Search Results - "Hersh, L. B."

Degradation of islet amyloid polypeptide by neprilysin by Guan, H., Chow, K. M., Shah, R., Rhodes, C. J., Hersh, L. B.

“…Aims/hypothesis A progressive loss of pancreatic beta cell function, a decrease in beta cell mass and accumulation of islet amyloid is characteristic of type 2…”
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The insulysin (insulin degrading enzyme) enigma by Hersh, L B

“…There are many cellular locations proposed for insulysin, yet there is a lack of a definitive study that clearly establishes within which cellular compartment…”
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Evidence for a deficit in cholinergic interneurons in the striatum in schizophrenia by Holt, D.J., Herman, M.M., Hyde, T.M., Kleinman, J.E., Sinton, C.M., German, D.C., Hersh, L.B., Graybiel, A.M., Saper, C.B.

“…Neurochemical and functional abnormalities of the striatum have been reported in schizophrenic brains, but the cellular substrates of these changes are not…”
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Insulysin Hydrolyzes Amyloid beta Peptides to Products That Are Neither Neurotoxic Nor Deposit on Amyloid Plaques by Mukherjee, Atish, Song, Eun-suk, Kihiko-Ehmann, Muthoni, Goodman, Jack P., Jr, Pyrek, Jan St, Estus, Steven, Hersh, Louis B

“…Insulysin (EC. 3.4.22.11) has been implicated in the clearance of beta amyloid peptides through hydrolytic cleavage. To further study the action of insulysin…”
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Quantification of cholinergic and select non-cholinergic mesopontine neuronal populations in the human brain by Manaye, K.F, Zweig, R, Wu, D, Hersh, L.B, De Lacalle, S, Saper, C.B, German, D.C

“…The pars compacta and pars dissipata of the pedunculopontine nucleus contain cholinergic cell group Ch5, and the laterodorsal tegmental nucleus contains…”
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Selective age-related loss of CALBINDIN-D28k from basal forebrain cholinergic neurons in the common marmoset (Callithrix jacchus) by WU, C.-K, NAGYKERY, N, HERSH, L. B, SCINTO, L. F. M, GEULA, C

“…A significant number of the cholinergic neurons in the basal forebrain of the primate, but not the rodent brain contain the calcium binding protein…”
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The hydrolysis of endothelins by neutral endopeptidase 24.11 (enkephalinase) by VIJAYARAGHAVAN, J, SCICLI, A. G, CARRETERO, O. A, SLAUGHTER, C, MOOMAW, C, HERSH, L. B

“…Endothelins 1-3 are a family of 21-amino acid peptides whose structure consists of two rings formed by intra-chain disulfide bonds and a linear "COOH-terminal…”
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CD10/Neutral Endopeptidase 24.11 Hydrolyzes Bombesin-Like Peptides and Regulates the Growth of Small Cell Carcinomas of the Lung by Shipp, Margaret A., Tarr, George E., Chen, Chang-Yan, Switzer, Stephanie N., Hersh, Louis B., Stein, Harald, Sunday, Mary E., Reinherz, Ellis L.

“…Bombesin-like peptides are essential autocrine growth factors for many small cell carcinomas (SCCas) of the lung. Herein, we demonstrate that these malignant…”
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An atlas of the regional and laminar distribution of choline acetyltransferase immunoreactivity in rat cerebral cortex by Lysakowski, A, Wainer, B H, Bruce, G, Hersh, L B

“…The distribution of cholinergic fibers in rat cortex was investigated using choline acetyl-transferase immunohistochemistry. Previous studies have either shown…”
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Common Acute Lymphoblastic Leukemia Antigen (CALLA) is Active Neutral Endopeptidase 24.11 (``Enkephalinase''): Direct Evidence by cDNA Transfection Analysis by Shipp, Margaret A., Vijayaraghavan, Jayanthi, Schmidt, Emmett V., Masteller, Emma L., D'Adamio, Luciano, Hersh, Louis B., Reinherz, Ellis L.

“…The common acute lymphoblastic leukemia antigen (CALLA) is a 749-amino acid type II integral membrane protein expressed by most acute lymphoblastic leukemias,…”
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Cholinergic innervation in the human striatum : A three-compartment model by HOLT, D. J, HERSH, L. B, SAPER, C. B

“…The mammalian striatum is divided into compartments that are anatomically and neurochemically distinct. The dorsal striatum has been described as containing…”
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Mesopontine cholinergic and non-cholinergic neurons in schizophrenia by German, D.C, Manaye, K.F, Wu, D, Hersh, L.B, Zweig, R.M

“…Mesopontine cholinergic neurons influence midbrain dopaminergic neurons, and thalamic and cerebellar structures which have been implicated in the neuroanatomy…”
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Heterogeneity and selectivity of the degeneration of cholinergic neurons in the basal forebrain of patients with Alzheimer's disease by Lehéricy, S, Hirsch, E C, Cervera-Piérot, P, Hersh, L B, Bakchine, S, Piette, F, Duyckaerts, C, Hauw, J J, Javoy-Agid, F, Agid, Y

“…Cholinergic neurons were studied by immunohistochemistry, with an antiserum against choline acetyltransferase (ChAT), in the basal forebrain (Ch1 to Ch4) of…”
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Mesencephalic cholinergic nuclei in progressive supranuclear palsy by JUNCOS, J. L, HIRSCH, E. C, MALESSA, S, DUYCKAERTS, C, HERSH, L. B, AGID, Y

“…Using an antibody against choline acetyltransferase (ChAT), mesencephalic cholinergic cell nuclei were studied in autopsy material from 3 cases of progressive…”
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Neprilysin Gene Transfer Reduces Human Amyloid Pathology in Transgenic Mice by Marr, Robert A, Rockenstein, Edward, Mukherjee, Atish, Kindy, Mark S, Hersh, Louis B, Gage, Fred H, Verma, Inder M, Masliah, Eliezer

“…The degenerative process of Alzheimer's disease is linked to a shift in the balance between amyloid-beta (Abeta) production, clearance, and degradation…”
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Differential cholinergic innervation within functional subdivisions of the human cerebral cortex: a choline acetyltransferase study by Mesulam, M M, Hersh, L B, Mash, D C, Geula, C

“…The distribution of cholinergic fibers in the human brain was investigated with choline acetyltransferase immunocytochemistry in 35 cytoarchitectonic…”
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The Cholinergic Gene Locus Is Coordinately Regulated by Protein Kinase A II in PC12 Cells by Shimojo, Masahito, Wu, Donghai, Hersh, Louis B.

“…: The vesicular acetylcholine transporter (VAChT) gene and the choline acetyltransferase (ChAT) gene comprise the cholinergic gene locus. We have studied the…”
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Patterns of direct projections from the hippocampus to the medial septum-diagonal band complex: anterograde tracing with Phaseolus vulgaris leucoagglutinin combined with immunohistochemistry of choline acetyltransferase by Gaykema, R P, van der Kuil, J, Hersh, L B, Luiten, P G

“…The projections from the Ammon's horn to the cholinergic cell groups in the medial septal and diagonal band nuclei were investigated with anterograde tracing…”
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Expression of meprin subunit precursors. Membrane anchoring through the beta subunit and mechanism of zymogen activation by JOHNSON, G. D, HERSH, L. B

“…The biosynthesis of the membrane-bound metalloendopeptidase meprin was studied after the introduction of cDNAs encoding the rat meprin alpha and beta subunits…”
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Selective Loss of Cholinergic Neurons in the Ventral Striatum of Patients with Alzheimer Disease by Lehéricy, Stéphane, Hirsch, Etienne C., Cervera, Pascale, Hersh, Louis B., Hauw, Jean-Jacques, Ruberg, Merle, Agid, Yves

“…Cholinergic neurons were studied by immunohistochemistry with an antiserum against human choline acetyltransferase in the caudate nucleus, putamen, and ventral…”
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