Search Results - "Herring, Jacob A."

Function of Nr4a Orphan Nuclear Receptors in Proliferation, Apoptosis and Fuel Utilization Across Tissues by Herring, Jacob A, Elison, Weston S, Tessem, Jeffery S

“…The Nr4a family of nuclear hormone receptors is composed of three members-Nr4a1/Nur77, Nr4a2/Nurr1 and Nr4a3/Nor1. While currently defined as ligandless, these…”
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Diversity and conservation of the genome architecture of phages infecting the Alphaproteobacteria by Hyde, Jonathan R, Armond, Thomas, Herring, Jacob A, Hope, Sandra, Grose, Julianne H, Breakwell, Donald P, Pickett, Brett E

“…This study reports the results of the largest analysis of genome sequences from phages that infect the Alphaproteobacteria class of bacterial hosts. We…”
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CEBPA Overexpression Enhances β-Cell Proliferation and Survival by Ellsworth, Peter N, Herring, Jacob A, Leifer, Aaron H, Ray, Jason D, Elison, Weston S, Poulson, Peter Daniel, Crabtree, Jacqueline E, Van Ry, Pam M, Tessem, Jeffery S

“…A commonality between type 1 and type 2 diabetes is the decline in functional β-cell mass. The transcription factor Nkx6.1 regulates β-cell development and is…”
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Loss of glucose-stimulated β-cell Nr4a1 expression impairs insulin secretion and glucose homeostasis by Herring, Jacob A, Crabtree, Jacqueline E, Hill, Jonathon T, Tessem, Jeffery S

“…A central aspect of type 2 diabetes is decreased functional β-cell mass. The orphan nuclear receptor Nr4a1 is critical for fuel utilization, but little is…”
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Potential of Phenolic Compounds and Their Gut Microbiota-Derived Metabolites to Reduce TMA Formation: Application of an In Vitro Fermentation High-Throughput Screening Model by Iglesias-Carres, Lisard, Krueger, Emily S, Herring, Jacob A, Tessem, Jeffery S, Neilson, Andrew P

“…Trimethylamine -oxide (TMAO) is a pro-atherosclerotic product of dietary choline metabolism generated by a microbiome-host axis. The first step in this pathway…”
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Cocoa extract exerts sex-specific anti-diabetic effects in an aggressive type-2 diabetes model: A pilot study by Racine, Kathryn C., Iglesias-Carres, Lisard, Herring, Jacob A., Ferruzzi, Mario G., Kay, Colin D., Tessem, Jeffery S., Neilson, Andrew P.

“…Type 2 diabetes (T2D) is characterized by hyperglycemia and insulin resistance. Cocoa may slow T2D development and progression. This study employed male and…”
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The high-fat diet and low-dose streptozotocin type-2 diabetes model induces hyperinsulinemia and insulin resistance in male but not female C57BL/6J mice by Racine, Kathryn C., Iglesias-Carres, Lisard, Herring, Jacob A., Wieland, Kristopher L., Ellsworth, Peter N., Tessem, Jeffery S., Ferruzzi, Mario G., Kay, Colin D., Neilson, Andrew P.

“…•Both sexes gained weight on high-fat (HF) diet + low-dose streptozotocin (STZ).•Both sexes developed impaired oral glucose tolerance.•Only males developed…”
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Common gut microbial metabolites of dietary flavonoids exert potent protective activities in β-cells and skeletal muscle cells by Bitner, Benjamin F., Ray, Jason D., Kener, Kyle B., Herring, Jacob A., Tueller, Josie A., Johnson, Deborah K., Tellez Freitas, Claudia M., Fausnacht, Dane W., Allen, Mitchell E., Thomson, Alexander H., Weber, K. Scott, McMillan, Ryan P., Hulver, Matthew W., Brown, David A., Tessem, Jeffery S., Neilson, Andrew P.

“…Flavonoids are dietary compounds with potential anti-diabetes activities. Many flavonoids have poor bioavailability and thus low circulating concentrations…”
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Identification of direct transcriptional targets of NFATC2 that promote β cell proliferation by Simonett, Shane P, Shin, Sunyoung, Herring, Jacob A, Bacher, Rhonda, Smith, Linsin A, Dong, Chenyang, Rabaglia, Mary E, Stapleton, Donnie S, Schueler, Kathryn L, Choi, Jeea, Bernstein, Matthew N, Turkewitz, Daniel R, Perez-Cervantes, Carlos, Spaeth, Jason, Stein, Roland, Tessem, Jeffery S, Kendziorski, Christina, Keleş, Sündüz, Moskowitz, Ivan P, Keller, Mark P, Attie, Alan D

“…The transcription factor NFATC2 induces β cell proliferation in mouse and human islets. However, the genomic targets that mediate these effects have not been…”
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Genome Sequences of Nine Erwinia amylovora Bacteriophages by Sharma, Ruchira, Berg, Jordan A, Beatty, Nolan J, Choi, Minsey C, Cowger, Ashlin E, Cozzens, Brooke J R, Duncan, Steven G, Fajardo, Christopher P, Ferguson, Hannah P, Galbraith, Trevon, Herring, Jacob A, Hoj, Taalin R, Durrant, Jill L, Hyde, Jonathan R, Jensen, Garrett L, Ke, Si Yang, Killpack, Shalee, Kruger, Jared L, Lawrence, Eliza E K, Nwosu, Ifeanyichukwu O, Tam, Tsz Ching, Thompson, Daniel W, Tueller, Josie A, Ward, Megan E H, Webb, Charles J, Wood, Madison E, Yeates, Edward L, Baltrus, David A, Breakwell, Donald P, Hope, Sandra, Grose, Julianne H

“…Erwinia amylovora is a plant pathogen belonging to the Enterobacteriaceae family, a family containing many plant and animal pathogens. Herein, we announce nine…”
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A High-fat Diet Causes Nr4a3-dependent Changes In Mitochondrial Respiration In Mouse Liver: 3861 Board #178 May 30 9:00 AM - 10:30 AM by Marchant, Erik D., Marchant, Nathan D., Elison, Weston S., Herring, Jacob A., Yang, Haokun, Tessem, Jeffrey S., Hancock, Chad R.

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High-fat Diet Induces Nr4a3-dependent Decrease In Respiratory Capacity Of Mouse Soleus Muscle: 3857 Board #174 May 30 9:00 AM - 10:30 AM by Marchant, Nathan D., Marchant, Erik D., Elison, Weston S., Herring, Jacob A., Yang, Haokun, Tessem, Jeffrey S., Hancock, Chad R.

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Gender specific effects of Nr4a1 on functional β‐cell mass by Herring, Jacob A., Smith, Courtney J., Kener, Kyle B., Wynn, Adam G., Austin, Matt C., Tessem, Jeffery Sivert

“…Nuclear hormone receptor4a1 (Nr4a1) plays a critical role in β‐cell replication, function, and survival. β‐cell replication is tightly regulated, most β‐cells…”
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Identification of direct transcriptional targets of NFATC2 that promote [beta] cell proliferation by Simonett, Shane P, Shin, Sunyoung, Herring, Jacob A, Bacher, Rhonda, Smith, Linsin A, Dong, Chenyang, Rabaglia, Mary E, Stapleton, Donnie S, Schueler, Kathryn L, Choi, Jeea, Bernstein, Matthew N, Turkewitz, Daniel R, Perez-Cervantes, Carlos, Spaeth, Jason, Stein, Roland, Tessem, Jeffery S, Kendziorski, Christina, Keles, Sunduz, Moskowitz, Ivan P, Keller, Mark P, Attie, Alan D

“…The transcription factor NFATC2 induces [beta] cell proliferation in mouse and human islets. However, the genomic targets that mediate these effects have not…”
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Effects of Epicatechin and its Gut Metabolites on Beta Cell Function, Survival and Proliferation by Tessem, Jeffery Sivert, Rowley, Thomas J., Ray, Jason D., Herring, Jacob A., Kener, Kyle B., Bitner, Benjamin F., Ross, Mimi, Lopez, Moroni, Bikman, Benjamin T., Neilson, Andrew P.

“…An initiating factor of Type 2 diabetes (T2D) is beta cell dysfunction and the eventual loss of functional beta cell mass. Mechanisms that improve beta cell…”
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