Search Results - "Hernandez, Matthew C."

YAP Tyrosine Phosphorylation and Nuclear Localization in Cholangiocarcinoma Cells Are Regulated by LCK and Independent of LATS Activity by Sugihara, Takaaki, Werneburg, Nathan W, Hernandez, Matthew C, Yang, Lin, Kabashima, Ayano, Hirsova, Petra, Yohanathan, Lavanya, Sosa, Carlos, Truty, Mark J, Vasmatzis, George, Gores, Gregory J, Smoot, Rory L

“…The Hippo pathway effector, Yes-associated protein (YAP), is a transcriptional coactivator implicated in cholangiocarcinoma (CCA) pathogenesis. YAP is known to…”
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Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas by Lenkiewicz, Elizabeth, Malasi, Smriti, Hogenson, Tara L, Flores, Luis F, Barham, Whitney, Phillips, William J, Roesler, Alexander S, Chambers, Kendall R, Rajbhandari, Nirakar, Hayashi, Akimasa, Antal, Corina E, Downes, Michael, Grandgenett, Paul M, Hollingsworth, Michael A, Cridebring, Derek, Xiong, Yuning, Lee, Jeong-Heon, Ye, Zhenqing, Yan, Huihuang, Hernandez, Matthew C, Leiting, Jennifer L, Evans, Ronald M, Ordog, Tamas, Truty, Mark J, Borad, Mitesh J, Reya, Tannishtha, Von Hoff, Daniel D, Fernandez-Zapico, Martin E, Barrett, Michael T

“…Adenosquamous cancer of the pancreas (ASCP) is a subtype of pancreatic cancer that has a worse prognosis and greater metastatic potential than the more common…”
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Platelet‐derived growth factor regulates YAP transcriptional activity via Src family kinase dependent tyrosine phosphorylation by Smoot, Rory L., Werneburg, Nathan W., Sugihara, Takaaki, Hernandez, Matthew C., Yang, Lin, Mehner, Christine, Graham, Rondell P., Bronk, Steven F., Truty, Mark J., Gores, Gregory J.

“…The Hippo pathway effector YAP is implicated in the pathogenesis of cholangiocarcinoma (CCA). The Hippo pathway relies on signaling cross talk for its…”
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Fibroblast growth factor receptor inhibition induces loss of matrix MCL1 and necrosis in cholangiocarcinoma by Kabashima, Ayano, Hirsova, Petra, Bronk, Steven F., Hernandez, Matthew C., Truty, Mark J., Ilyas, Sumera I., Kaufmann, Scott H., Gores, Gregory J.

“…[Display omitted] •Fibroblast growth factor receptor (FGFR) inhibitor, unexpectedly caused cell necrosis in human cholangiocarcinoma cells.•FGFR inhibition…”
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Adjuvant systemic therapy after resection of node positive gallbladder cancer: Time for a well-designed trial? (Results of a US-national retrospective cohort study) by Bergquist, John R., Shah, Harsh N., Habermann, Elizabeth B., Hernandez, Matthew C., Ivanics, Tommy, Kendrick, Michael L., Smoot, Rory L., Nagorney, David M., Borad, Mitesh J., McWilliams, Robert R., Truty, Mark J.

“…Ideal oncologic management of gallbladder carcinoma (GBCA) after complete surgical resection is unclear. We sought to define benefit of post-resection adjuvant…”
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Perioperative Use of Nonsteroidal Anti-Inflammatory Drugs and the Risk of Anastomotic Failure in Emergency General Surgery by Haddad, Nadeem N, Bruns, Brandon R, Enniss, Toby M, Turay, David, Sakran, Joseph V, Fathalizadeh, Alisan, Arnold, Kristen, Murry, Jason S, Carrick, Matthew M, Hernandez, Matthew, Lauerman, Margaret H, Zielinski, Martin D

“…Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used analgesic and anti-inflammatory adjuncts. NSAID administration may potentially increase the…”
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Successful Secondary Engraftment of Pancreatic Ductal Adenocarcinoma and Cholangiocarcinoma Patient-Derived Xenografts After Previous Failed Primary Engraftment by Hernandez, Matthew C., Yang, Lin, Leiting, Jennifer L., Sugihara, Takaaki, Bergquist, John R., Ivanics, Tommy, Graham, Rondell, Truty, Mark J.

“…BACKGROUND: Patient-derived xenografts (PDX) provide histologically accurate cancer models that recapitulate patient malignant phenotype and allow for highly…”
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Low anterior resection syndrome by Hernandez, Matthew C., Wong, Paul, Melstrom, Kurt

“…Low anterior resection syndrome represents a clinical state wherein a constellation of gastrointestinal symptoms is a direct result of anatomic changes to the…”
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Biliary tract cancer patient-derived xenografts: Surgeon impact on individualized medicine by Leiting, Jennifer L., Murphy, Stephen J., Bergquist, John R., Hernandez, Matthew C., Ivanics, Tommy, Abdelrahman, Amro M., Yang, Lin, Lynch, Isaac, Smadbeck, James B., Cleary, Sean P., Nagorney, David M., Torbenson, Michael S., Graham, Rondell P., Roberts, Lewis R., Gores, Gregory J., Smoot, Rory L., Truty, Mark J.

“…Biliary tract tumors are uncommon but highly aggressive malignancies with poor survival outcomes. Due to their low incidence, research into effective…”
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Injury Patterns and Outcomes of Ice-Fishing in the United States by Thiels, Cornelius A., DO, Hernandez, Matthew C., MD, Zielinski, Martin D., MD, Aho, Johnathon M., MD

“…Abstract Introduction Fishing is a common pastime. In the developed world, it is commonly performed as a recreational activity. We aim to determine injury…”
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CT-derived sarcopenia should not preclude surgical stabilization of traumatic rib fractures by Doolittle, Derrick A., Hernandez, Matthew C., Baffour, Francis I., Moynagh, Michael R., Takahashi, Naoki, Froemming, Adam T., Glazebrook, Katrina N., Kim, Brian D.

“…Background Rib fractures are associated with considerable morbidity and mortality. Surgical stabilization of rib fractures (SSRF) can be performed to mitigate…”
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Radiation Therapy for Retroperitoneal Sarcomas: Influences of Histology, Grade, and Size by Grotz, Travis E., Truty, Mark J., Robinson, Steven I., Folpe, Andrew L., Merrell, Kenneth W., Hernandez, Matthew C., Bergquist, John R., Leiting, Jennifer L., Nagorney, D. M.

“…Perioperative radiation therapy (RT) has been associated with reduced local recurrence in patients with retroperitoneal sarcomas (RPS); however, selection…”
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Complications in tube thoracostomy: Systematic review and meta-analysis by Hernandez, Matthew C, El Khatib, Moustafah, Prokop, Larry, Zielinski, Martin D, Aho, Johnathon M

“…Tube thoracostomy (TT) complications and their reported rates are highly variable (1-40%) and inconsistently classified. Consistent TT complication…”
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Ingested fishbone causing a hepatic abscess by Mirande, Maxwell D, Hernandez, Matthew C, Nagorney, David M

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Recurrence patterns after complex multimodality therapy and hepatic arterial infusion for colorectal liver metastases: A reflection of biology and technique by Hernandez, Matthew C., Fan, Darrell, Sandhu, Jaideep, Mahuron, Kelly, Kessler, Jonathan, Raoof, Mustafa, Fakih, Marwan, Singh, Gagandeep, Fong, Yuman, Melstrom, Laleh G.

“…Background and Methods We characterized colorectal liver metastasis recurrence and survival patterns after surgical resection and intraoperative ablation ±…”
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GI Surgical Emergencies: Scope and Burden of Disease by Hernandez, Matthew C., Madbak, Firas, Parikh, Katherine, Crandall, Marie

“…Nearly 3 million patients are hospitalized every year for emergent gastrointestinal (GI) surgical problems and nearly one third of those will require surgery…”
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Liver Resection With Extrahepatic Disease: A Population-Based Analysis of Thoughtful Selection by Mahuron, Kelly M, Hernandez, Matthew C, Wong, Paul, Fan, Darrell, Ituarte, Philip H G, Raoof, Mustafa, Singh, Gagandeep, Fong, Yuman, Melstrom, Laleh G

“…The oncologic benefit of liver resection for colorectal liver metastases (CRLM) in the setting of concurrent extrahepatic disease (EHD) is controversial. We…”
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Risk assessment in emergency general surgery by Hernandez, Matthew C, Havens, Joaquim M, Shafi, Shahid, Crandall, Marie

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Association of scooter-related injury and hospitalization with electronic scooter sharing systems in the United States by Traynor, Michael D., Lipsitz, Stuart, Schroeder, Thomas J., Zielinski, Martin D., Rivera, Mariela, Hernandez, Matthew C., Stephens, Daniel J.

“…We used interrupted time series (ITS) analysis to determine whether e-scooter shares' introduction in September 2017 increased serious scooter-related injury…”
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See one, do one, teach one - Trends in resident autonomy and teaching assistant cases during general surgery residency in the United States: A nationwide retrospective analysis by Sohail, Amir Humza, Nguyen, Hoang, Martinez, Kevin, Flesner, Samuel L., Martinez, Christian, Quazi, Mohammed A., Goyal, Aman, Sheikh, Abu Baker, Aziz, Hassan, Javed, Ammar Asrar, Whittington, Jennifer, Glynn, Loretto, Joseph, D'Andrea, Hernandez, Matthew C.

“…Autonomy during residency is crucial to the training and development of competent surgeons. An essential component of this process is the ‘teaching assistant…”
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