Search Results - "Herranz, Hector"

MicroRNAs and gene regulatory networks: managing the impact of noise in biological systems by Herranz, Héctor, Cohen, Stephen M

“…Biological systems are continuously challenged by an environment that is variable. Yet, a key feature of developmental and physiological processes is their…”
Get full text

Oncogenic cooperation between SOCS family proteins and EGFR identified using a Drosophila epithelial transformation model by Herranz, Héctor, Hong, Xin, Hung, Nguyen Thanh, Voorhoeve, P Mathijs, Cohen, Stephen M

“…MicroRNAs (miRNAs) are emerging as cooperating factors that promote the activity of oncogenes in tumor formation and disease progression. This poses the…”
Get full text

Insulin signaling mediates neurodegeneration in glioma by Jarabo, Patricia, de Pablo, Carmen, Herranz, Héctor, Martín, Francisco Antonio, Casas-Tintó, Sergio

“…Cell to cell communication facilitates tissue development and physiology. Under pathological conditions, brain tumors disrupt glia-neuron communication signals…”
Get full text

Cancer in Drosophila: Imaginal Discs as a Model for Epithelial Tumor Formation by Herranz, Héctor, Eichenlaub, Teresa, Cohen, Stephen M

“…Cancer genomics has greatly increased our understanding of the complexity of the genetic and epigenetic changes found in human tumors. Understanding the…”
Get full text

The miRNA bantam regulates growth and tumorigenesis by repressing the cell cycle regulator tribbles by Gerlach, Stephan U, Sander, Moritz, Song, Shilin, Herranz, Héctor

“…One of the fundamental issues in biology is understanding how organ size is controlled. Tissue growth has to be carefully regulated to generate…”
Get full text

Cell Competition Drives the Formation of Metastatic Tumors in a Drosophila Model of Epithelial Tumor Formation by Eichenlaub, Teresa, Cohen, Stephen M., Herranz, Héctor

“…Cell competition is a homeostatic process in which proliferating cells compete for survival. Elimination of otherwise normal healthy cells through competition…”
Get full text

Genome-Wide Screen for Context-Dependent Tumor Suppressors Identified Using in Vivo Models for Neoplasia in Drosophila by Groth, Casper, Vaid, Pooja, Khatpe, Aditi, Prashali, Nelchi, Ahiya, Avantika, Andrejeva, Diana, Chakladar, Madhumita, Nagarkar, Sanket, Paul, Rachel, Kelkar, Devaki, Eichenlaub, Teresa, Herranz, Hector, Sridhar, T S, Cohen, Stephen M, Shashidhara, L S

“…Genetic approaches in have successfully identified many genes involved in regulation of growth control as well as genetic interactions relevant to the…”
Get full text

Gain-of-Function Suppressor Screen for Genes Involved in Dorsal-Ventral Boundary Formation in the Drosophila Wing by Bejarano, F, Luque, C.M, Herranz, H, Sorrosal, G, Rafel, N, Pham, T.T, Milán, M

“…The Drosophila wing primordium is subdivided into a dorsal (D) and a ventral (V) compartment by the activity of the LIM-homeodomain protein Apterous in D…”
Get full text

Robustness and stability of the gene regulatory network involved in DV boundary formation in the Drosophila wing by Buceta, Javier, Herranz, Héctor, Canela-Xandri, Oriol, Reigada, Ramon, Sagués, Francesc, Milán, Marco

“…Gene regulatory networks have been conserved during evolution. The Drosophila wing and the vertebrate hindbrain share the gene network involved in the…”
Get full text

Oncogenic cooperation between Yorkie and the conserved microRNA miR-8 in the wing disc of Drosophila by Sander, Moritz, Eichenlaub, Teresa, Herranz, Héctor

“…Tissue growth has to be carefully controlled to generate well-functioning organs. MicroRNAs are small non-coding RNAs that modulate the activity of target…”
Get full text

Yorkie and JNK Control Tumorigenesis in Drosophila Cells with Cytokinesis Failure by Gerlach, Stephan U., Eichenlaub, Teresa, Herranz, Héctor

“…Cytokinesis failure may result in the formation of polyploid cells, and subsequent mitosis can lead to aneuploidy and tumor formation. Tumor suppressor…”
Get full text

Genomic instability and cancer: lessons from Drosophila by Gerlach, Stephan U, Herranz, Héctor

“…Cancer is a genetic disease that involves the gradual accumulation of mutations. Human tumours are genetically unstable. However, the current knowledge about…”
Get full text

FOXO-regulated OSER1 reduces oxidative stress and extends lifespan in multiple species by Song, Jiangbo, Li, Zhiquan, Zhou, Lei, Chen, Xin, Sew, Wei Qi Guinevere, Herranz, Héctor, Ye, Zilu, Olsen, Jesper Velgaard, Li, Yuan, Nygaard, Marianne, Christensen, Kaare, Tong, Xiaoling, Bohr, Vilhelm A., Rasmussen, Lene Juel, Dai, Fangyin

“…FOXO transcription factors modulate aging-related pathways and influence longevity in multiple species, but the transcriptional targets that mediate these…”
Get full text

Mechanisms of oncogenic cell competition–Paths of victory by Gutiérrez-Martínez, Alejandro, Sew, Wei Qi Guinevere, Molano-Fernández, Maria, Carretero-Junquera, Maria, Herranz, Héctor

“…Cancer is a multistep process. In the early phases of this disease, mutations in oncogenes and tumor suppressors are thought to promote clonal expansion. These…”
Get full text

The functions of pannier during Drosophila embryogenesis by Herranz, H, Morata, G

“…The pannier ( pnr ) gene of Drosophila encodes a zinc-finger transcription factor of the GATA family and is involved in several developmental processes during…”
Get full text

Warburg Effect Metabolism Drives Neoplasia in a Drosophila Genetic Model of Epithelial Cancer by Eichenlaub, Teresa, Villadsen, René, Freitas, Flávia C.P., Andrejeva, Diana, Aldana, Blanca I., Nguyen, Hung Than, Petersen, Ole William, Gorodkin, Jan, Herranz, Héctor, Cohen, Stephen M.

“…Cancers develop in a complex mutational landscape. Genetic models of tumor formation have been used to explore how combinations of mutations cooperate to…”
Get full text

Generation of medial and lateral dorsal body domains by the pannier gene of Drosophila by Calleja, M, Herranz, H, Estella, C, Casal, J, Lawrence, P, Simpson, P, Morata, G

“…The pannier (pnr) gene encodes a GATA transcription factor and acts in several developmental processes in Drosophila, including embryonic dorsal closure,…”
Get full text

Crosstalk between Epithelial and Mesenchymal Tissues in Tumorigenesis and Imaginal Disc Development by Herranz, Héctor, Weng, Ruifen, Cohen, Stephen M.

“…Cancers develop in a complex mutational landscape. Interaction of genetically abnormal cancer cells with normal stromal cells can modify the local…”
Get full text

Mutual Repression by Bantam miRNA and Capicua Links the EGFR/MAPK and Hippo Pathways in Growth Control by Herranz, Héctor, Hong, Xin, Cohen, Stephen M.

“…The epidermal growth factor receptor (EGFR) and Hippo signaling pathways control cell proliferation and apoptosis to promote tissue growth during development…”
Get full text

The chromatin remodeling BAP complex limits tumor-promoting activity of the Hippo pathway effector Yki to prevent neoplastic transformation in Drosophila epithelia by Song, Shilin, Herranz, Héctor, Cohen, Stephen M

“…Switch/sucrose non-fermentable (SWI/SNF) chromatin remodeling complexes are mutated in many human cancers. In this article, we make use of a genetic model for…”
Get full text