Search Results - "Herrera, Maria Beatriz"
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Human Liver Stem Cell-Derived Extracellular Vesicles Prevent Aristolochic Acid-Induced Kidney Fibrosis
Published in Frontiers in immunology (19-07-2018)“…With limited therapeutic intervention in preventing the progression to end-stage renal disease, chronic kidney disease (CKD) remains a global health-care…”
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Extracellular vesicles from human liver stem cells inhibit tumor angiogenesis
Published in International journal of cancer (15-01-2019)“…Human liver stem‐like cells (HLSC) and derived extracellular vesicles (EVs) were previously shown to exhibit anti‐tumor activity. In our study, we investigated…”
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Human Liver Stem Cell Derived Extracellular Vesicles Alleviate Kidney Fibrosis by Interfering with the β-Catenin Pathway through miR29b
Published in International journal of molecular sciences (01-10-2021)“…Human liver stem-cell-derived extracellular vesicles (HLSC-EVs) exhibit therapeutic properties in various pre-clinical models of kidney injury. We previously…”
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Mesenchymal Stem Cell Derived Extracellular Vesicles Ameliorate Kidney Injury in Aristolochic Acid Nephropathy
Published in Frontiers in cell and developmental biology (24-03-2020)“…Limitations in the current therapeutic strategies for the prevention of progression of chronic kidney disease (CKD) to end stage renal disease has been a…”
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Human Liver-Derived Stem Cells Improve Fibrosis and Inflammation Associated with Nonalcoholic Steatohepatitis
Published in Stem cells international (01-01-2019)“…Cell therapy may be regarded as a feasible alternative to whole organ transplantation to treat end-stage liver diseases. Human liver stem cells (HLSCs) are a…”
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Extracellular Vesicles as Delivery Vehicles for Non-Coding RNAs: Potential Biomarkers for Chronic Liver Diseases
Published in Biomolecules (Basel, Switzerland) (26-02-2024)“…In recent years, EVs have emerged as promising vehicles for coding and non-coding RNAs (ncRNAs), which have demonstrated remarkable potential as biomarkers for…”
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Extracellular vesicles from human liver stem cells restore argininosuccinate synthase deficiency
Published in Stem cell research & therapy (27-07-2017)“…Argininosuccinate synthase (ASS)1 is a urea cycle enzyme that catalyzes the conversion of citrulline and aspartate to argininosuccinate. Mutations in the ASS1…”
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Large-Scale Expansion of Human Liver Stem Cells Using Two Different Bioreactor Systems
Published in Bioengineering (Basel) (09-07-2024)“…The assessment of human liver stem cells (HLSCs) as cell therapeutics requires scalable, controlled expansion processes. We first focused on defining…”
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Extracellular Vesicles Derived from Human Liver Stem Cells Counteract Chronic Kidney Disease Development and Cardiac Dysfunction in Remnant Kidney Murine Model: The Possible Involvement of Proteases
Published in Biomedicines (08-07-2024)“…Fibrosis is a marker of chronic kidney disease (CKD) and consists of the accumulation of the extracellular matrix (ECM) components, causing the progressive…”
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Human liver stem cells express UGT1A1 and improve phenotype of immunocompromised Crigler Najjar syndrome type I mice
Published in Scientific reports (21-01-2020)“…Crigler Najjar Syndrome type I (CNSI) is a rare recessive disorder caused by mutations in the Ugt1a1 gene. There is no permanent cure except for liver…”
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HLSC-Derived Extracellular Vesicles Attenuate Liver Fibrosis and Inflammation in a Murine Model of Non-alcoholic Steatohepatitis
Published in Molecular therapy (05-02-2020)“…Extracellular vesicles (EVs) are membrane vesicles released virtually by all cell types. Several studies have shown that stem cell-derived EVs may mimic both…”
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Isolation and Characterization of a Stem Cell Population from Adult Human Liver
Published in Stem cells (Dayton, Ohio) (01-12-2006)“…Several studies suggested the presence of stem cells in the adult normal human liver; however, a population with stem cell properties has not yet been…”
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Naïve or Engineered Extracellular Vesicles from Different Cell Sources: Therapeutic Tools for Kidney Diseases
Published in Pharmaceutics (01-06-2023)“…Renal pathophysiology is a multifactorial process involving different kidney structures. Acute kidney injury (AKI) is a clinical condition characterized by…”
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Human liver stem cell-derived extracellular vesicles modulate long non-coding RNA expression profile in an in vivo model of non-alcoholic steatohepatitis
Published in Exploration of digestive diseases (30-08-2023)“…Aim: Modifications in long non-coding RNA (lncRNA) expression are associated with inflammation and fibrosis in chronic liver diseases. It has been recently…”
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Human liver stem cells and derived extracellular vesicles improve recovery in a murine model of acute kidney injury
Published in Stem cell research & therapy (10-11-2014)“…Several cellular sources of stem cells have been tested in the attempt to yield innovative interventions in acute kidney injury (AKI). Human liver stem cells…”
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Recellularization of rat liver scaffolds by human liver stem cells
Published in Tissue engineering. Part A (01-06-2015)“…In the present study, rat liver acellular scaffolds were used as biological support to guide the differentiation of human liver stem-like cells (HLSC) to…”
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Intrahepatic Administration of Human Liver Stem Cells in Infants with Inherited Neonatal-Onset Hyperammonemia: A Phase I Study
Published in Stem cell reviews and reports (01-02-2020)“…Previous studies have shown that human liver stem-like cells (HLSCs) may undergo differentiation in vitro into urea producing hepatocytes and in vivo may…”
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iNOS activation regulates β-catenin association with its partners in endothelial cells
Published in PloS one (28-12-2012)“…Signals that disrupt β-catenin association to cadherins may influence the translocation of β-catenin to the nucleus to regulate transcription…”
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Emerging Cancer Immunotherapies: Cutting-Edge Advances and Innovations in Development
Published in Medical sciences (Basel) (28-08-2024)“…The rise in biological therapies has revolutionized oncology, with immunotherapy leading the charge through breakthroughs such as CAR-T cell therapy for…”
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Human Liver Stem Cells: A Liver-Derived Mesenchymal Stromal Cell-Like Population With Pro-regenerative Properties
Published in Frontiers in cell and developmental biology (26-04-2021)“…Human liver stem cells (HLSCs) were described for the first time in 2006 as a new stem cell population derived from healthy human livers. Like mesenchymal…”
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