Full‐Genome Sequence of Porcine Circovirus type 3 recovered from serum of sows with stillbirths in Brazil

Full‐Genome Sequence of Porcine Circovirus type 3 recovered from serum of sows with stillbirths in Brazil

Summary Two full‐genome sequences of porcine circovirus type 3 (PCV3) are reported. The genomes were recovered from pooled serum samples from sows who had just delivered litters with variable numbers of stillbirths. The two circular genomes (PCV3‐BR/RS/6 and PCV3‐BR/RS/8) are 2,000 nucleotides long...

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Published in:Transboundary and emerging diseases Vol. 65; no. 1; pp. 5 - 9
Main Authors: Tochetto, C., Lima, D. A., Varela, A. P. M., Loiko, M. R., Paim, W. P., Scheffer, C. M., Herpich, J. I., Cerva, C., Schmitd, C., Cibulski, S. P., Santos, A. C., Mayer, F. Q., Roehe, P. M.
Format: Journal Article
Language:English
Published: Germany Hindawi Limited 01-02-2018
Subjects:
circovirus
DNA helicase
Farms
Gene sequencing
Genomes
high‐throughput sequencing
Nucleotide sequence
Nucleotides
Open reading frames
Proteins
Replicase
reproductive failure
swine
Brazil
swine
reproductive failure
circovirus
high-throughput sequencing
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Summary:Summary Two full‐genome sequences of porcine circovirus type 3 (PCV3) are reported. The genomes were recovered from pooled serum samples from sows who had just delivered litters with variable numbers of stillbirths. The two circular genomes (PCV3‐BR/RS/6 and PCV3‐BR/RS/8) are 2,000 nucleotides long and contain two open reading frames (ORFs) oriented in opposite directions that encode the putative capsid (Cap) and replicase (Rep) proteins. The intergenic region contains a stem‐loop motif, as reported for other circoviruses. Rolling circle replication motifs and putative helicase domains were identified in the Rep coding region. The degree of overall nucleotide similarity between the genomes reported here and those available at GenBank was higher than 97%. No PCV3 sequence was detected in pooled serum samples from sows which had no stillbirths on the same farms. However, further studies are necessary to confirm the association between PCV3 and the occurrence of stillbirths.
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ISSN:1865-1674
1865-1682
DOI:10.1111/tbed.12735