Search Results - "Hershfinkel, Michal"

The Zinc Sensing Receptor, ZnR/GPR39, in Health and Disease by Hershfinkel, Michal

“…A distinct G-protein coupled receptor that senses changes in extracellular Zn , ZnR/GPR39, was found in cells from tissues in which Zn plays a physiological…”
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The zinc sensing receptor, ZnR/GPR39, in health and disease by Sunuwar, Laxmi, Gilad, David, Hershfinkel, Michal

“…While zinc has had a well-established structural role for many years, it is only during the last two decades that its role as a signaling molecule has been…”
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Elucidating the H+ Coupled Zn2+ Transport Mechanism of ZIP4; Implications in Acrodermatitis Enteropathica by Hoch, Eitan, Levy, Moshe, Hershfinkel, Michal, Sekler, Israel

“…Cellular Zn2+ homeostasis is tightly regulated and primarily mediated by designated Zn2+ transport proteins, namely zinc transporters (ZnTs; SLC30) that…”
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The neurophysiology and pathology of brain zinc by Sensi, Stefano L, Paoletti, Pierre, Koh, Jae-Young, Aizenman, Elias, Bush, Ashley I, Hershfinkel, Michal

“…Our understanding of the roles played by zinc in the physiological and pathological functioning of the brain is rapidly expanding. The increased availability…”
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NCLX is an essential component of mitochondrial Na⁺/Ca²⁺ exchange by Palty, Raz, Silverman, William F, Hershfinkel, Michal, Caporale, Teresa, Sensi, Stefano L, Parnis, Julia, Nolte, Christiane, Fishman, Daniel, Shoshan-Barmatz, Varda, Herrmann, Sharon, Khananshvili, Daniel, Sekler, Israel

“…Mitochondrial Ca²⁺ efflux is linked to numerous cellular activities and pathophysiological processes. Although it is established that an Na⁺-dependent…”
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Homeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures by Gilad, David, Shorer, Sharon, Ketzef, Maya, Friedman, Alon, Sekler, Israel, Aizenman, Elias, Hershfinkel, Michal

“…Abstract The aim of this study was to investigate the role of the synaptic metabotropic zinc receptor mZnR/GPR39 in physiological adaptation to epileptic…”
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Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn2+ over Cd2+ selectivity by Hoch, Eitan, Lin, Wei, Chai, Jin, Hershfinkel, Michal, Fu, Dax, Sekler, Israel

“…Zinc and cadmium are similar metal ions, but though Zn2+ is an essential nutrient, Cd2+ is a toxic and common pollutant linked to multiple disorders. Faster…”
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Mobile zinc increases rapidly in the retina after optic nerve injury and regulates ganglion cell survival and optic nerve regeneration by Li, Yiqing, Andereggen, Lukas, Yuki, Kenya, Omura, Kumiko, Yin, Yuqin, Gilbert, Hui-Ya, Erdogan, Burcu, Asdourian, Maria S., Shrock, Christine, de Lima, Silmara, Apfel, Ulf-Peter, Zhuo, Yehong, Hershfinkel, Michal, Lippard, Stephen J., Rosenberg, Paul A., Benowitz, Larry

“…Retinal ganglion cells (RGCs), the projection neurons of the eye, cannot regenerate their axons once the optic nerve has been injured and soon begin to die…”
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PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons by Kostic, Marko, Ludtmann, Marthe H.R., Bading, Hilmar, Hershfinkel, Michal, Steer, Erin, Chu, Charleen T., Abramov, Andrey Y., Sekler, Israel

“…Mitochondrial Ca2+ overload is a critical, preceding event in neuronal damage encountered during neurodegenerative and ischemic insults. We found that loss of…”
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Molecular Identity and Functional Properties of the Mitochondrial Na+/Ca2+ Exchanger by Palty, Raz, Hershfinkel, Michal, Sekler, Israel

“…The mitochondrial membrane potential that powers the generation of ATP also facilitates mitochondrial Ca2+ shuttling. This process is fundamental to a wide…”
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Mitochondria control store‐operated Ca2+ entry through Na+ and redox signals by Ben‐Kasus Nissim, Tsipi, Zhang, Xuexin, Elazar, Assaf, Roy, Soumitra, Stolwijk, Judith A, Zhou, Yandong, Motiani, Rajender K, Gueguinou, Maxime, Hempel, Nadine, Hershfinkel, Michal, Gill, Donald L, Trebak, Mohamed, Sekler, Israel

“…Mitochondria exert important control over plasma membrane (PM) Orai1 channels mediating store‐operated Ca 2+ entry (SOCE). Although the sensing of endoplasmic…”
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Zinc Signaling in the Mammary Gland: For Better and for Worse by Chakraborty, Moumita, Hershfinkel, Michal

“…Zinc (Zn2+) plays an essential role in epithelial physiology. Among its many effects, most prominent is its action to accelerate cell proliferation, thereby…”
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Zinc Released from Injured Cells Is Acting via the Zn2+-sensing Receptor, ZnR, to Trigger Signaling Leading to Epithelial Repair by Sharir, Haleli, Zinger, Anna, Nevo, Andrey, Sekler, Israel, Hershfinkel, Michal

“…A role for Zn2+ in accelerating wound healing is established, yet, the signaling pathways linking Zn2+ to tissue repair are not well known. We show that in the…”
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ZnR/GPR39 upregulation of K+/Cl−-cotransporter 3 in tamoxifen resistant breast cancer cells by Mero, Maayan, Asraf, Hila, Sekler, Israel, Taylor, Kathryn M., Hershfinkel, Michal

“…[Display omitted] •ZnR/GPR39 activates KCC3 in tamoxifen resistant breast cancer cells.•Zn2+ does not activate Ca2+ signaling or KCC3 in estrogen-dependent…”
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Identification of the Zn2+ Binding Site and Mode of Operation of a Mammalian Zn2+ Transporter by Ohana, Ehud, Hoch, Eitan, Keasar, Chen, Kambe, Taiho, Yifrach, Ofer, Hershfinkel, Michal, Sekler, Israel

“…Vesicular zinc transporters (ZnTs) play a critical role in regulating Zn2+ homeostasis in various cellular compartments and are linked to major diseases…”
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Upregulation of KCC2 activity by zinc-mediated neurotransmission via the mZnR/GPR39 receptor by Chorin, Ehud, Vinograd, Ofir, Fleidervish, Ilya, Gilad, David, Herrmann, Sharon, Sekler, Israel, Aizenman, Elias, Hershfinkel, Michal

“…Vesicular Zn(2+) regulates postsynaptic neuronal excitability upon its corelease with glutamate. We previously demonstrated that synaptic Zn(2+) acts via a…”
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Synaptically Released Zinc Triggers Metabotropic Signaling via a Zinc-Sensing Receptor in the Hippocampus by Besser, Limor, Chorin, Ehud, Sekler, Israel, Silverman, William F, Atkin, Stan, Russell, James T, Hershfinkel, Michal

“…Zn(2+) is coreleased with glutamate from mossy fiber terminals and can influence synaptic function. Here, we demonstrate that synaptically released Zn(2+)…”
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Mitotic slippage and expression of survivin are linked to differential sensitivity of human cancer cell-lines to the Kinesin-5 inhibitor monastrol by Asraf, Hila, Avunie-Masala, Rachel, Hershfinkel, Michal, Gheber, Larisa

“…The mitotic Kinesin-5 motor proteins crosslink and slide apart antiparallel spindle microtubules, thus performing essential functions in mitotic spindle…”
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Optogenetic control of mitochondrial metabolism and Ca2+ signaling by mitochondria-targeted opsins by Tkatch, Tatiana, Greotti, Elisa, Baranauskas, Gytis, Pendin, Diana, Roy, Soumitra, Nita, Luliaoana I., Wettmarshausen, Jennifer, Prigge, Matthias, Yizhar, Ofer, Shirihai, Orian S., Fishman, Daniel, Hershfinkel, Michal, Fleidervish, Ilya A., Perocchi, Fabiana, Pozzan, Tullio, Sekler, Israel

“…Key mitochondrial functions such as ATP production, Ca2+ uptake and release, and substrate accumulation depend on the proton electrochemical gradient (ΔμH⁺)…”
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Mechanism and regulation of cellular zinc transport by Sekler, Israel, Sensi, Stefano L, Hershfinkel, Michal, Silverman, William F

“…Zinc is an essential cofactor for the activity and folding of up to ten percent of mammalian proteins and can modulate the function of many others. Because of…”
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