Search Results - "Herold, Tobias"

Spectrum and prognostic relevance of driver gene mutations in acute myeloid leukemia by Metzeler, Klaus H., Herold, Tobias, Rothenberg-Thurley, Maja, Amler, Susanne, Sauerland, Maria C., Görlich, Dennis, Schneider, Stephanie, Konstandin, Nikola P., Dufour, Annika, Bräundl, Kathrin, Ksienzyk, Bianka, Zellmeier, Evelyn, Hartmann, Luise, Greif, Philipp A., Fiegl, Michael, Subklewe, Marion, Bohlander, Stefan K., Krug, Utz, Faldum, Andreas, Berdel, Wolfgang E., Wörmann, Bernhard, Büchner, Thomas, Hiddemann, Wolfgang, Braess, Jan, Spiekermann, Karsten

“…The clinical and prognostic relevance of many recently identified driver gene mutations in adult acute myeloid leukemia (AML) is poorly defined. We sequenced…”
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Does combining numerous data types in multi-omics data improve or hinder performance in survival prediction? Insights from a large-scale benchmark study by Li, Yingxia, Herold, Tobias, Mansmann, Ulrich, Hornung, Roman

“…Predictive modeling based on multi-omics data, which incorporates several types of omics data for the same patients, has shown potential to outperform…”
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Validation and refinement of the revised 2017 European LeukemiaNet genetic risk stratification of acute myeloid leukemia by Herold, Tobias, Rothenberg-Thurley, Maja, Grunwald, Victoria V., Janke, Hanna, Goerlich, Dennis, Sauerland, Maria C., Konstandin, Nikola P., Dufour, Annika, Schneider, Stephanie, Neusser, Michaela, Ksienzyk, Bianka, Greif, Philipp A., Subklewe, Marion, Faldum, Andreas, Bohlander, Stefan K., Braess, Jan, Wörmann, Bernhard, Krug, Utz, Berdel, Wolfgang E., Hiddemann, Wolfgang, Spiekermann, Karsten, Metzeler, Klaus H.

“…The revised 2017 European LeukemiaNet (ELN) recommendations for genetic risk stratification of acute myeloid leukemia have been widely adopted, but have not…”
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Priority-Lasso: a simple hierarchical approach to the prediction of clinical outcome using multi-omics data by Klau, Simon, Jurinovic, Vindi, Hornung, Roman, Herold, Tobias, Boulesteix, Anne-Laure

“…The inclusion of high-dimensional omics data in prediction models has become a well-studied topic in the last decades. Although most of these methods do not…”
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Persistence of pre-leukemic clones during first remission and risk of relapse in acute myeloid leukemia by Rothenberg-Thurley, Maja, Amler, Susanne, Goerlich, Dennis, Köhnke, Thomas, Konstandin, Nikola P., Schneider, Stephanie, Sauerland, Maria C., Herold, Tobias, Hubmann, Max, Ksienzyk, Bianka, Zellmeier, Evelyn, Bohlander, Stefan K., Subklewe, Marion, Faldum, Andreas, Hiddemann, Wolfgang, Braess, Jan, Spiekermann, Karsten, Metzeler, Klaus H.

“…Some patients with acute myeloid leukemia (AML) who are in complete remission after induction chemotherapy harbor persisting pre-leukemic clones, carrying a…”
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Genetics of acute myeloid leukemia in the elderly: mutation spectrum and clinical impact in intensively treated patients aged 75 years or older by Prassek, Victoria V, Rothenberg-Thurley, Maja, Sauerland, Maria C, Herold, Tobias, Janke, Hanna, Ksienzyk, Bianka, Konstandin, Nikola P, Goerlich, Dennis, Krug, Utz, Faldum, Andreas, Berdel, Wolfgang E, Wörmann, Bernhard, Braess, Jan, Schneider, Stephanie, Subklewe, Marion, Bohlander, Stefan K, Hiddemann, Wolfgang, Spiekermann, Karsten, Metzeler, Klaus H

“…A cute myeloid leukemia is a disease of the elderly (median age at diagnosis, 65-70 years). The prognosis of older acute myeloid leukemia patients is generally…”
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Adults with Philadelphia chromosome-like acute lymphoblastic leukemia frequently have IGH-CRLF2 and JAK2 mutations, persistence of minimal residual disease and poor prognosis by Herold, Tobias, Schneider, Stephanie, Metzeler, Klaus H, Neumann, Martin, Hartmann, Luise, Roberts, Kathryn G, Konstandin, Nikola P, Greif, Philipp A, Bräundl, Kathrin, Ksienzyk, Bianka, Huk, Natalia, Schneider, Irene, Zellmeier, Evelyn, Jurinovic, Vindi, Mansmann, Ulrich, Hiddemann, Wolfgang, Mullighan, Charles G, Bohlander, Stefan K, Spiekermann, Karsten, Hoelzer, Dieter, Brüggemann, Monika, Baldus, Claudia D, Dreyling, Martin, Gökbuget, Nicola

“…Philadelphia-like B-cell precursor acute lymphoblastic leukemia (Ph-like ALL) is characterized by distinct genetic alterations and inferior prognosis in…”
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miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia by Jiang, Xi, Hu, Chao, Arnovitz, Stephen, Bugno, Jason, Yu, Miao, Zuo, Zhixiang, Chen, Ping, Huang, Hao, Ulrich, Bryan, Gurbuxani, Sandeep, Weng, Hengyou, Strong, Jennifer, Wang, Yungui, Li, Yuanyuan, Salat, Justin, Li, Shenglai, Elkahloun, Abdel G., Yang, Yang, Neilly, Mary Beth, Larson, Richard A., Le Beau, Michelle M., Herold, Tobias, Bohlander, Stefan K., Liu, Paul P., Zhang, Jiwang, Li, Zejuan, He, Chuan, Jin, Jie, Hong, Seungpyo, Chen, Jianjun

“…MicroRNAs are subject to precise regulation and have key roles in tumorigenesis. In contrast to the oncogenic role of miR-22 reported in myelodysplastic…”
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A 29-gene and cytogenetic score for the prediction of resistance to induction treatment in acute myeloid leukemia by Herold, Tobias, Jurinovic, Vindi, Batcha, Aarif M N, Bamopoulos, Stefanos A, Rothenberg-Thurley, Maja, Ksienzyk, Bianka, Hartmann, Luise, Greif, Philipp A, Phillippou-Massier, Julia, Krebs, Stefan, Blum, Helmut, Amler, Susanne, Schneider, Stephanie, Konstandin, Nikola, Sauerland, Maria Cristina, Görlich, Dennis, Berdel, Wolfgang E, Wörmann, Bernhard J, Tischer, Johanna, Subklewe, Marion, Bohlander, Stefan K, Braess, Jan, Hiddemann, Wolfgang, Metzeler, Klaus H, Mansmann, Ulrich, Spiekermann, Karsten

“…Primary therapy resistance is a major problem in acute myeloid leukemia treatment. We set out to develop a powerful and robust predictor for therapy resistance…”
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Fusion gene detection by RNA-sequencing complements diagnostics of acute myeloid leukemia and identifies recurring NRIP1-MIR99AHG rearrangements by Kerbs, Paul, Vosberg, Sebastian, Krebs, Stefan, Graf, Alexander, Blum, Helmut, Swoboda, Anja, Batcha, Aarif M N, Mansmann, Ulrich, Metzler, Dirk, Heckman, Caroline A, Herold, Tobias, Greif, Philipp A

“…Identification of fusion genes in clinical routine is mostly based on cytogenetics and targeted molecular genetics, such as metaphase karyotyping, fluorescence…”
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Dynamics of SARS-CoV-2 shedding in the respiratory tract depends on the severity of disease in COVID-19 patients by Munker, Dieter, Osterman, Andreas, Stubbe, Hans, Muenchhoff, Maximilian, Veit, Tobias, Weinberger, Tobias, Barnikel, Michaela, Mumm, Jan-Niclas, Milger, Katrin, Khatamzas, Elham, Klauss, Sarah, Scherer, Clemens, Hellmuth, Johannes C, Giessen-Jung, Clemens, Zoller, Michael, Herold, Tobias, Stecher, Stephanie, de Toni, Enrico N, Schulz, Christian, Kneidinger, Nikolaus, Keppler, Oliver T, Behr, Jürgen, Mayerle, Julia, Munker, Stefan

“…A fraction of COVID-19 patients progress to a severe disease manifestation with respiratory failure and the necessity of mechanical ventilation. Identifying…”
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Clinical and preclinical characterization of CD99 isoforms in acute myeloid leukemia by Vaikari, Vijaya Pooja, Du, Yang, Wu, Sharon, Zhang, Tian, Metzeler, Klaus, Batcha, Aarif M N, Herold, Tobias, Hiddemann, Wolfgang, Akhtari, Mojtaba, Alachkar, Houda

“…In an effort to identify target genes in acute myeloid leukemia (AML), we compared gene expression profiles between normal and AML cells from various publicly…”
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Combined proteomics and CRISPR‒Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo by Bahrami, Ehsan, Schmid, Jan Philipp, Jurinovic, Vindi, Becker, Martin, Wirth, Anna-Katharina, Ludwig, Romina, Kreissig, Sophie, Duque Angel, Tania Vanessa, Amend, Diana, Hunt, Katharina, Öllinger, Rupert, Rad, Roland, Frenz, Joris Maximilian, Solovey, Maria, Ziemann, Frank, Mann, Matthias, Vick, Binje, Wichmann, Christian, Herold, Tobias, Jayavelu, Ashok Kumar, Jeremias, Irmela

“…Acute leukemias represent deadly malignancies that require better treatment. As a challenge, treatment is counteracted by a microenvironment protecting dormant…”
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The retinoic acid receptor co-factor NRIP1 is uniquely upregulated and represents a therapeutic target in acute myeloid leukemia with chromosome 3q rearrangements by Grasedieck, Sarah, Cabantog, Ariene, MacPhee, Liam, Im, Junbum, Ruess, Christoph, Demir, Burcu, Sperb, Nadine, Rücker, Frank G., Döhner, Konstanze, Herold, Tobias, Pollack, Jonathan R., Bullinger, Lars, Rouhi, Arefeh, Kuchenbauer, Florian

“…Aberrant expression of Ecotropic Viral Integration Site 1 (EVI1) is a hallmark of acute myeloid leukemia (AML) with inv(3) or t(3;3), which is a disease…”
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Dual checkpoint blockade of CD47 and LILRB1 enhances CD20 antibody-dependent phagocytosis of lymphoma cells by macrophages by Zeller, Tobias, Lutz, Sebastian, Münnich, Ira A., Windisch, Roland, Hilger, Patricia, Herold, Tobias, Tahiri, Natyra, Banck, Jan C., Weigert, Oliver, Moosmann, Andreas, von Bergwelt-Baildon, Michael, Flamann, Cindy, Bruns, Heiko, Wichmann, Christian, Baumann, Niklas, Valerius, Thomas, Schewe, Denis M., Peipp, Matthias, Rösner, Thies, Humpe, Andreas, Kellner, Christian

“…Antibody-dependent cellular phagocytosis (ADCP) by macrophages, an important effector function of tumor targeting antibodies, is hampered by ‘Don´t Eat Me!’…”
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Activating FLT3 mutants show distinct gain-of-function phenotypes in vitro and a characteristic signaling pathway profile associated with prognosis in acute myeloid leukemia by Janke, Hanna, Pastore, Friederike, Schumacher, Daniela, Herold, Tobias, Hopfner, Karl-Peter, Schneider, Stephanie, Berdel, Wolfgang E, Büchner, Thomas, Woermann, Bernhard J, Subklewe, Marion, Bohlander, Stefan K, Hiddemann, Wolfgang, Spiekermann, Karsten, Polzer, Harald

“…About 30% of patients with acute myeloid leukemia (AML) harbour mutations of the receptor tyrosine kinase FLT3, mostly internal tandem duplications (ITD) and…”
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Plasticity in growth behavior of patients' acute myeloid leukemia stem cells growing in mice by Ebinger, Sarah, Zeller, Christina, Carlet, Michela, Senft, Daniela, Bagnoli, Johannes W, Liu, Wen-Hsin, Rothenberg-Thurley, Maja, Enard, Wolfgang, Metzeler, Klaus H, Herold, Tobias, Spiekermann, Karsten, Vick, Binje, Jeremias, Irmela

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Loss-of-function mutations in the histone methyltransferase EZH2 promote chemotherapy resistance in AML by Kempf, Julia M., Weser, Sabrina, Bartoschek, Michael D., Metzeler, Klaus H., Vick, Binje, Herold, Tobias, Völse, Kerstin, Mattes, Raphael, Scholz, Manuela, Wange, Lucas E., Festini, Moreno, Ugur, Enes, Roas, Maike, Weigert, Oliver, Bultmann, Sebastian, Leonhardt, Heinrich, Schotta, Gunnar, Hiddemann, Wolfgang, Jeremias, Irmela, Spiekermann, Karsten

“…Chemotherapy resistance is the main impediment in the treatment of acute myeloid leukaemia (AML). Despite rapid advances, the various mechanisms inducing…”
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Ph-like Acute Lymphoblastic Leukemia in Older Adults by Herold, Tobias, Baldus, Claudia D., Gökbuget, Nicola

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In vivo inducible reverse genetics in patients’ tumors to identify individual therapeutic targets by Carlet, Michela, Völse, Kerstin, Vergalli, Jenny, Becker, Martin, Herold, Tobias, Arner, Anja, Senft, Daniela, Jurinovic, Vindi, Liu, Wen-Hsin, Gao, Yuqiao, Dill, Veronika, Fehse, Boris, Baldus, Claudia D., Bastian, Lorenz, Lenk, Lennart, Schewe, Denis M., Bagnoli, Johannes W., Vick, Binje, Schmid, Jan Philipp, Wilhelm, Alexander, Marschalek, Rolf, Jost, Philipp J., Miething, Cornelius, Riecken, Kristoffer, Schmidt-Supprian, Marc, Binder, Vera, Jeremias, Irmela

“…High-throughput sequencing describes multiple alterations in individual tumors, but their functional relevance is often unclear. Clinic-close, individualized…”
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