Search Results - "Hersch, Steven J."

EF-P dependent pauses integrate proximal and distal signals during translation by Elgamal, Sara, Katz, Assaf, Hersch, Steven J, Newsom, David, White, Peter, Navarre, William Wiley, Ibba, Michael

“…Elongation factor P (EF-P) is required for the efficient synthesis of proteins with stretches of consecutive prolines and other motifs that would otherwise…”
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Engineered Type Six Secretion Systems Deliver Active Exogenous Effectors and Cre Recombinase by Hersch, Steven J, Lam, Linh, Dong, Tao G

“…Genetic editing has revolutionized biotechnology, but delivery of endonuclease genes as DNA can lead to aberrant integration or overexpression, leading to…”
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Differential Cellular Response to Translocated Toxic Effectors and Physical Penetration by the Type VI Secretion System by Kamal, Fatima, Liang, Xiaoye, Manera, Kevin, Pei, Tong-Tong, Kim, Haeun, Lam, Linh G., Pun, Alexander, Hersch, Steven J., Dong, Tao G.

“…The type VI secretion system (T6SS) is a lethal microbial weapon that injects a large needle-like structure carrying toxic effectors into recipient cells…”
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Manufacturing DNA in E. coli yields higher-fidelity DNA than in vitro enzymatic synthesis by Hersch, Steven J., Chandrasekaran, Siddarth, Lam, Jamie, Nafissi, Nafiseh, Slavcev, Roderick A.

“…Biotechnologies such as gene therapy have brought DNA vectors to the forefront of pharmaceuticals. The quality of starting material plays a pivotal role in…”
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Divergent protein motifs direct elongation factor P-mediated translational regulation in Salmonella enterica and Escherichia coli by Hersch, Steven J, Wang, Mengchi, Zou, S Betty, Moon, Kyung-Mee, Foster, Leonard J, Ibba, Michael, Navarre, William Wiley

“…Elongation factor P (EF-P) is a universally conserved bacterial translation factor homologous to eukaryotic/archaeal initiation factor 5A. In Salmonella,…”
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Loss of Elongation Factor P Disrupts Bacterial Outer Membrane Integrity by Zou, S. Betty, Hersch, Steven J, Roy, Hervé, Wiggers, J. Brad, Leung, Andrea S, Buranyi, Stephen, Xie, Jinglin Lucy, Dare, Kiley, Ibba, Michael, Navarre, William Wiley

“…Elongation factor P (EF-P) is posttranslationally modified at a conserved lysyl residue by the coordinated action of two enzymes, PoxA and YjeK. We have…”
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The Salmonella LysR Family Regulator RipR Activates the SPI-13-Encoded Itaconate Degradation Cluster by Hersch, Steven J, Navarre, William Wiley

“…Itaconate is a dicarboxylic acid that inhibits the isocitrate lyase enzyme of the bacterial glyoxylate shunt. Activated macrophages have been shown to produce…”
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Defending against the Type Six Secretion System: beyond Immunity Genes by Hersch, Steven J., Manera, Kevin, Dong, Tao G.

“…The bacterial type six secretion system (T6SS) delivers toxic effector proteins into neighboring cells, but bacteria must protect themselves against their own…”
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Stress-Induced Block in Dicarboxylate Uptake and Utilization in Salmonella enterica Serovar Typhimurium by Hersch, Steven J, Radan, Bojana, Ilyas, Bushra, Lavoie, Patrick, Navarre, William Wiley

“…Bacteria have evolved to sense and respond to their environment by altering gene expression and metabolism to promote growth and survival. In this work, we…”
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Translation Initiation Rate Determines the Impact of Ribosome Stalling on Bacterial Protein Synthesis by Hersch, Steven J., Elgamal, Sara, Katz, Assaf, Ibba, Michael, Navarre, William Wiley

“…Ribosome stalling during translation can be caused by a number of characterized mechanisms. However, the impact of elongation stalls on protein levels is…”
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Sensing of intracellular Hcp levels controls T6SS expression in Vibrio cholerae by Manera, Kevin, Caro, Florence, Li, Hao, Pei, Tong-Tong, Hersch, Steven J., Mekalanos, John J., Dong, Tao G.

“…The type 6 secretion system (T6SS) is a bacterial weapon broadly distributed in gram-negative bacteria and used to kill competitors and predators. Featuring a…”
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Envelope stress responses defend against type six secretion system attacks independently of immunity proteins by Hersch, Steven J., Watanabe, Nobuhiko, Stietz, Maria Silvina, Manera, Kevin, Kamal, Fatima, Burkinshaw, Brianne, Lam, Linh, Pun, Alexander, Li, Meixin, Savchenko, Alexei, Dong, Tao G.

“…The arms race among microorganisms is a key driver in the evolution of not only the weapons but also defence mechanisms. Many Gram-negative bacteria use the…”
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(R)-β-Lysine-modified Elongation Factor P Functions in Translation Elongation by Bullwinkle, Tammy J., Zou, S. Betty, Rajkovic, Andrei, Hersch, Steven J., Elgamal, Sara, Robinson, Nathaniel, Smil, David, Bolshan, Yuri, Navarre, William Wiley, Ibba, Michael

“…Post-translational modification of bacterial elongation factor P (EF-P) with (R)-β-lysine at a conserved lysine residue activates the protein in vivo and…”
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A lightweight, mechanically strong, and shapeable copper-benzenedicarboxylate/cellulose aerogel for dye degradation and antibacterial applications by Ren, Yuxuan, Hersch, Steven J., He, Xiao, Zhou, Rufan, Dong, Tao G., Lu, Qingye

“…[Display omitted] •CuBDC nanosheets were loaded on cellulose aerogels by in-situ growth.•The composite aerogel showed good performance in degradation of…”
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A stress-induced block in dicarboxylate uptake and utilization in Salmonella by Hersch, Steven J, Radan, Bojana, Ilyas, Bushra, Lavoie, Patrick, Navarre, William Wiley

“…Bacteria have evolved to sense and respond to their environment by altering gene expression and metabolism to promote growth and survival. In this work we…”
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EF-P Dependent Pauses Integrate Proximal and Distal Signals during Translation: e1004553 by Elgamal, Sara, Katz, Assaf, Hersch, Steven J, Newsom, David, White, Peter, Navarre, William Wiley, Ibba, Michael

“…Elongation factor P (EF-P) is required for the efficient synthesis of proteins with stretches of consecutive prolines and other motifs that would otherwise…”
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Loss of Elongation Factor P Disrupts Bacterial Outer Membrane Integrity by Zou, S. Betty, Hersch, Steven J., Roy, Hervé, Wiggers, J. Brad, Leung, Andrea S., Buranyi, Stephen, Xie, Jinglin Lucy, Dare, Kiley, Ibba, Michael, Navarre, William Wiley

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