Search Results - "Hershberg, R M"

A phase 2, randomized, double-blind, placebo- controlled study of chemo-immunotherapy combination using motolimod with pegylated liposomal doxorubicin in recurrent or persistent ovarian cancer: a Gynecologic Oncology Group partners study by Monk, B.J., Brady, M.F., Aghajanian, C., Lankes, H.A., Rizack, T., Leach, J., Fowler, J.M., Higgins, R., Hanjani, P., Morgan, M., Edwards, R., Bradley, W., Kolevska, T., Foukas, P., Swisher, E.M., Anderson, K.S., Gottardo, R., Bryan, J.K., Newkirk, M., Manjarrez, K.L., Mannel, R.S., Hershberg, R.M., Coukos, G.

“…A phase 2, randomized, placebo-controlled trial was conducted in women with recurrent epithelial ovarian carcinoma to evaluate the efficacy and safety of…”
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Highly polarized HLA class II antigen processing and presentation by human intestinal epithelial cells by Hershberg, R M, Cho, D H, Youakim, A, Bradley, M B, Lee, J S, Framson, P E, Nepom, G T

“…The high concentration of foreign antigen in the lumen of the gastrointestinal tract is separated from the underlying lymphocytes by a single cell layer of…”
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Intestinal epithelial cells use two distinct pathways for HLA class II antigen processing by Hershberg, R M, Framson, P E, Cho, D H, Lee, L Y, Kovats, S, Beitz, J, Blum, J S, Nepom, G T

“…Intestinal epithelial cells express a low level of HLA class II molecules constitutively, with elevated levels seen in the setting of mucosal inflammation…”
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Polarized expression and function of the costimulatory molecule CD58 on human intestinal epithelial cells by Framson, Paul E., Cho, Diane H., Lee, Lawrence Y., Hershberg ,‡, Robert M.

“…Background & Aims: Intestinal epithelial cells (IECs) can process foreign protein antigens and display antigenic peptides to CD4 + T lymphocytes via HLA class…”
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Hypoxia-inducible factor 1-dependent induction of intestinal trefoil factor protects barrier function during hypoxia by Furuta, G T, Turner, J R, Taylor, C T, Hershberg, R M, Comerford, K, Narravula, S, Podolsky, D K, Colgan, S P

“…Mucosal organs such as the intestine are supported by a rich and complex underlying vasculature. For this reason, the intestine, and particularly…”
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Bacterial flagellin is a dominant antigen in Crohn disease by Lodes, Michael J, Cong, Yingzi, Elson, Charles O, Mohamath, Raodoh, Landers, Carol J, Targan, Stephan R, Fort, Madeline, Hershberg, Robert M

“…Chronic intestinal inflammation, as seen in inflammatory bowel disease (IBD), results from an aberrant and poorly understood mucosal immune response to the…”
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Antibodies to CBir1 Flagellin Define a Unique Response That Is Associated Independently With Complicated Crohn’s Disease by Targan, Stephan R., Landers, Carol J., Yang, Huiying, Lodes, Michael J., Cong, Yingzi, Papadakis, Konstantinos A., Vasiliauskas, Eric, Elson, Charles O., Hershberg, Robert M.

“…Background & Aims: Antibody responses to certain microbial antigens define heterogeneous groups of Crohn’s patients; multiple and high-level responses to these…”
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What's so (co)stimulating about the intestinal epithelium? by Hershberg, Robert M., Blumberg, Richard S.

“…GASTROENTEROLOGY 1999;117:726-728…”
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Structure-Activity Relationship of Synthetic Toll-like Receptor 4 Agonists by Stöver, Axel G., Da Silva Correia, Jean, Evans, Jay T., Cluff, Christopher W., Elliott, Mark W., Jeffery, Eric W., Johnson, David A., Lacy, Michael J., Baldridge, Jory R., Probst, Peter, Ulevitch, Richard J., Persing, David H., Hershberg, Robert M.

“…Important questions remain regarding the impact of variations in the structure of the lipid A portion of lipopolysaccharide on activation of cells via the…”
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Serum Immune Responses Predict Rapid Disease Progression among Children with Crohn's Disease: Immune Responses Predict Disease Progression by DUBINSKY, Maria C, LIN, Ying-Chao, ISRAEL, David, BAHAR, Ron, CHRISTIE, Dennis, WAHBEH, Ghassan, SILBER, Gary, DALLAZADEH, Saied, SHAH, Praful, THOMAS, Danny, KELTS, Drew, HERSHBERG, Robert M, DUTRIDGE, Debra, ELSON, Charles O, TARGAN, Stephan R, TAYLOR, Kent D, ROTTER, Jerome I, HUIYING YANG, PICORNELL, Yoana, LANDERS, Carol J, FARRIOR, Sharmayne, WROBEL, Iwona, QUIROS, Antonio, VASILIAUSKAS, Eric A, GRILL, Bruce

“…Crohn's disease (CD) is a heterogeneous disorder characterized by diverse clinical phenotypes. Childhood-onset CD has been described as a more aggressive…”
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Ligation of Intestinal Epithelial CD1d Induces Bioactive IL-10: Critical Role of the Cytoplasmic Tail in Autocrine Signaling by Colgan, Sean P., Hershberg, Robert M., Furuta, Glenn T., Blumberg, Richard S.

“…The intestinal epithelium is anatomically positioned to serve as the critical interface between the lumen and the mucosal immune system. In addition to MHC…”
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Critical role of cAMP response element binding protein expression in hypoxia-elicited induction of epithelial tumor necrosis factor-alpha by Taylor, C T, Fueki, N, Agah, A, Hershberg, R M, Colgan, S P

“…Tissue hypoxia is intimately associated with a number of chronic inflammatory conditions of the intestine. In this study, we investigated the impact of hypoxia…”
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Retroviral Vector-Mediated Gene Transfer into Human Hematopoietic Progenitor Cells by Gruber, Harry E., Finley, Kim D., Hershberg, Robert M., Katzman, Scott S., Laikind, Paul K., Seegmiller, J. Edwin, Friedmann, Theodore, Yee, Jiing-Kuan, Jolly, Douglas J.

“…The transfer of the human gene for hypoxanthine phosphoribosyltransferase (HPRT) into human bone marrow cells was accomplished by use of a retroviral vector…”
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immunotherapy of cancer Active8: A randomized, double-blind, placebo-controlled study of chemotherapy plus cetuximab in combination with motolimod immunotherapy in patients with recurrent or metastatic squamous cell carcinoma of the head and neck by Cohen, E., Saba, N.F., Gitlitz, B., Haddad, R., Sukari, A., Neupane, P., Morris, J.C., Misiukiewicz, K., Manjarrez, K.L., Dietsch, G.N., Bryan, J.K., Hershberg, R.M., Ferris, R.L.

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Human CD1d associates with prolyl-4-hydroxylase during its biosynthesis by Kim, Hyun Sil, Colgan, Sean P., Pitman, Richard, Hershberg, Robert M., Blumberg, Richard S.

“…Recent studies have shown that the CD1 family of proteins present various glycolipid antigens to subsets of T cells. CD1d is expressed on human intestinal…”
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Antigen processing and presentation by intestinal epithelial cells – polarity and complexity by Hershberg, Robert M, Mayer, Lloyd F

“…The mechanisms by which gut-associated lymphoid tissue (GALT) maintains a balance between oral tolerance and active immune response in the face of exposure to…”
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Phase I clinical trial of VTX-2337, a selective toll-like receptor 8 (TLR8) agonist, in patients with advanced solid tumors by Cohen, P. A., Northfelt, D. W., Weiss, G. J., Von Hoff, D. D., Manjarrez, K., Dietsch, G., Hershberg, R. M., Ramanathan, R. K.

“…Abstract only…”
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Depletion of mouse alpha beta T cell antigen receptor bearing lymphocytes by neonatal monoclonal antibody treatment by Mixter, PF, Sydora, BC, Hershberg, RM, Kronenberg, M

“…Neonatal treatment with a monoclonal antibody specific for the alpha beta TCR results in mice with a long term, severe depletion in the number of alpha beta T…”
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A Synthetic TLR4 Antagonist Has Anti-Inflammatory Effects in Two Murine Models of Inflammatory Bowel Disease by Fort, Madeline M, Mozaffarian, Afsaneh, Stover, Axel G, Correia, Jean da Silva, Johnson, David A, Crane, R. Thomas, Ulevitch, Richard J, Persing, David H, Bielefeldt-Ohmann, Helle, Probst, Peter, Jeffery, Eric, Fling, Steven P, Hershberg, Robert M

“…Current evidence indicates that the chronic inflammation observed in the intestines of patients with inflammatory bowel disease is due to an aberrant immune…”
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Taking toll: lipid A mimetics as adjuvants and immunomodulators by Persing, David H, Coler, Rhea N, Lacy, Michael J, Johnson, David A, Baldridge, Jory R, Hershberg, Robert M, Reed, Steven G

“…Vaccine adjuvants based on the structure of lipid A, such as monophosphoryl lipid A (MLA), have proven to be safe and effective in inducing immune responses to…”
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