Search Results - "Herold, Marco J."

Emerging connectivity of programmed cell death pathways and its physiological implications by Bedoui, Sammy, Herold, Marco J., Strasser, Andreas

“…The removal of functionally dispensable, infected or potentially neoplastic cells is driven by programmed cell death (PCD) pathways, highlighting their…”
Get full text

Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production by White, Michael J., McArthur, Kate, Metcalf, Donald, Lane, Rachael M., Cambier, John C., Herold, Marco J., van Delft, Mark F., Bedoui, Sammy, Lessene, Guillaume, Ritchie, Matthew E., Huang, David C.S., Kile, Benjamin T.

“…Activated caspases are a hallmark of apoptosis induced by the intrinsic pathway, but they are dispensable for cell death and the apoptotic clearance of cells…”
Get full text

An Inducible Lentiviral Guide RNA Platform Enables the Identification of Tumor-Essential Genes and Tumor-Promoting Mutations In Vivo by Aubrey, Brandon J., Kelly, Gemma L., Kueh, Andrew J., Brennan, Margs S., O’Connor, Liam, Milla, Liz, Wilcox, Stephen, Tai, Lin, Strasser, Andreas, Herold, Marco J.

“…The CRISPR/Cas9 technology enables the introduction of genomic alterations into almost any organism; however, systems for efficient and inducible gene…”
Get full text

Modeling Breast Cancer Using CRISPR-Cas9–Mediated Engineering of Human Breast Organoids by Dekkers, Johanna F, Whittle, James R, Vaillant, François, Chen, Huei-Rong, Dawson, Caleb, Liu, Kevin, Geurts, Maarten H, Herold, Marco J, Clevers, Hans, Lindeman, Geoffrey J, Visvader, Jane E

“…Abstract Breast cancer is characterized by histological and functional heterogeneity, posing a clinical challenge for patient treatment. Emerging evidence…”
Get full text

NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase‐4 and caspase‐5 by Baker, Paul J., Boucher, Dave, Bierschenk, Damien, Tebartz, Christina, Whitney, Paul G., D'Silva, Damian B., Tanzer, Maria C., Monteleone, Mercedes, Robertson, Avril A. B., Cooper, Matthew A., Alvarez‐Diaz, Silvia, Herold, Marco J., Bedoui, Sammy, Schroder, Kate, Masters, Seth L.

“…Humans encode two inflammatory caspases that detect cytoplasmic LPS, caspase‐4 and caspase‐5. When activated, these trigger pyroptotic cell death and…”
Get full text

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection by Doerflinger, Marcel, Deng, Yexuan, Whitney, Paul, Salvamoser, Ranja, Engel, Sven, Kueh, Andrew J., Tai, Lin, Bachem, Annabell, Gressier, Elise, Geoghegan, Niall D., Wilcox, Stephen, Rogers, Kelly L., Garnham, Alexandra L., Dengler, Michael A., Bader, Stefanie M., Ebert, Gregor, Pearson, Jaclyn S., De Nardo, Dominic, Wang, Nancy, Yang, Chenying, Pereira, Milton, Bryant, Clare E., Strugnell, Richard A., Vince, James E., Pellegrini, Marc, Strasser, Andreas, Bedoui, Sammy, Herold, Marco J.

“…Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necroptosis, and apoptosis during…”
Get full text

Macrophage and neutrophil death programs differentially confer resistance to tuberculosis by Stutz, Michael Dominic, Allison, Cody Charles, Ojaimi, Samar, Preston, Simon Peter, Doerflinger, Marcel, Arandjelovic, Philip, Whitehead, Lachlan, Bader, Stefanie M., Batey, Daniel, Asselin-Labat, Marie-Liesse, Herold, Marco J., Strasser, Andreas, West, Nicholas P., Pellegrini, Marc

“…Apoptosis can potently defend against intracellular pathogens by directly killing microbes and eliminating their replicative niche. However, the reported…”
Get full text

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia by Glaser, Stefan P, Lee, Erinna F, Trounson, Evelyn, Bouillet, Philippe, Wei, Andrew, Fairlie, W Douglas, Izon, David J, Zuber, Johannes, Rappaport, Amy R, Herold, Marco J, Alexander, Warren S, Lowe, Scott W, Robb, Lorraine, Strasser, Andreas

“…Acute myeloid leukemia (AML) frequently relapses after initial treatment. Drug resistance in AML has been attributed to high levels of the anti-apoptotic Bcl-2…”
Get full text

The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation by Vijayaraj, Swarna L., Feltham, Rebecca, Rashidi, Maryam, Frank, Daniel, Liu, Zhengyang, Simpson, Daniel S., Ebert, Gregor, Vince, Angelina, Herold, Marco J., Kueh, Andrew, Pearson, Jaclyn S., Dagley, Laura F., Murphy, James M., Webb, Andrew I., Lawlor, Kate E., Vince, James E.

“…Interleukin-1β (IL-1β) is activated by inflammasome-associated caspase-1 in rare autoinflammatory conditions and in a variety of other inflammatory diseases…”
Get full text

VDAC2 enables BAX to mediate apoptosis and limit tumor development by Chin, Hui San, Li, Mark X., Tan, Iris K. L., Ninnis, Robert L., Reljic, Boris, Scicluna, Kristen, Dagley, Laura F., Sandow, Jarrod J., Kelly, Gemma L., Samson, Andre L., Chappaz, Stephane, Khaw, Seong L., Chang, Catherine, Morokoff, Andrew, Brinkmann, Kerstin, Webb, Andrew, Hockings, Colin, Hall, Cathrine M., Kueh, Andrew J., Ryan, Michael T., Kluck, Ruth M., Bouillet, Philippe, Herold, Marco J., Gray, Daniel H. D., Huang, David C. S., van Delft, Mark F., Dewson, Grant

“…Intrinsic apoptosis is critical to prevent tumor formation and is engaged by many anti-cancer agents to eliminate tumor cells. BAX and BAK, the two essential…”
Get full text

MARCH1-mediated ubiquitination of MHC II impacts the MHC I antigen presentation pathway by Wilson, Kayla R, Liu, Haiyin, Healey, Geraldine, Vuong, Vivian, Ishido, Satoshi, Herold, Marco J, Villadangos, Jose A, Mintern, Justine D

“…Major histocompatibility complex class II (MHC II) expression and turn-over are regulated via its ubiquitination by the membrane associated RING-CH 1 (MARCH1)…”
Get full text

Single-Cell Transcriptomics Identifies the Adaptation of Scart1+ Vγ6+ T Cells to Skin Residency as Activated Effector Cells by Tan, Likai, Sandrock, Inga, Odak, Ivan, Aizenbud, Yuval, Wilharm, Anneke, Barros-Martins, Joana, Tabib, Yaara, Borchers, Alina, Amado, Tiago, Gangoda, Lahiru, Herold, Marco J., Schmidt-Supprian, Marc, Kisielow, Jan, Silva-Santos, Bruno, Koenecke, Christian, Hovav, Avi-Hai, Krebs, Christian, Prinz, Immo, Ravens, Sarina

“…IL-17-producing γδ T cells express oligoclonal Vγ4+ and Vγ6+ TCRs, mainly develop in the prenatal thymus, and later persist as long-lived self-renewing cells…”
Get full text

The BH3-Only Proteins Bim and Puma Cooperate to Impose Deletional Tolerance of Organ-Specific Antigens by Gray, Daniel H.D., Kupresanin, Fiona, Berzins, Stuart P., Herold, Marco J., O'Reilly, Lorraine A., Bouillet, Philippe, Strasser, Andreas

“…Although the proapoptotic BH3-only protein, Bim, is required for deletion of autoreactive thymocytes, Bim-deficient mice do not succumb to extensive…”
Get full text

Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT by Chopin, Michaël, Lun, Aaron T., Zhan, Yifan, Schreuder, Jaring, Coughlan, Hannah, D’Amico, Angela, Mielke, Lisa A., Almeida, Francisca F., Kueh, Andrew J., Dickins, Ross A., Belz, Gabrielle T., Naik, Shalin H., Lew, Andrew M., Bouillet, Phillipe, Herold, Marco J., Smyth, Gordon K., Corcoran, Lynn M., Nutt, Stephen L.

“…Dendritic cells (DCs) are can be broadly divided into conventional (cDC) and plasmacytoid (pDC) subsets. Despite the importance of this lineage diversity, its…”
Get full text

PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling by Yao, Bing, Gui, Tao, Zeng, Xiangwei, Deng, Yexuan, Wang, Zhi, Wang, Ying, Yang, Dongjun, Li, Qixiang, Xu, Peipei, Hu, Ruifeng, Li, Xinyu, Chen, Bing, Wang, Jin, Zen, Ke, Li, Haitao, Davis, Melissa J, Herold, Marco J, Pan, Hua-Feng, Jiang, Zhi-Wei, Huang, David C S, Liu, Ming, Ju, Junyi, Zhao, Quan

“…Aberrant changes in epigenetic mechanisms such as histone modifications play an important role in cancer progression. PRMT1 which triggers asymmetric…”
Get full text

DR5 and caspase-8 are dispensable in ER stress-induced apoptosis by Glab, Jason A, Doerflinger, Marcel, Nedeva, Christina, Jose, Irvin, Mbogo, George W, Paton, James C, Paton, Adrienne W, Kueh, Andrew J, Herold, Marco J, Huang, David CS, Segal, David, Brumatti, Gabriella, Puthalakath, Hamsa

“…The endoplasmic reticulum (ER) stress response constitutes cellular reactions triggered by a wide variety of stimuli that disturb folding of proteins, often…”
Get full text

Deletion of Gpatch2 does not alter Tnf expression in mice by Dalseno, Destiny, Anderton, Holly, Kueh, Andrew, Herold, Marco J, Silke, John, Strasser, Andreas, Bouillet, Philippe

“…The cytokine TNF has essential roles in immune defence against diverse pathogens and, when its expression is deregulated, it can drive severe inflammatory…”
Get full text

Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance by Deng, Yexuan, Diepstraten, Sarah T., Potts, Margaret A., Giner, Göknur, Trezise, Stephanie, Ng, Ashley P., Healey, Gerry, Kane, Serena R., Cooray, Amali, Behrens, Kira, Heidersbach, Amy, Kueh, Andrew J., Pal, Martin, Wilcox, Stephen, Tai, Lin, Alexander, Warren S., Visvader, Jane E., Nutt, Stephen L., Strasser, Andreas, Haley, Benjamin, Zhao, Quan, Kelly, Gemma L., Herold, Marco J.

“…CRISPR technologies have advanced cancer modelling in mice, but CRISPR activation (CRISPRa) methods have not been exploited in this context. We establish a…”
Get full text

Deletion of the transcriptional regulator TFAP4 accelerates c-MYC-driven lymphomagenesis by Potts, Margaret A., Mizutani, Shinsuke, Garnham, Alexandra L., Li Wai Suen, Connie S. N., Kueh, Andrew J., Tai, Lin, Pal, Martin, Strasser, Andreas, Herold, Marco J.

“…Many lymphoid malignancies arise from deregulated c-MYC expression in cooperation with additional genetic lesions. While many of these cooperative genetic…”
Get full text

FHL1 promotes chikungunya and o’nyong-nyong virus infection and pathogenesis with implications for alphavirus vaccine design by Ng, Wern Hann, Liu, Xiang, Ling, Zheng L., Santos, Camilla N. O., Magalhães, Lucas S., Kueh, Andrew J., Herold, Marco J., Taylor, Adam, Freitas, Joseph R., Koit, Sandra, Wang, Sainan, Lloyd, Andrew R., Teixeira, Mauro M., Merits, Andres, Almeida, Roque P., King, Nicholas J. C., Mahalingam, Suresh

“…Arthritogenic alphaviruses are positive-strand RNA viruses that cause debilitating musculoskeletal diseases affecting millions worldwide. A recent discovery…”
Get full text