Search Results - "Hernando‐Momblona, Xavier"

Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+ Intestinal Stem Cells by Barriga, Francisco M., Montagni, Elisa, Mana, Miyeko, Mendez-Lago, Maria, Hernando-Momblona, Xavier, Sevillano, Marta, Guillaumet-Adkins, Amy, Rodriguez-Esteban, Gustavo, Buczacki, Simon J.A., Gut, Marta, Heyn, Holger, Winton, Douglas J., Yilmaz, Omer H., Attolini, Camille Stephan-Otto, Gut, Ivo, Batlle, Eduard

“…Highly proliferative Lgr5+ stem cells maintain the intestinal epithelium and are thought to be largely homogeneous. Although quiescent intestinal stem cell…”
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A genome editing approach to study cancer stem cells in human tumors by Cortina, Carme, Turon, Gemma, Stork, Diana, Hernando‐Momblona, Xavier, Sevillano, Marta, Aguilera, Mònica, Tosi, Sébastien, Merlos‐Suárez, Anna, Stephan‐Otto Attolini, Camille, Sancho, Elena, Batlle, Eduard

“…The analysis of stem cell hierarchies in human cancers has been hampered by the impossibility of identifying or tracking tumor cell populations in an intact…”
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Modeling Biochemical Gradients In Vitro to Control Cell Compartmentalization in a Microengineered 3D Model of the Intestinal Epithelium by Altay, Gizem, Abad‐Lázaro, Aina, Gualda, Emilio J., Folch, Jordi, Insa, Claudia, Tosi, Sébastien, Hernando‐Momblona, Xavier, Batlle, Eduard, Loza‐Álvarez, Pablo, Fernández‐Majada, Vanesa, Martinez, Elena

“…Gradients of signaling pathways within the intestinal stem cell (ISC) niche are instrumental for cellular compartmentalization and tissue function, yet how are…”
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TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis by Tauriello, Daniele V. F., Palomo-Ponce, Sergio, Stork, Diana, Berenguer-Llergo, Antonio, Badia-Ramentol, Jordi, Iglesias, Mar, Sevillano, Marta, Ibiza, Sales, Cañellas, Adrià, Hernando-Momblona, Xavier, Byrom, Daniel, Matarin, Joan A., Calon, Alexandre, Rivas, Elisa I., Nebreda, Angel R., Riera, Antoni, Attolini, Camille Stephan-Otto, Batlle, Eduard

“…A combination of TGFβ inhibition and checkpoint-inhibition therapy provokes a potent cytotoxic response against metastatic tumours derived from colorectal…”
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Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer by Morral, Clara, Stanisavljevic, Jelena, Hernando-Momblona, Xavier, Mereu, Elisabetta, Álvarez-Varela, Adrián, Cortina, Carme, Stork, Diana, Slebe, Felipe, Turon, Gemma, Whissell, Gavin, Sevillano, Marta, Merlos-Suárez, Anna, Casanova-Martí, Àngela, Moutinho, Catia, Lowe, Scott W., Dow, Lukas E., Villanueva, Alberto, Sancho, Elena, Heyn, Holger, Batlle, Eduard

“…Colorectal cancers (CRCs) are composed of an amalgam of cells with distinct genotypes and phenotypes. Here, we reveal a previously unappreciated heterogeneity…”
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Long-term platinum-based drug accumulation in cancer-associated fibroblasts promotes colorectal cancer progression and resistance to therapy by Linares, Jenniffer, Sallent-Aragay, Anna, Badia-Ramentol, Jordi, Recort-Bascuas, Alba, Méndez, Ana, Manero-Rupérez, Noemí, Re, Daniele Lo, Rivas, Elisa I., Guiu, Marc, Zwick, Melissa, Iglesias, Mar, Martinez-Ciarpaglini, Carolina, Tarazona, Noelia, Varese, Monica, Hernando-Momblona, Xavier, Cañellas-Socias, Adrià, Orrillo, Mayra, Garrido, Marta, Saoudi, Nadia, Elez, Elena, Navarro, Pilar, Tabernero, Josep, Gomis, Roger R., Batlle, Eduard, Pisonero, Jorge, Cervantes, Andres, Montagut, Clara, Calon, Alexandre

“…A substantial proportion of cancer patients do not benefit from platinum-based chemotherapy (CT) due to the emergence of drug resistance. Here, we apply…”
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The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression by Whissell, Gavin, Montagni, Elisa, Martinelli, Paola, Hernando-Momblona, Xavier, Sevillano, Marta, Jung, Peter, Cortina, Carme, Calon, Alexandre, Abuli, Anna, Castells, Antoni, Castellvi-Bel, Sergi, Nacht, Ana Silvina, Sancho, Elena, Stephan-Otto Attolini, Camille, Vicent, Guillermo P., Real, Francisco X., Batlle, Eduard

“…Aberrant activation of WNT signalling and loss of BMP signals represent the two main alterations leading to the initiation of colorectal cancer (CRC). Here we…”
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FixNCut: single-cell genomics through reversible tissue fixation and dissociation by Jiménez-Gracia, Laura, Marchese, Domenica, Nieto, Juan C, Caratù, Ginevra, Melón-Ardanaz, Elisa, Gudiño, Victoria, Roth, Sara, Wise, Kellie, Ryan, Natalie K, Jensen, Kirk B, Hernando-Momblona, Xavier, Bernardes, Joana P, Tran, Florian, Sievers, Laura Katharina, Schreiber, Stefan, van den Berge, Maarten, Kole, Tessa, van der Velde, Petra L, Nawijn, Martijn C, Rosenstiel, Philip, Batlle, Eduard, Butler, Lisa M, Parish, Ian A, Plummer, Jasmine, Gut, Ivo, Salas, Azucena, Heyn, Holger, Martelotto, Luciano G

“…The use of single-cell technologies for clinical applications requires disconnecting sampling from downstream processing steps. Early sample preservation can…”
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Isolation of Human Colon Stem Cells Using Surface Expression of PTK7 by Jung, Peter, Sommer, Christian, Barriga, Francisco M., Buczacki, Simon J., Hernando-Momblona, Xavier, Sevillano, Marta, Duran-Frigola, Miquel, Aloy, Patrick, Selbach, Matthias, Winton, Douglas J., Batlle, Eduard

“…Insertion of reporter cassettes into the Lgr5 locus has enabled the characterization of mouse intestinal stem cells (ISCs). However, low cell surface abundance…”
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Stromal gene expression defines poor-prognosis subtypes in colorectal cancer by Calon, Alexandre, Lonardo, Enza, Berenguer-Llergo, Antonio, Espinet, Elisa, Hernando-Momblona, Xavier, Iglesias, Mar, Sevillano, Marta, Palomo-Ponce, Sergio, Tauriello, Daniele V F, Byrom, Daniel, Cortina, Carme, Morral, Clara, Barceló, Carles, Tosi, Sebastien, Riera, Antoni, Attolini, Camille Stephan-Otto, Rossell, David, Sancho, Elena, Batlle, Eduard

“…Eduard Batlle and colleagues find that poor-outcome subgroups of colorectal cancer are driven by genes expressed in tumor-associated stromal cells. They show…”
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Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells by Cañellas-Socias, Adrià, Cortina, Carme, Hernando-Momblona, Xavier, Palomo-Ponce, Sergio, Mulholland, Eoghan J., Turon, Gemma, Mateo, Lidia, Conti, Sefora, Roman, Olga, Sevillano, Marta, Slebe, Felipe, Stork, Diana, Caballé-Mestres, Adrià, Berenguer-Llergo, Antonio, Álvarez-Varela, Adrián, Fenderico, Nicola, Novellasdemunt, Laura, Jiménez-Gracia, Laura, Sipka, Tamara, Bardia, Lidia, Lorden, Patricia, Colombelli, Julien, Heyn, Holger, Trepat, Xavier, Tejpar, Sabine, Sancho, Elena, Tauriello, Daniele V. F., Leedham, Simon, Attolini, Camille Stephan-Otto, Batlle, Eduard

“…Around 30–40% of patients with colorectal cancer (CRC) undergoing curative resection of the primary tumour will develop metastases in the subsequent years 1 …”
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The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse by Merlos-Suárez, Anna, Barriga, Francisco M., Jung, Peter, Iglesias, Mar, Céspedes, María Virtudes, Rossell, David, Sevillano, Marta, Hernando-Momblona, Xavier, da Silva-Diz, Victoria, Muñoz, Purificación, Clevers, Hans, Sancho, Elena, Mangues, Ramón, Batlle, Eduard

“…A frequent complication in colorectal cancer (CRC) is regeneration of the tumor after therapy. Here, we report that a gene signature specific for adult…”
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Nodal-induced L1CAM/CXCR4 subpopulation sustains tumor growth and metastasis in colorectal cancer derived organoids by Cave, Donatella Delle, Hernando-Momblona, Xavier, Sevillano, Marta, Minchiotti, Gabriella, Lonardo, Enza

“…Colorectal cancer (CRC) is currently the third leading cause for cancer-related mortality. Cancer stem cells have been implicated in colorectal tumor growth,…”
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Mex3a marks drug-tolerant persister colorectal cancer cells that mediate relapse after chemotherapy by Álvarez-Varela, Adrián, Novellasdemunt, Laura, Barriga, Francisco M., Hernando-Momblona, Xavier, Cañellas-Socias, Adrià, Cano-Crespo, Sara, Sevillano, Marta, Cortina, Carme, Stork, Diana, Morral, Clara, Turon, Gemma, Slebe, Felipe, Jiménez-Gracia, Laura, Caratù, Ginevra, Jung, Peter, Stassi, Giorgio, Heyn, Holger, Tauriello, Daniele V. F., Mateo, Lidia, Tejpar, Sabine, Sancho, Elena, Stephan-Otto Attolini, Camille, Batlle, Eduard

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Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors by Herpers, Bram, Eppink, Berina, James, Mark I, Cortina, Carme, Cañellas-Socias, Adrià, Boj, Sylvia F, Hernando-Momblona, Xavier, Glodzik, Dominik, Roovers, Rob C, van de Wetering, Marc, Bartelink-Clements, Carina, Zondag-van der Zande, Vanessa, Mateos, Jara García, Yan, Kuan, Salinaro, Lucia, Basmeleh, Abdul, Fatrai, Szabolcs, Maussang, David, Lammerts van Bueren, Jeroen J, Chicote, Irene, Serna, Garazi, Cabellos, Laia, Ramírez, Lorena, Nuciforo, Paolo, Salazar, Ramon, Santos, Cristina, Villanueva, Alberto, Stephan-Otto Attolini, Camille, Sancho, Elena, Palmer, Hector G, Tabernero, Josep, Stratton, Michael R, de Kruif, John, Logtenberg, Ton, Clevers, Hans, Price, Leo S, Vries, Robert G J, Batlle, Eduard, Throsby, Mark

“…Patient-derived organoids (PDOs) recapitulate tumor architecture, contain cancer stem cells and have predictive value supporting personalized medicine. Here we…”
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New Potent Inhibitor of Transforming Growth Factor-Beta (TGFβ) Signaling that is Efficacious against Microsatellite Stable Colorectal Cancer Metastasis in Combination with Immune Checkpoint Therapy in Mice by Tauriello, Daniele V. F., Sancho, Elena, Byrom, Daniel, Sanchez-Zarzalejo, Carolina, Salvany, Maria, Henriques, Ana, Palomo-Ponce, Sergio, Sevillano, Marta, Hernando-Momblona, Xavier, Matarin, Joan A., Ramos, Israel, Ruano, Irene, Prats, Neus, Batlle, Eduard, Riera, Antoni

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Mex3a marks slow-proliferating multilineage progenitors of the intestinal epithelium by Barriga, Francisco M., Montagni, Elisa, Mana, Miyeko, Guillaumet-Adkins, Amy, Hernando-Momblona, Xavier, Sevillano, Marta, Rodriguez-Esteban, Gustavo, Mendez-Lago, Maria, Buczacki, Simon J. A., Gut, Ivo, Gut, Marta, Winton, Douglas J., Yilmaz, Omer, Stephan-Otto, Camille, Hein, Holger, Batlle, Eduard

“…The intestinal epithelium is continuously regenerated by highly proliferative Lgr5+ intestinal stem cells (ISCs). The existence of a population of quiescent…”
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TGF drives immune evasion in genetically reconstituted colon cancer metastasis by Tauriello, Daniele V. F, Palomo-Ponce, Sergio, Stork, Diana, Berenguer-Llergo, Antonio, Badia-Ramentol, Jordi, Iglesias, Mar, Sevillano, Marta, Ibiza, Sales, Caellas, Adri, Hernando-Momblona, Xavier, Byrom, Daniel, Matarin, Joan A, Calon, Alexandre, Rivas, Elisa I, Nebreda, Angel R, Riera, Antoni, Attolini, Camille Stephan-Otto, Batlle, Eduard

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Mex3a marks a slowly dividing subpopulation of Lgr5+ intestinal stem cells by Barriga de Vicente, Francisco Martín, 1983, Montagni, Elisa, 1984, Mana, Miyeko, Méndez Lago, María, Hernando-Momblona, Xavier, Sevillano, Marta, Guillaumet-Adkins, Amy, Rodríguez Esteban, Gustavo, Buczacki, Simon J.A, Gut, Marta, Heyn, Holger, Winton, Douglas J, Yilmaz, Omer H, Attolini, Camille Stephan-Otto, Gut, Ivo Glynne, Batlle Gómez, Eduard

“…Highly proliferative Lgr5+ stem cells maintain the intestinal epithelium and are thought to be largely homogeneous. Although quiescent intestinal stem cell…”
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