoviz, R, Lider, O, Kenet, G, Aeed, H, Matas, Z, Zaidel, L, Halpern, Z

“…BACKGROUND/AIMS: It has been shown that synthetic non-peptidic analogues of Arg-Gly-Asp, a major cell adhesive ligand of extracellular matrix, prevented an…”
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A Disaccharide that Inhibits Tumor Necrosis Factor α is Formed from the Extracellular Matrix by the Enzyme Heparanase by Lider, Ofer, Cahalon, Liora, Gilat, Dalia, Hershkoviz, Rami, Siegel, Daniel, Margalit, Raanan, Shoseyov, Oded, Cohen, Irun R.

“…The activation of T cells by antigens or mitogens leads to the secretion of cytokines and enzymes that shape the inflammatory response. Among these molecular…”
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CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+stem/progenitor cells to bone marrow by Avigdor, Abraham, Goichberg, Polina, Shivtiel, Shoham, Dar, Ayelet, Peled, Amnon, Samira, Sarit, Kollet, Orit, Hershkoviz, Rami, Alon, Ronen, Hardan, Izhar, Ben-Hur, Herzl, Naor, David, Nagler, Arnon, Lapidot, Tsvee

“…Trafficking of human CD34+stem/progenitor cells (HSCs/HPCs) is regulated by chemokines, cytokines, proteolytic enzymes, and adhesion molecules. We report that…”
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Non-peptidic analogs of the cell adhesion motif RGD prevent experimental liver injury by Bruck, R, Hershkoviz, R, Lider, O, Shirin, H, Aeed, H, Halpern, Z

“…In chronic viral hepatitis, autoimmune hepatitis, and some chronic cholestatic liver diseases, T lymphocytes serve as effector cells of the immunostimulatory…”
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Amelioration of experimental colitis by thalidomide by Kenet, G, Wardi, J, Avni, Y, Aeed, H, Shirin, H, Zaidel, L, Hershkoviz, R, Bruck, R

“…Rectal administration of iodoacetamide induces colitis by blocking sulphhydryl groups and generating inflammatory mediators. Thalidomide, a non-barbiturate…”
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