Search Results - "Herschman, Harvey R."

A Tumor Agnostic Therapeutic Strategy for Hexokinase 1-Null/Hexokinase 2-Positive Cancers by Xu, Shili, Herschman, Harvey R

“…Since Warburg's observation that most cancers exhibit elevated glycolysis, decades of research have attempted to reduce tumor glucose utilization as a…”
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Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche by Roulis, Manolis, Kaklamanos, Aimilios, Schernthanner, Marina, Bielecki, Piotr, Zhao, Jun, Kaffe, Eleanna, Frommelt, Laura-Sophie, Qu, Rihao, Knapp, Marlene S., Henriques, Ana, Chalkidi, Niki, Koliaraki, Vasiliki, Jiao, Jing, Brewer, J. Richard, Bacher, Maren, Blackburn, Holly N., Zhao, Xiaoyun, Breyer, Richard M., Aidinis, Vassilis, Jain, Dhanpat, Su, Bing, Herschman, Harvey R., Kluger, Yuval, Kollias, George, Flavell, Richard A.

“…The initiation of an intestinal tumour is a probabilistic process that depends on the competition between mutant and normal epithelial stem cells in crypts 1 …”
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Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 signaling by Li, Hua-Jung, Reinhardt, Ferenc, Herschman, Harvey R, Weinberg, Robert A

“…Mesenchymal cells of the tumor-associated stroma are critical determinants of carcinoma cell behavior. We focus here on interactions of carcinoma cells with…”
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Molecular Imaging: Looking at Problems, Seeing Solutions by Herschman, Harvey R.

“…Noninvasive molecular-imaging technologies are providing researchers with exciting new opportunities to study small-animal models of human disease. With…”
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Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-κB and NFAT transcriptional pathways by Kirkby, Nicholas S., Chan, Melissa V., Zaiss, Anne K., Garcia-Vaz, Eliana, Jiao, Jing, Berglund, Lisa M., Verdu, Elena F., Ahmetaj-Shala, Blerina, Wallace, John L., Herschman, Harvey R., Gomez, Maria F., Mitchell, Jane A.

“…Cyclooxygenase-2 (COX-2) is an inducible enzyme that drives inflammation and is the therapeutic target for widely used nonsteroidal antiinflammatory drugs…”
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Target identification using drug affinity responsive target stability (DARTS) by Lomenick, Brett, Hao, Rui, Jonai, Nao, Chin, Randall M, Aghajan, Mariam, Warburton, Sarah, Wang, Jianing, Wu, Raymond P, Gomez, Fernando, Loo, Joseph A, Wohlschlegel, James A, Vondriska, Thomas M, Pelletier, Jerry, Herschman, Harvey R, Clardy, Jon, Clarke, Catherine F, Huang, Jing

“…Identifying the molecular targets for the beneficial or detrimental effects of small-molecule drugs is an important and currently unmet challenge. We have…”
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Intestinal myofibroblast-specific Tpl2-Cox-2-PGE₂ pathway links innate sensing to epithelial homeostasis by Roulis, Manolis, Nikolaou, Christoforos, Kotsaki, Elena, Kaffe, Eleanna, Karagianni, Niki, Koliaraki, Vasiliki, Salpea, Klelia, Ragoussis, Jiannis, Aidinis, Vassilis, Martini, Eva, Becker, Christoph, Herschman, Harvey R, Vetrano, Stefania, Danese, Silvio, Kollias, George

“…Tumor progression locus-2 (Tpl2) kinase is a major inflammatory mediator in immune cell types recently found to be genetically associated with inflammatory…”
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The influence of innate and pre-existing immunity on adenovirus therapy by Zaiss, Anne K., Machado, Hidevaldo B., Herschman, Harvey R.

“…Recombinant adenovirus serotype 5 (Ad5) vectors have been studied extensively in preclinical gene therapy models and in a range of clinical trials. However,…”
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Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies by Kirkby, Nicholas S., Zaiss, Anne K., Wright, William R., Jiao, Jing, Chan, Melissa V., Warner, Timothy D., R. Herschman, Harvey, Mitchell, Jane A.

“…•We report interactions of Toll-like receptors (TLRs) with COX enzymes in vivo.•COX-2 was broadly induced by LPS (TLR4) but more locally by poly(I:C)…”
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[18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity by Kim, Woosuk, Le, Thuc M., Wei, Liu, Poddar, Soumya, Bazzy, Jimmy, Wang, Xuemeng, Uong, Nhu T., Abt, Evan R., Capri, Joseph R., Austin, Wayne R., Van Valkenburgh, Juno S., Steele, Dalton, Gipson, Raymond M., Slavik, Roger, Cabebe, Anthony E., Taechariyakul, Thotsophon, Yaghoubi, Shahriar S., Lee, Jason T., Sadeghi, Saman, Lavie, Arnon, Faull, Kym F., Witte, Owen N., Donahue, Timothy R., Phelps, Michael E., Herschman, Harvey R., Herrmann, Ken, Czernin, Johannes, Radu, Caius G.

“…Deoxycytidine kinase (dCK), a rate-limiting enzyme in the cytosolic deoxyribonucleoside (dN) salvage pathway, is an important therapeutic and positron emission…”
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Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors by Escuin-Ordinas, Helena, Li, Shuoran, Xie, Michael W., Sun, Lu, Hugo, Willy, Huang, Rong Rong, Jiao, Jing, de-Faria, Felipe Meira, Realegeno, Susan, Krystofinski, Paige, Azhdam, Ariel, Komenan, Sara Marie D., Atefi, Mohammad, Comin-Anduix, Begoña, Pellegrini, Matteo, Cochran, Alistair J., Modlin, Robert L., Herschman, Harvey R., Lo, Roger S., McBride, William H., Segura, Tatiana, Ribas, Antoni

“…BRAF inhibitors are highly effective therapies for the treatment of BRAF V600 -mutated melanoma, with the main toxicity being a variety of hyperproliferative…”
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ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways by Le, Thuc M., Poddar, Soumya, Capri, Joseph R., Abt, Evan R., Kim, Woosuk, Wei, Liu, Uong, Nhu T., Cheng, Chloe M., Braas, Daniel, Nikanjam, Mina, Rix, Peter, Merkurjev, Daria, Zaretsky, Jesse, Kornblum, Harley I., Ribas, Antoni, Herschman, Harvey R., Whitelegge, Julian, Faull, Kym F., Donahue, Timothy R., Czernin, Johannes, Radu, Caius G.

“…Leukemia cells rely on two nucleotide biosynthetic pathways, de novo and salvage, to produce dNTPs for DNA replication. Here, using metabolomic, proteomic, and…”
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Increased lysis of stem cells but not their differentiated cells by natural killer cells; de-differentiation or reprogramming activates NK cells by Tseng, Han-Ching, Arasteh, Aida, Paranjpe, Avina, Teruel, Antonia, Yang, Wendy, Behel, Armin, Alva, Jackelyn A, Walter, Gina, Head, Christian, Ishikawa, Tomo-o, Herschman, Harvey R, Cacalano, Nicholas, Pyle, April D, Park, No-Hee, Jewett, Anahid

“…The aims of this study are to demonstrate the increased lysis of stem cells but not their differentiated counterparts by the NK cells and to determine whether…”
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Exosomal 2′,3′‐CNP from mesenchymal stem cells promotes hippocampus CA1 neurogenesis/neuritogenesis and contributes to rescue of cognition/learning deficiencies of damaged brain by Chen, Shih‐Yin, Lin, Meng‐chieh, Tsai, Jia‐Shiuan, He, Pei‐Lin, Luo, Wen‐Ting, Chiu, Ing‐Ming, Herschman, Harvey R., Li, Hua‐Jung

“…Mesenchymal stem cells (MSCs) have been used in clinical studies to treat neurological diseases and damage. However, implanted MSCs do not achieve their…”
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Synaptotagmin IV determines the linear Ca2+ dependence of vesicle fusion at auditory ribbon synapses by Johnson, Stuart L, Franz, Christoph, Kuhn, Stephanie, Furness, David N, Rüttiger, Lukas, Münkner, Stefan, Rivolta, Marcelo N, Seward, Elizabeth P, Herschman, Harvey R, Engel, Jutta, Knipper, Marlies, Marcotti, Walter

“…Mammalian cochlea inner hair cells (IHCs) can code a continuous grading of sound intensities. This is because neurotransmitter release at mature sensory ribbon…”
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LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression by Kirkby, Nicholas S, Zaiss, Anne K, Urquhart, Paula, Jiao, Jing, Austin, Philip J, Al-Yamani, Malak, Lundberg, Martina H, MacKenzie, Louise S, Warner, Timothy D, Nicolaou, Anna, Herschman, Harvey R, Mitchell, Jane A

“…There are two schools of thought regarding the cyclooxygenase (COX) isoform active in the vasculature. Using urinary prostacyclin markers some groups have…”
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Adiponectin Promotes Revascularization of Ischemic Muscle through a Cyclooxygenase 2-Dependent Mechanism by Ohashi, Koji, Ouchi, Noriyuki, Sato, Kaori, Higuchi, Akiko, Ishikawa, Tomo-o, Herschman, Harvey R., Kihara, Shinji, Walsh, Kenneth

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The spatiotemporal role of COX-2 in osteogenic and chondrogenic differentiation of periosteum-derived mesenchymal progenitors in fracture repair by Huang, Chunlan, Xue, Ming, Chen, Hongli, Jiao, Jing, Herschman, Harvey R, O'Keefe, Regis J, Zhang, Xinping

“…Periosteum provides a major source of mesenchymal progenitor cells for bone fracture repair. Combining cell-specific targeted Cox-2 gene deletion approaches…”
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Development and Application of FASA, a Model for Quantifying Fatty Acid Metabolism Using Stable Isotope Labeling by Argus, Joseph P., Wilks, Moses Q., Zhou, Quan D., Hsieh, Wei Yuan, Khialeeva, Elvira, Hoi, Xen Ping, Bui, Viet, Xu, Shili, Yu, Amy K., Wang, Eric S., Herschman, Harvey R., Williams, Kevin J., Bensinger, Steven J.

“…It is well understood that fatty acids can be synthesized, imported, and modified to meet requisite demands in cells. However, following the movement of fatty…”
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Micro-PET imaging and small animal models of disease by Herschman, Harvey R

“…Positron emission tomography (PET) has been used clinically to measure enzyme reactions, ligand–receptor interactions, cellular metabolism and cell…”
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