Search Results - "Herron, CE"

Simvastatin increases excitability in the hippocampus via a PI3 kinase-dependent mechanism by Métais, C, Hughes, B, Herron, C.E

“…Highlights • Acute application of simvastatin increases the amplitude of the fEPSP in the CA1 of hippocampal slices from c57b6 mice. • Acute simvastatin…”
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Toxicokinetics and toxicity of atorvastatin in dogs by Herron, C.E., Brueckner, C.C., Chism, J.P., Kemp, D.C., Prescott, J.S., Smith, G.A., Melich, D.H., Oleas, N., Polli, J.W.

“…HMG-CoA reductase inhibitors (e.g., statins) are an important clinical option to lower cholesterol and treat co-morbidities. Atorvastatin is the most…”
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Blockade of long-term potentiation by beta-amyloid peptides in the CA1 region of the rat hippocampus in vivo by Freir, D B, Holscher, C, Herron, C E

“…The effect of intracerebroventricular (icv) injections of beta-amyloid peptide fragments Abeta[15-25], Abeta[25-35], and Abeta[35-25] were examined on synaptic…”
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Activation of the c-Jun N-terminal Kinase Signaling Cascade Mediates the Effect of Amyloid- beta on Long Term Potentiation and Cell Death in Hippocampus: A role for interleukin-1 beta ? by Minogue, A M, Schmid, A W, Fogarty, M P, Moore, A C, Campbell, V A, Herron, CE, Lynch, MA

“…Amyloid- beta (A beta ) is a major constituent of the neuritic plaque found in the brain of Alzheimer's disease patients, and a great deal of evidence suggests…”
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Inhibition of LTP in vivo by beta-amyloid peptide in different conformational states by Schmid, Adrien W, Freir, Darragh B, Herron, Caroline E

“…Abstract We have investigated changes in the morphological structure of Aβ1–40 during different incubation time periods at 37 °C ranging from 1 h to 7 days…”
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The role of c-Jun N-terminal kinase in the Aβ-mediated impairment of LTP and regulation of synaptic transmission in the hippocampus by Costello, Derek A., Herron, Caroline E.

“…The effects of the beta-amyloid peptide (Aβ) fragment 25–35 were investigated on hippocampal synaptic transmission and long-term potentiation (LTP) in vitro…”
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A role for the Ras signalling pathway in synaptic transmission and long-term memory by Klein, Rdiger, Brambilla, Riccardo, Gnesutta, Nerina, Minichiello, Liliana, White, Gail, Roylance, Alistair J, Herron, Caroline E, Ramsey, Mark, Wolfer, David P, Cestari, Vincenzo, Rossi-Arnaud, Clelia, Grant, Seth G. N, Chapman, Paul F, Lipp, Hans-Peter, Sturani, Emmapaola

“…Members of the Ras subfamily of small guanine-nucleotide-binding proteins are essential for controlling normal and malignant cell proliferation as well as cell…”
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Agonists of peroxisome proliferator-activated receptor-γ attenuate the Aβ-mediated impairment of LTP in the hippocampus in vitro by Costello, Derek A., O'Leary, Deirdre M., Herron, Caroline E.

“…The data we present here suggest that agonists of peroxisome proliferator-activated receptor-γ (PPARγ) can attenuate the effects of beta-amyloid peptide (Aβ)…”
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Inhibition of l-type voltage dependent calcium channels causes impairment of long-term potentiation in the hippocampal CA1 region in vivo by Freir, Darragh B., Herron, Caroline E.

“…Long-term potentiation (LTP), in the hippocampal CA1 region is dependent on postsynaptic calcium influx. It is generally accepted that calcium influx occurs…”
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An Essential Role for Protein Phosphatases in Hippocampal Long-Term Depression by Mulkey, Rosel M., Herron, Caroline E., Malenka, Robert C.

“…The effectiveness of long-term potentiation (LTP) as a mechanism for information storage would be severely limited if processes that decrease synaptic strength…”
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Nicotine Enhances the Depressive Actions of A beta sub(1-40) on Long-Term Potentiation in the Rat Hippocampal CA1 Region In Vivo by Freir, D B, Herron, CE

“…Hippocampal long-term potentiation (LTP) is a form of synaptic plasticity used as a cellular model of memory. Beta amyloid (A beta ) is involved in Alzheimer's…”
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A beta 25-35-induced depression of long-term potentiation in area CA1 in vivo and in vitro is attenuated by verapamil by Freir, D B, Costello, D A, Herron, C E

“…The effect of intracerebroventricular (icv) injection of A beta 25-35 and/or intraperitoneal (ip) application of the L-type calcium channel (VDCC) blockers…”
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Synaptic activation of N-methyl-D-aspartate receptors in the Schaffer collateral-commissural pathway of rat hippocampus by Collingridge, G L, Herron, C E, Lester, R A

“…1. The involvement of N-methyl-D-aspartate (NMDA) receptors in the response to single-shock (0.033 Hz) stimulation of the Schaffer collateral-commissural…”
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Frequency-dependent involvement of NMDA receptors in the hippocampus: a novel synaptic mechanism by Herron, Caroline E, Lester, Robin A. J, Coan, Elizabeth J, Collingridge, Graham L

“…Acidic amino acids, such as l-glutamate, are believed to be excitatory neurotransmitters in the mammalian brain and exert effects on several different…”
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Frequency-dependent N-methyl-D-aspartate receptor-mediated synaptic transmission in rat hippocampus by Collingridge, G L, Herron, C E, Lester, R A

“…1. The effects of the N-methyl-D-aspartate (NMDA) antagonist, D-2-amino-5-phosphonovalerate (APV) were examined on synaptic responses evoked by high-frequency…”
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Activity-dependent enhancement of synaptic transmission in hippocampal slices treated with the phosphatase inhibitor calyculin A by Herron, CE, Malenka, RC

“…The role of protein phosphatases in regulating synaptic transmission in the CA1 region of the hippocampus was examined using slices pretreated with calyculin…”
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A selective N-methyl-D-aspartate antagonist depresses epileptiform activity in rat hippocampal slices by Herron, C E, Williamson, R, Collingridge, G L

“…The sensitivity of convulsant-induced epileptiform activity in the hippocampus to the selective N-methyl-D-aspartate (NMDA) antagonist…”
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Intracellular demonstration of an N-methyl-D-aspartate receptor mediated component of synaptic transmission in the rat hippocampus by Herron, C E, Lester, R A, Coan, E J, Collingridge, G L

“…Rat hippocampal CA1 pyramidal neurones were monosynaptically activated via stimulation of the Schaffer collateral-commissural pathway. On changing from a 1 mM…”
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Voltage-clamp analysis of somatic gamma-aminobutyric acid responses in adult rat hippocampal CA1 neurones in vitro by Ashwood, T J, Collingridge, G L, Herron, C E, Wheal, H V

“…1. The response of CA1 pyramidal neurones to somatic application of gamma-aminobutyric acid (GABA) was studied in adult hippocampal slices using…”
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Hippocampal synaptic transmission: regulation of the NMDA receptor-mediated component by Herron, C E, Forsythe, I D

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