Search Results - "Herron, James N"
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Co-formulation of the rF1V plague vaccine with depot-formulated cytokines enhances immunogenicity and efficacy to elicit protective responses against aerosol challenge in mice
Published in Frontiers in immunology (28-03-2024)“…This study evaluated a depot-formulated cytokine-based adjuvant to improve the efficacy of the recombinant F1V (rF1V) plague vaccine and examined the…”
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The magnitude of the germinal center B cell and T follicular helper cell response predicts long-lasting antibody titers to plague vaccination
Published in Frontiers in immunology (28-10-2022)“…The development of a safe and effective vaccine against , the causative organism for plague disease, remains an important global health priority. Studies have…”
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Effect of a Pluronic® P123 Formulation on the Nitric Oxide-Generating Drug JS-K
Published in Pharmaceutical research (01-04-2015)“…ABSTRACT Purpose O 2 -(2,4-dinitrophenyl)1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate] or JS-K is a nitric oxide-producing prodrug of the…”
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Probing bis-ANS binding sites of different affinity on aggregated IgG by steady-state fluorescence, time-resolved fluorescence and isothermal titration calorimetry
Published in Journal of pharmaceutical sciences (01-04-2011)“…Fluorescent dyes, for example, 4,4'-dianilino-1,1'-binaphthyl-5,5'-disulfonic acid dipotassium salt (bis-ANS) are extensively used to detect nonnative protein…”
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In-Plane Parallel Scanning: A Microarray Technology for Point-of-Care Testing
Published in Analytical chemistry (Washington) (01-11-2010)“…A new microarray technology is described for rapid, inexpensive, multiplex diagnostics assays. Referred to as “in-plane parallel scanning” (IPPS), this…”
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Investigation of Specific Binding of Antifluorescyl Antibody and Fab to Fluorescein Lipids in Langmuir-Blodgett Deposited Films Using Quartz Crystal Microbalance Methodology
Published in Analytical chemistry (Washington) (15-05-1994)“…Antifluorescyl IgG antibody and Fab binding to two fluorescein-conjugated lipids was measured using the quartz crystal microbalance methodology. By use of the…”
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Rapid throughput solubility screening method for BCS class II drugs in animal GI fluids and simulated human GI fluids using a 96-well format
Published in Journal of pharmaceutical sciences (01-04-2008)“…A rapid solubility-screening assay was developed with a focus on Biopharmaceutic Classification Scheme (BCS) class II drug solubility in animal and simulated…”
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Optical system design for biosensors based on CCD detection
Published in Methods in molecular biology (Clifton, N.J.) (2009)“…The use of Charge Coupled Device (CCD) detectors as an integral part of a biosensing system has become widespread in recent years due to several advantages of…”
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A liposome permeability model for stratum corneum lipid bilayers based on commercial lipids
Published in Journal of pharmaceutical sciences (01-10-2008)“…The objective was to evaluate stratum corneum lipid liposomes (SCLLs) prepared from commercial lipids as a convenient model system for studying the mechanisms…”
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The role of protein charge in protein-lipid interactions. pH-Dependent changes of the electrophoretic mobility of liposomes through adsorption of water-soluble, globular proteins
Published in Biochemistry (Easton) (04-05-1993)“…The role of electrostatics in the adsorption process of proteins to preformed negatively-charged (phosphatidylcholine/phosphatidylglycerol) and neutral…”
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Micellar delivery of doxorubicin and its paramagnetic analog, ruboxyl, to HL-60 cells: effect of micelle structure and ultrasound on the intracellular drug uptake
Published in Journal of controlled release (29-03-1999)“…The effect of Pluronic P-105 micelle structure and ultrasound on the uptake of two anthracycline drugs, doxorubicin and its paramagnetic analogue, ruboxyl, by…”
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Poly(ethylene glycol) on the liposome surface: on the mechanism of polymer-coated liposome longevity
Published in Biochimica et biophysica acta (12-10-1994)“…The hypothetical model is built explaining the molecular mechanism of protective action of poly(ethylene glycol) on liposomes in vivo. The protective layer of…”
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Use of synthetic peptides as tracer antigens in fluorescence polarization immunoassays of high molecular weight analytes
Published in Analytical chemistry (Washington) (01-12-1993)“…This paper describes a homogeneous immunoassay based on fluorescence polarization that enables subnanomolar detection of high molecular weight analytes. A…”
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Rapid throughput screening of apparent KSP values for weakly basic drugs using 96-well format
Published in Journal of pharmaceutical sciences (01-06-2008)“…A rapid-throughput screening assay was developed to estimate the salt solubility parameter, K(SP), with a minimal quantity of drug. This assay allows for early…”
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Thermodynamic properties of ligand binding by monoclonal anti-fluorescyl antibodies
Published in Biochemistry (Easton) (01-08-1986)“…The effects of temperature on the binding of fluorescein by three monoclonal anti-fluorescyl antibodies (4-4-20, 20-19-1, and 20-20-3) were assessed by…”
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Photopatterning of Antibodies on Biosensors
Published in Bioconjugate chemistry (01-11-2000)“…The immobilization of biomolecules on surfaces in defined micropatterns has become increasingly important for the development of new diagnostic devices and…”
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Three-dimensional Structures of Idiotypically Related Fabs with Intermediate and High Affinity for Fluorescein
Published in Journal of molecular biology (18-06-2004)“…Multi-disciplinary studies of fluorescein–protein conjugates have led to the generation of a family of antibodies with common idiotypes and affinities for…”
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Single-chain polymorphism analysis in long QT syndrome using planar waveguide fluorescent biosensors
Published in Analytical biochemistry (15-04-2003)“…Rapid detection of single nucleotide polymorphisms (SNPs) has potential applications in both genetic screening and pharmacogenomics. Planar waveguide…”
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How well can an idiotope peptide mimic replace its parent idiotype in a synthetic peptide vaccine?
Published in Pharmaceutical research (01-08-2004)“…To determine whether a vaccine consisting of an idiotope peptide mimic of the third complementarity-determining region of the immunoglobulin heavy chain…”
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