Search Results - "Hersey, P."

Five-year survival outcomes for patients with advanced melanoma treated with pembrolizumab in KEYNOTE-001 by Hamid, O., Robert, C., Daud, A., Hodi, F.S., Hwu, W.J., Kefford, R., Wolchok, J.D., Hersey, P., Joseph, R., Weber, J.S., Dronca, R., Mitchell, T.C., Patnaik, A., Zarour, H.M., Joshua, A.M., Zhao, Q., Jensen, E., Ahsan, S., Ibrahim, N., Ribas, A.

“…Pembrolizumab demonstrated robust antitumor activity and safety in the phase Ib KEYNOTE-001 study (NCT01295827) of advanced melanoma. Five-year outcomes in all…”
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An overview of regional and local characteristics of aerosols in South Africa using satellite, ground, and modeling data by Hersey, S P, Garland, R M, Crosbie, E, Shingler, T, Sorooshian, A, Piketh, S, Burger, R

“…We present a comprehensive overview of particulate air quality across the five major metropolitan areas of South Africa (Cape Town, Bloemfontein, Johannesburg…”
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Secondary organic aerosol formation from biomass burning intermediates: phenol and methoxyphenols by Yee, L. D, Kautzman, K. E, Loza, C. L, Schilling, K. A, Coggon, M. M, Chhabra, P. S, Chan, M. N, Chan, A. W. H, Hersey, S. P, Crounse, J. D, Wennberg, P. O, Flagan, R. C, Seinfeld, J. H

“…The formation of secondary organic aerosol from oxidation of phenol, guaiacol (2-methoxyphenol), and syringol (2,6-dimethoxyphenol), major components of…”
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Reactive intermediates revealed in secondary organic aerosol formation from isoprene by Surratt, Jason D, Chan, Arthur W.H, Eddingsaas, Nathan C, Chan, ManNin, Loza, Christine L, Kwan, Alan J, Hersey, Scott P, Flagan, Richard C, Wennberg, Paul O, Seinfeld, John H

“…Isoprene is a significant source of atmospheric organic aerosol; however, the oxidation pathways that lead to secondary organic aerosol (SOA) have remained…”
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Chemical Composition of Gas- and Aerosol-Phase Products from the Photooxidation of Naphthalene by Kautzman, K. E, Surratt, J. D, Chan, M. N, Chan, A. W. H, Hersey, S. P, Chhabra, P. S, Dalleska, N. F, Wennberg, P. O, Flagan, R. C, Seinfeld, J. H

“…The current work focuses on the detailed evolution of the chemical composition of both the gas- and aerosol-phase constituents produced from the OH-initiated…”
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Management of early melanoma recurrence despite adjuvant anti-PD-1 antibody therapy by Owen, C.N., Shoushtari, A.N., Chauhan, D., Palmieri, D.J., Lee, B., Rohaan, M.W., Mangana, J., Atkinson, V., Zaman, F., Young, A., Hoeller, C., Hersey, P., Dummer, R., Khattak, M.A., Millward, M., Patel, S.P., Haydon, A., Johnson, D.B., Lo, S., Blank, C.U., Sandhu, S., Carlino, M.S., Larkin, J.M.G., Menzies, A.M., Long, G.V.

“…Anti-programmed cell death protein 1 (PD-1) antibodies (PD1) prolong recurrence-free survival in high-risk resected melanoma; however, approximately 25%–30% of…”
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The Pasadena Aerosol Characterization Observatory (PACO): chemical and physical analysis of the Western Los Angeles basin aerosol by Hersey, S. P., Craven, J. S., Schilling, K. A., Metcalf, A. R., Sorooshian, A., Chan, M. N., Flagan, R. C., Seinfeld, J. H.

“…The Pasadena Aerosol Characterization Observatory (PACO) represents the first major aerosol characterization experiment centered in the Western/Central Los…”
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Biomarkers in melanoma by Gogas, H., Eggermont, A. M. M., Hauschild, A., Hersey, P., Mohr, P., Schadendorf, D., Spatz, A., Dummer, R.

“…Biomarkers are tumour- or host-related factors that correlate with tumour biological behaviour and patient prognosis. High-throughput analytical techniques—DNA…”
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Small molecules and targeted therapies in distant metastatic disease by Hersey, P., Bastholt, L., Chiarion-Sileni, V., Cinat, G., Dummer, R., Eggermont, A. M. M., Espinosa, E., Hauschild, A., Quirt, I., Robert, C., Schadendorf, D.

“…Chemotherapy, biological agents or combinations of both have had little impact on survival of patients with metastatic melanoma. Advances in understanding the…”
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Apoptosis of human melanoma cells induced by inhibition of B-RAFV600E involves preferential splicing of bimS by Jiang, C C, Lai, F, Tay, K H, Croft, A, Rizos, H, Becker, T M, Yang, F, Liu, H, Thorne, R F, Hersey, P, Zhang, X D

“…Bim is known to be critical in killing of melanoma cells by inhibition of the RAF/MEK/ERK pathway. However, the potential role of the most potent…”
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On the link between ocean biota emissions, aerosol, and maritime clouds: Airborne, ground, and satellite measurements off the coast of California by Sorooshian, Armin, Padró, Luz T., Nenes, Athanasios, Feingold, Graham, McComiskey, Allison, Hersey, Scott P., Gates, Harmony, Jonsson, Haflidi H., Miller, Steven D., Stephens, Graeme L., Flagan, Richard C., Seinfeld, John H.

“…Surface, airborne, and satellite measurements over the eastern Pacific Ocean off the coast of California during the period between 2005 and 2007 are used to…”
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Impact of a large wildfire on water-soluble organic aerosol in a major urban area: the 2009 Station Fire in Los Angeles County by Wonaschütz, A., Hersey, S. P., Sorooshian, A., Craven, J. S., Metcalf, A. R., Flagan, R. C., Seinfeld, J. H.

“…This study examines the nature of water-soluble organic aerosol measured in Pasadena, CA, under typical conditions and under the influence of a large wildfire…”
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Repression of microRNA-768-3p by MEK/ERK signalling contributes to enhanced mRNA translation in human melanoma by Jiang, C C, Croft, A, Tseng, H-Y, Guo, S T, Jin, L, Hersey, P, Zhang, X D

“…Increased global protein synthesis and selective translation of mRNAs encoding proteins contributing to malignancy is common in cancer cells. This is often…”
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Ets-1 mediates upregulation of Mcl-1 downstream of XBP-1 in human melanoma cells upon ER stress by Dong, L, Jiang, C C, Thorne, R F, Croft, A, Yang, F, Liu, H, de Bock, C E, Hersey, P, Zhang, X D

“…Past studies have shown that upregulation of the anti-apoptotic Bcl-2 family protein Mcl-1 is a major adaptive mechanism of melanoma cells to endoplasmic…”
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Use of the skin pinch test before elective caesarean section by Hersey, P., Gibb, S., Thomas, S.

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Repression of microRNA-768-3p by MEK/ERK signalling contributes to enhanced mRNA translation in human melanoma by Jiang, C C, Croft, A, Tseng, H-Y, Guo, S T, Jin, L, Hersey, P, Zhang, X D

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Immunotherapy of distant metastatic disease by Schadendorf, D., Algarra, S. M., Bastholt, L., Cinat, G., Dreno, B., Eggermont, A. M. M., Espinosa, E., Guo, J., Hauschild, A., Petrella, T., Schachter, J., Hersey, P.

“…Immunotherapy of metastatic melanoma consists of various approaches leading to specific or non-specific immunomodulation. The use of FDA-approved interleukin…”
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Societal preference values for advanced melanoma health states in the United Kingdom and Australia by Beusterien, K M, Szabo, S M, Kotapati, S, Mukherjee, J, Hoos, A, Hersey, P, Middleton, M R, Levy, A R

“…Background: No studies measure preference-based utilities in advanced melanoma that capture both intended clinical response and unintended toxicities…”
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Cystatin B inhibition of TRAIL-induced apoptosis is associated with the protection of FLIPL from degradation by the E3 ligase itch in human melanoma cells by Yang, F, Tay, K H, Dong, L, Thorne, R F, Jiang, C C, Yang, E, Tseng, H-Y, Liu, H, Christopherson, R, Hersey, P, Zhang, X D

“…Past studies have identified a number of distinct mechanisms that contribute to the resistance of melanoma cells against apoptosis induced by TNF-related…”
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Aerosol hygroscopicity in the marine atmosphere: a closure study using high-time-resolution, multiple-RH DASH-SP and size-resolved C-ToF-AMS data by Hersey, S. P., Sorooshian, A., Murphy, S. M., Flagan, R. C., Seinfeld, J. H.

“…We have conducted the first airborne hygroscopic growth closure study to utilize data from an Aerodyne compact Time-of-Flight Aerosol Mass Spectrometer…”
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