Search Results - "Herok, Marcin"

Therapy-Induced Senescent/Polyploid Cancer Cells Undergo Atypical Divisions Associated with Altered Expression of Meiosis, Spermatogenesis and EMT Genes by Czarnecka-Herok, Joanna, Sliwinska, Malgorzata Alicja, Herok, Marcin, Targonska, Alicja, Strzeszewska-Potyrala, Anna, Bojko, Agnieszka, Wolny, Artur, Mosieniak, Grazyna, Sikora, Ewa

“…Upon anticancer treatment, cancer cells can undergo cellular senescence, i.e., the temporal arrest of cell division, accompanied by polyploidization and…”
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Small-Molecule Inhibitors of the m7G-RNA Writer METTL1 by Nai, Francesco, Flores Espinoza, Maria Paula, Invernizzi, Annalisa, Vargas-Rosales, Pablo Andrés, Bobileva, Olga, Herok, Marcin, Caflisch, Amedeo

“…We discovered the first inhibitors of the m7G-RNA writer METTL1 by high-throughput docking and an enzymatic assay based on luminescence. Eleven compounds,…”
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Chromatin-Directed Proteomics Identifies ZNF84 as a p53-Independent Regulator of p21 in Genotoxic Stress Response by Strzeszewska-Potyrała, Anna, Staniak, Karolina, Czarnecka-Herok, Joanna, Rafiee, Mahmoud-Reza, Herok, Marcin, Mosieniak, Grażyna, Krijgsveld, Jeroen, Sikora, Ewa

“…The p21 protein, encoded by , plays a vital role in senescence, and its transcriptional control by the tumour suppressor p53 is well-established. However, p21…”
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Proteolysis Targeting Chimera Degraders of the METTL3–14 m6A‑RNA Methyltransferase by Errani, Francesco, Invernizzi, Annalisa, Herok, Marcin, Bochenkova, Elena, Stamm, Fiona, Corbeski, Ivan, Romanucci, Valeria, Di Fabio, Giovanni, Zálešák, František, Caflisch, Amedeo

“…Methylation of adenine N6 (m6A) is the most frequent RNA modification. On mRNA, it is catalyzed by the METTL3–14 heterodimer complex, which plays a key role in…”
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Structure-Based Design of a Potent and Selective YTHDC1 Ligand by Zálešák, František, Nai, Francesco, Herok, Marcin, Bochenkova, Elena, Bedi, Rajiv K., Li, Yaozong, Errani, Francesco, Caflisch, Amedeo

“…N6-Adenosine methylation (m6A) is a prevalent post-transcriptional modification of mRNA, with YTHDC1 being the reader protein responsible for recognizing this…”
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Chemotherapy of HER2- and MDM2-Enriched Breast Cancer Subtypes Induces Homologous Recombination DNA Repair and Chemoresistance by Herok, Marcin, Wawrzynow, Bartosz, Maluszek, Marta J., Olszewski, Maciej B., Zylicz, Alicja, Zylicz, Maciej

“…Analyzing the TCGA breast cancer database, we discovered that patients with the HER2 cancer subtype and overexpression of MDM2 exhibited decreased…”
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Molecular chaperones in the acquisition of cancer cell chemoresistance with mutated TP53 and MDM2 up-regulation by Tracz-Gaszewska, Zuzanna, Klimczak, Marta, Biecek, Przemyslaw, Herok, Marcin, Kosinski, Marcin, Olszewski, Maciej B, Czerwińska, Patrycja, Wiech, Milena, Wiznerowicz, Maciej, Zylicz, Alicja, Zylicz, Maciej, Wawrzynow, Bartosz

“…Utilizing the TCGA PANCAN12 dataset we discovered that cancer patients with mutations in tumor suppressor and overexpression of oncogene exhibited decreased…”
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Proteolysis Targeting Chimera Degraders of the METTL3-14 m 6 A-RNA Methyltransferase by Errani, Francesco, Invernizzi, Annalisa, Herok, Marcin, Bochenkova, Elena, Stamm, Fiona, Corbeski, Ivan, Romanucci, Valeria, Di Fabio, Giovanni, Zálešák, František, Caflisch, Amedeo

“…Methylation of adenine N6 (m A) is the most frequent RNA modification. On mRNA, it is catalyzed by the METTL3-14 heterodimer complex, which plays a key role in…”
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Novel role for the testis‐enriched HSPA2 protein in regulating epidermal keratinocyte differentiation by Gogler‐Pigłowska, Agnieszka, Klarzyńska, Katarzyna, Sojka, Damian R., Habryka, Anna, Głowala‐Kosińska, Magdalena, Herok, Marcin, Kryj, Mariusz, Halczok, Monika, Krawczyk, Zdzisław, Scieglinska, Dorota

“…HSPA2, a poorly characterized member of the HSPA (HSP70) chaperone family, is a testis‐enriched protein involved in male germ cell differentiation. Previously,…”
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