Congenital absence of salivary glands in Down syndrome

Background Children with Down syndrome have different saliva composition compared to normal children. The presence or absence of the salivary glands has not been previously reported. Objective To examine the presence or absence of the salivary glands in children with Down syndrome. Methods 15 childr...

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Bibliographic Details
Published in:	Archives of disease in childhood Vol. 98; no. 10; pp. 781 - 783
Main Authors:	Odeh, Marwan, Hershkovits, Miriyam, Bornstein, Jacob, Loberant, Norman, Blumenthal, Monique, Ophir, Ella
Format:	Journal Article
Language:	English
Published:	London BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health 01-10-2013 BMJ Publishing Group BMJ Publishing Group Ltd BMJ Publishing Group LTD
Subjects:	Adolescent Biological and medical sciences Child Child, Preschool Chromosome aberrations Congenital Abnorm Consent Control Groups Demographic aspects Down syndrome Down Syndrome - complications Down Syndrome - diagnostic imaging Female General aspects Humans Imaging Infant Male Medical genetics Medical sciences Miscellaneous Parents Pregnancy Prevention and actions Public health. Hygiene Public health. Hygiene-occupational medicine Salivary glands Salivary Glands - abnormalities Salivary Glands - diagnostic imaging Statistical Analysis Ultrasonic imaging Ultrasonography Israel Chromosomal aberration Human Pediatrics Trisomy Congenital Digestive system Chromosome G21 Aneuploidy Salivary gland Down syndrome Congenital disease Child Public health Congenital Abnorm Imaging
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Summary:	Background Children with Down syndrome have different saliva composition compared to normal children. The presence or absence of the salivary glands has not been previously reported. Objective To examine the presence or absence of the salivary glands in children with Down syndrome. Methods 15 children with Down syndrome underwent an ultrasound examination of the salivary glands. The control group consisted of 31 healthy children. The areas of the parotid and submandibular glands on both sides were scanned in an attempt to demonstrate all four glands. The result was reported as ‘present’ or ‘absent’. Results In four children out of 15 with Down syndrome, one or more salivary glands were absent (26.7%), while in the controls all salivary glands were present. The difference between the groups was statistically significant (p=0.008). There was no significant difference between the groups regarding age and sex. Conclusions At least one salivary gland is undetected by ultrasound in some children with Down syndrome.
Bibliography:	ArticleID:archdischild-2013-303841 local:archdischild;98/10/781 href:archdischild-98-781.pdf PMID:23908188 ark:/67375/NVC-8XPM23CK-L istex:FDD185EA689633ED5534CC503B3786060F6F366B ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0003-9888 1468-2044
DOI:	10.1136/archdischild-2013-303841